公开(公告)号：US07364904B2

公开(公告)日：2008-04-29

申请号：US10764328

申请日：2004-01-23

申请人： Charles D. Boyd ,  Katalin Csiszar ,  Olivier LeSaux ,  Zsolt Urban ,  Sharon Terry

发明人： Charles D. Boyd ,  Katalin Csiszar ,  Olivier LeSaux ,  Zsolt Urban ,  Sharon Terry

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： Methods and compositions are provided for diagnosing and treating Pseudoxanthoma elasticum (PXE) patients and PXE carriers. Methods and compositions are based on the discovery that PXE mutations are located in the MRP6 (ABCC6) gene.

摘要翻译： 提供了用于诊断和治疗Pseudoxanthoma弹性（PXE）患者和PXE载体的方法和组合物。 方法和组合是基于发现PXE突变位于MRP6（ABCC6）基因中的。

公开(公告)号：US06780587B2

公开(公告)日：2004-08-24

申请号：US09792616

申请日：2001-02-23

申请人： Charles D. Boyd ,  Katalin Csiszar ,  Olivier LeSaux ,  Zsolt Urban ,  Sharon Terry

发明人： Charles D. Boyd ,  Katalin Csiszar ,  Olivier LeSaux ,  Zsolt Urban ,  Sharon Terry

IPC分类号： C12Q168

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： Methods and compositions are provided for diagnosing and treating Pseudoxanthoma elasticum (PXE) patients and PXE carriers. Methods and compositions are based on the discovery that PXE mutations are located in the MRP6 (ABCC6) gene.

摘要翻译： 提供了用于诊断和治疗Pseudoxanthoma弹性（PXE）患者和PXE载体的方法和组合物。 方法和组合是基于发现PXE突变位于MRP6（ABCC6）基因中的。

公开(公告)号：US5340723A

公开(公告)日：1994-08-23

申请号：US869745

申请日：1992-04-16

申请人： Charles D. Boyd ,  Susan B. Deak

发明人： Charles D. Boyd ,  Susan B. Deak

IPC分类号： C12Q1/37 ,  G01N33/50 ,  C12Q1/02 ,  C12N5/00 ,  C12Q1/00 ,  G01N33/53

CPC分类号： G01N33/5091 ,  C12Q1/37 ,  G01N2333/78

摘要： The present invention pertains to a method for diagnosing for an aneurysm in a patient which comprises the steps of (a) explanting a skin section containing dermal fibroblast from the patient; (b) culturing the fibroblast to confluence in a culture medium; (c) incubating the cultured fibroblast with labeled proline to provide labeled procollagen in the culture medium; (d) separating the culture medium from the labeled procollagen and treating the labeled procollagen with a solution of protease inhibitor; (e) separating and purifying the labeled procollagen from the solution of protease inhibitor; (f) subjecting the labeled procollagen to protease digestion specific for non-collagenous proteins to form a collagenous mixture; (g) analyzing the collagenous mixture for the ratio of type I collagen to type III collagen; (h) analyzing a control collagenous mixture for the ratio of type I collagen to type III collagen; and (i) comparing the ratio of type I collagen to type III collagen in the collagenous mixture of step (g) to the control mixture of step (h), respectively.

摘要翻译： 本发明涉及一种用于诊断患者动脉瘤的方法，其包括以下步骤：（a）从患者体外移植含有真皮成纤维细胞的皮肤部分; （b）培养成纤维细胞以在培养基中汇合; （c）将培养的成纤维细胞与标记的脯氨酸孵育，以在培养基中提供标记的原胶原; （d）从标记的原胶原中分离培养基并用蛋白酶抑制剂的溶液处理标记的原胶原; （e）从蛋白酶抑制剂溶液中分离和纯化标记的原胶原; （f）对标记的原胶原蛋白进行非胶原蛋白特异性蛋白酶消化以形成胶原混合物; （g）分析胶原混合物中I型胶原与III型胶原的比例; （h）分析I型胶原与III型胶原的比例的对照胶原混合物; 和（i）分别将步骤（g）的胶原混合物中的I型胶原与III型胶原的比例分别与步骤（h）的对照混合物进行比较。

公开(公告)号：US08821291B2

公开(公告)日：2014-09-02

申请号：US13616669

申请日：2012-09-14

申请人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

发明人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

IPC分类号： A63F13/00 ,  G07F17/32

CPC分类号： G07F17/32 ,  G07F17/3276

摘要： The present invention embodiments pertain to conducting fantasy sports or other competitions, where users select or draft an entirely new team of professional players each week (or at other suitable time interval). The competition types (including playoffs) include fee based and free. Each fee based competition has a pre-determined entry fee, and prizes are awarded to the winner of that competition each week. The free competitions similarly include weekly prizes and further provide for a grand prize. Within each of the free and fee based types of competitions, users may compete in a “private” competition or a randomly composed “open” competition. Users within the free and fee based competitions may accumulate points that qualify for redemption to obtain prizes. These points are accumulated based upon the statistical performance of the drafted players for each team. The present invention embodiments further provide mechanisms for information sharing and interaction between users.

摘要翻译： 本发明实施例涉及进行幻想运动或其他比赛，其中用户每周（或以其他合适的时间间隔）选择或起草全新的专业球员队伍。 比赛类型（包括季后赛）包括收费和免费。 每个费用竞赛都有预先确定的入场费，奖品每周都会颁发给比赛的冠军。 免费比赛同样包括每周奖品，并进一步提供大奖。 在每个免费和费用类型的比赛中，用户可以参加“私人”比赛或随机组织的“开放”比赛。 免费和费用竞赛中的用户可能积累有资格获得奖品的积分。 这些积分是根据每个团队的起草人的统计表现积累的。 本发明实施例还提供了用户之间的信息共享和交互的机制。

公开(公告)号：US20130005422A1

公开(公告)日：2013-01-03

申请号：US13616669

申请日：2012-09-14

申请人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

发明人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

IPC分类号： A63F9/24

CPC分类号： G07F17/32 ,  G07F17/3276

摘要： The present invention embodiments pertain to conducting fantasy sports or other competitions, where users select or draft an entirely new team of professional players each week (or at other suitable time interval). The competition types (including playoffs) include fee based and free. Each fee based competition has a pre-determined entry fee, and prizes are awarded to the winner of that competition each week. The free competitions similarly include weekly prizes and further provide for a grand prize. Within each of the free and fee based types of competitions, users may compete in a “private” competition or a randomly composed “open” competition. Users within the free and fee based competitions may accumulate points that qualify for redemption to obtain prizes. These points are accumulated based upon the statistical performance of the drafted players for each team. The present invention embodiments further provide mechanisms for information sharing and interaction between users.

摘要翻译： 本发明实施例涉及进行幻想运动或其他比赛，其中用户每周（或以其他合适的时间间隔）选择或起草全新的专业球员队伍。 比赛类型（包括季后赛）包括收费和免费。 每个费用竞赛都有预先确定的入场费，奖品每周都会颁发给比赛的冠军。 免费比赛同样包括每周奖品，并进一步提供大奖。 在每个免费和费用类型的比赛中，用户可以竞争私人比赛或随机组织的公开竞争。 免费和费用竞赛中的用户可能积累有资格获得奖品的积分。 这些积分是根据每个团队的起草人的统计表现积累的。 本发明实施例还提供了用户之间的信息共享和交互的机制。

公开(公告)号：US08353772B2

公开(公告)日：2013-01-15

申请号：US12120491

申请日：2008-05-14

申请人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

发明人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

IPC分类号： A63F13/00

CPC分类号： G07F17/32 ,  G07F17/3276

摘要： The present invention embodiments pertain to conducting fantasy sports or other competitions, where users select or draft an entirely new team of professional players each week (or at other suitable time interval). The competition types (including playoffs) include fee based and free. Each fee based competition has a pre-determined entry fee, and prizes are awarded to the winner of that competition each week. The free competitions similarly include weekly prizes and further provide for a grand prize. Within each of the free and fee based types of competitions, users may compete in a “private” competition or a randomly composed “open” competition. Users within the free and fee based competitions may accumulate points that qualify for redemption to obtain prizes. These points are accumulated based upon the statistical performance of the drafted players for each team. The present invention embodiments further provide mechanisms for information sharing and interaction between users.

摘要翻译： 本发明实施例涉及进行幻想运动或其他比赛，其中用户每周（或以其他合适的时间间隔）选择或起草全新的专业球员队伍。 比赛类型（包括季后赛）包括收费和免费。 每个费用竞赛都有预先确定的入场费，奖品每周都会颁发给比赛的冠军。 免费比赛同样包括每周奖品，并进一步提供大奖。 在每个免费和费用类型的比赛中，用户可以竞争私人比赛或随机组织的公开竞争。 免费和费用竞赛中的用户可能积累有资格获得奖品的积分。 这些积分是根据每个团队的起草人的统计表现积累的。 本发明实施例还提供了用户之间的信息共享和交互的机制。

公开(公告)号：US20080287198A1

公开(公告)日：2008-11-20

申请号：US12120491

申请日：2008-05-14

申请人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

发明人： Brian Callery ,  Kevin M. Lanik ,  Charles D. Boyd

IPC分类号： A63F9/24

CPC分类号： G07F17/32 ,  G07F17/3276

摘要： The present invention embodiments pertain to conducting fantasy sports or other competitions, where users select or draft an entirely new team of professional players each week (or at other suitable time interval). The competition types (including playoffs) include fee based and free. Each fee based competition has a pre-determined entry fee, and prizes are awarded to the winner of that competition each week. The free competitions similarly include weekly prizes and further provide for a grand prize. Within each of the free and fee based types of competitions, users may compete in a “private” competition or a randomly composed “open” competition. Users within the free and fee based competitions may accumulate points that qualify for redemption to obtain prizes. These points are accumulated based upon the statistical performance of the drafted players for each team. The present invention embodiments further provide mechanisms for information sharing and interaction between users.

摘要翻译： 本发明实施例涉及进行幻想运动或其他比赛，其中用户每周（或以其他合适的时间间隔）选择或起草全新的专业球员队伍。 比赛类型（包括季后赛）包括收费和免费。 每个费用竞赛都有预先确定的入场费，奖品每周都会颁发给比赛的冠军。 免费比赛同样包括每周奖品，并进一步提供大奖。 在每个免费和费用类型的比赛中，用户可以参加“私人”比赛或随机组织的“开放”比赛。 免费和费用竞赛中的用户可能积累有资格获得奖品的积分。 这些积分是根据每个团队的起草人的统计表现积累的。 本发明实施例还提供了用户之间的信息共享和交互的机制。