公开(公告)号：US06413998B1

公开(公告)日：2002-07-02

申请号：US09453828

申请日：1999-12-02

申请人： Charles Petrie ,  Mark V. Craig ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Maria Kontoyianni ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark V. Craig ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Maria Kontoyianni ,  Gregory R. Mundy

IPC分类号： A61K3112

CPC分类号： A61K31/47 ,  A61K31/549 ,  A61K31/655

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

摘要翻译： 包含通过含有一个或多个原子的连接体共价连接的两个芳族体系的化合物或定义为包含共价键的“连接体”本身以便使芳族体系间距离为1.5-15，在治疗与 骨缺损。 化合物可以单独施用于脊椎动物，或者与促进骨生长或抑制骨吸收的其它试剂组合施用。 可以通过评估其在影响与骨形态发生蛋白相关的启动子相关的报告基因的转录和/或刺激模型动物系统中颅骨生长的能力的能力来筛选其给药前的活性。

公开(公告)号：US6008208A

公开(公告)日：1999-12-28

申请号：US878868

申请日：1997-06-19

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Maria Kontoyianni ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Maria Kontoyianni ,  Gregory R. Mundy

IPC分类号： A61K31/47 ,  A61K31/549 ,  A61K31/655 ,  A61K31/35 ,  A61K31/495

CPC分类号： A61K31/47 ,  A61K31/549 ,  A61K31/655

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US5919808A

公开(公告)日：1999-07-06

申请号：US808743

申请日：1997-02-28

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

IPC分类号： A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53 ,  A61K31/655 ,  A61K31/425 ,  A61K31/415 ,  A61K31/42

CPC分类号： A61K31/655 ,  A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15.ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US06342514B1

公开(公告)日：2002-01-29

申请号：US08808741

申请日：1997-02-28

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

IPC分类号： A61K31495

CPC分类号： A61K31/655 ,  A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US5965573A

公开(公告)日：1999-10-12

申请号：US812141

申请日：1997-03-06

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

IPC分类号： A61K31/196 ,  A61K31/428 ,  A61K31/444 ,  A61K31/655 ,  A61K31/33 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

CPC分类号： A61K31/444 ,  A61K31/196 ,  A61K31/428 ,  A61K31/655

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US5994358A

公开(公告)日：1999-11-30

申请号：US808744

申请日：1997-02-28

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Maria Kontoyianni ,  Gregory R. Mundy

IPC分类号： A61K31/47 ,  A61K31/498 ,  A61K31/655 ,  A61K31/495 ,  A61K31/35 ,  A61K31/38

CPC分类号： A61K31/655 ,  A61K31/47 ,  A61K31/498

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US5990169A

公开(公告)日：1999-11-23

申请号：US806771

申请日：1997-02-26

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Gregory R. Mundy

IPC分类号： A61K31/196 ,  A61K31/445 ,  A61K31/16 ,  A61K31/18

CPC分类号： A61K31/196

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US06649631B1

公开(公告)日：2003-11-18

申请号：US09297188

申请日：1999-11-19

申请人： Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Maria Kontoyianni ,  Laurence H. Hurley ,  Sean M. Kerwin ,  Gregory Mundy ,  Charles Petrie

发明人： Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Scott M. Harris ,  Maria Kontoyianni ,  Laurence H. Hurley ,  Sean M. Kerwin ,  Gregory Mundy ,  Charles Petrie

IPC分类号： A61K3144

CPC分类号： A61K31/44

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US6017940A

公开(公告)日：2000-01-25

申请号：US806770

申请日：1997-02-26

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Gregory R. Mundy

IPC分类号： A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53 ,  A61K31/655 ,  A61K31/425

CPC分类号： A61K31/655 ,  A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：US6153631A

公开(公告)日：2000-11-28

申请号：US806768

申请日：1997-02-26

申请人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Gregory R. Mundy

发明人： Charles Petrie ,  Mark W. Orme ,  Nand Baindur ,  Kirk G. Robbins ,  Gregory R. Mundy

IPC分类号： A61K31/428 ,  A61K31/425

CPC分类号： A61K31/428

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

摘要翻译： 包含通过含有一个或多个原子的接头共价连接的两个芳族体系的化合物或定义为包含共价键本身的“连接体”，以使芳族体系在距离为1.5-15安培的范围内空间有效地处理与 骨缺损。 化合物可以单独施用于脊椎动物，或者与促进骨生长或抑制骨吸收的其它试剂组合施用。 可以通过评估其在影响与骨形态发生蛋白相关的启动子相关的报告基因的转录和/或刺激模型动物系统中颅骨生长的能力的能力来筛选其给药前的活性。