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公开(公告)号:US20130313483A1
公开(公告)日:2013-11-28
申请号:US13817976
申请日:2011-08-22
申请人: Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
发明人: Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
IPC分类号: G01N33/18
CPC分类号: G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要: A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.
摘要翻译: 多相系统包括包含至少两相的相分离溶液,每相具有选自聚合物,表面活性剂及其组合的相组分,其中至少一相包含聚合物,其中相 一起表示密度梯度。 公开了新型的两相,三相,四相,五相或六相系统。 使用所公开的多相聚合物体系,可以基于它们不同的密度或亲和力来分离颗粒或感兴趣的其它分析物。
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公开(公告)号:US09714934B2
公开(公告)日:2017-07-25
申请号:US13817976
申请日:2011-08-22
申请人: Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
发明人: Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
IPC分类号: G01N33/00 , G01N33/49 , B03B5/28 , B03B5/44 , B03D3/00 , G01N33/537 , G01N33/574 , G01N33/18
CPC分类号: G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要: A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.
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3.
公开(公告)号:US09176105B2
公开(公告)日:2015-11-03
申请号:US13817985
申请日:2011-08-22
IPC分类号: A01N1/02 , G01N33/18 , B03B5/28 , B03B5/44 , B03D3/00 , G01N33/49 , G01N33/537 , G01N33/574
CPC分类号: G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要: The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.
摘要翻译: 所公开的方法使用多相系统根据感兴趣的分析物的密度分离样品。 该方法使用包含两个或多个相分离溶液和相成分如表面活性剂或聚合物的多相体系。 感兴趣的分析物的密度与样品其余部分的密度不同。 感兴趣的分析物的密度基本上与一个或多个相位相同。 因此,当将样品引入多相系统时,感兴趣的分析物迁移到具有与感兴趣的分析物相同的密度的相位,顺序地通过一个或多个相。
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公开(公告)号:US20130280693A1
公开(公告)日:2013-10-24
申请号:US13817985
申请日:2011-08-22
IPC分类号: G01N33/49 , G01N33/574
CPC分类号: G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要: The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.
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