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公开(公告)号：US09714934B2
公开(公告)日：2017-07-25
申请号：US13817976
申请日：2011-08-22
申请人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
发明人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
IPC分类号： G01N33/00 , G01N33/49 , B03B5/28 , B03B5/44 , B03D3/00 , G01N33/537 , G01N33/574 , G01N33/18
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.
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公开(公告)号：US20130313483A1
公开(公告)日：2013-11-28
申请号：US13817976
申请日：2011-08-22
申请人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
发明人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
IPC分类号： G01N33/18
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.
摘要翻译： 多相系统包括包含至少两相的相分离溶液，每相具有选自聚合物，表面活性剂及其组合的相组分，其中至少一相包含聚合物，其中相 一起表示密度梯度。 公开了新型的两相，三相，四相，五相或六相系统。 使用所公开的多相聚合物体系，可以基于它们不同的密度或亲和力来分离颗粒或感兴趣的其它分析物。
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公开(公告)号：US20130280693A1
公开(公告)日：2013-10-24
申请号：US13817985
申请日：2011-08-22
IPC分类号： G01N33/49 , G01N33/574
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.
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4.发明授权公开(公告)号：US09176105B2
公开(公告)日：2015-11-03
申请号：US13817985
申请日：2011-08-22
IPC分类号： A01N1/02 , G01N33/18 , B03B5/28 , B03B5/44 , B03D3/00 , G01N33/49 , G01N33/537 , G01N33/574
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.
摘要翻译： 所公开的方法使用多相系统根据感兴趣的分析物的密度分离样品。 该方法使用包含两个或多个相分离溶液和相成分如表面活性剂或聚合物的多相体系。 感兴趣的分析物的密度与样品其余部分的密度不同。 感兴趣的分析物的密度基本上与一个或多个相位相同。 因此，当将样品引入多相系统时，感兴趣的分析物迁移到具有与感兴趣的分析物相同的密度的相位，顺序地通过一个或多个相。
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公开(公告)号：US20130316387A1
公开(公告)日：2013-11-28
申请号：US13808887
申请日：2011-07-12
申请人： Charles R. Mace , Jabulani Barber , Anna Laromaine Sagué , George M. Whitesides , Rebecca Cademartiri
发明人： Charles R. Mace , Jabulani Barber , Anna Laromaine Sagué , George M. Whitesides , Rebecca Cademartiri
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , C12N5/0068 , C12N2533/30 , C12N2533/56 , C12N2533/74 , D01D5/40 , D01F9/04
摘要： Alginate hydrogel fibers and related materials as well as methods for preparing such materials are provided. An alginate hydrogel fiber includes water in an amount of more than about 92% by weight of the fiber and a cross-linked alginate in an amount of about 0.1% to about 8% by weight of the fiber, wherein the cross-link is a cation. An alginate hydrogel paper includes one or more alginate hydrogel fibers, which form a non-woven matrix. Three-dimensional cellular arrays are also provided, wherein the alginate hydrogel making up the alginate paper is substantially index-matched with a predetermined culture medium. A method for making alginate hydrogel fiber and a method for index-matching alginate hydrogel paper with culture medium are provided. A kit for conducting biochemical, diagnostic, cellular, and/or non-cellular analysis comprises alginate hydrogel paper index-matched to culture medium.
摘要翻译： 提供藻酸盐水凝胶纤维及相关材料以及制备这些材料的方法。 藻酸盐水凝胶纤维包含水量大于纤维重量的约92％，交联藻酸盐的量为纤维重量的约0.1％至约8％，其中交联是 阳离子。 藻酸盐水凝胶纸包括形成非织造基质的一种或多种藻酸盐水凝胶纤维。 还提供三维细胞阵列，其中构成藻酸盐纸的藻酸盐水凝胶与预定培养基基本上是指数匹配的。 提供了藻酸盐水凝胶纤维的制备方法和藻酸盐水凝胶纸与培养基的折射率匹配方法。 用于进行生化，诊断，细胞和/或非细胞分析的试剂盒包括与培养基指数匹配的藻酸盐水凝胶纸。
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公开(公告)号：US20130133419A1
公开(公告)日：2013-05-30
申请号：US13594518
申请日：2012-08-24
申请人： George M. Whitesides , Matthew R. Lockett , Katherine A. Mirica , Charles R. Mace , Robert D. Blackledge
发明人： George M. Whitesides , Matthew R. Lockett , Katherine A. Mirica , Charles R. Mace , Robert D. Blackledge
IPC分类号： G01N9/00
摘要： A method for determining the density of contact trace objects with magnetic levitation is described. The density of samples of glitter and of gunpowder was determined, and the feasibility of magnetic levitation as a possible means of characterizing forensic-related evidence is discussed. The magnetic levitation device (composed of two permanent magnets with like poles facing) and the method described provides a means of accurately determining the density of trace objects that is inexpensive, rapid, verifiable, provides documentation, is independent of the specific apparatus or analyst, and provides numerical values (rather than a comparison between questioned and known samples) that may be entered into a searchable database.
摘要翻译： 描述了一种用磁悬浮确定接触痕迹物体的密度的方法。 确定了闪光和火药样品的密度，讨论了磁悬浮作为鉴定法证相关证据的可能手段的可行性。 磁悬浮装置（由具有相同磁极的两个永磁体组成）和所述方法提供了一种准确地确定跟踪物体的密度的方法，该物体廉价，快速，可验证，提供文件，独立于具体装置或分析者， 并提供可输入到可搜索数据库中的数值（而不是有疑问和已知样本之间的比较）。
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7.发明申请公开(公告)号：US20120302456A1
公开(公告)日：2012-11-29
申请号：US13303797
申请日：2011-11-23
CPC分类号： G01N33/54306 , G01N33/54366 , Y02A50/58
摘要： The invention provides kits, methods and devices for detection of analytes in a biological sample. Capillary action is employed to carry out single or multiplexed immunoassays in a vertical flow-through format.
摘要翻译： 本发明提供用于检测生物样品中分析物的试剂盒，方法和装置。 毛细管作用用于以垂直流通形式进行单次或多路复用的免疫测定。
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公开(公告)号：US09090868B2
公开(公告)日：2015-07-28
申请号：US13808887
申请日：2011-07-12
申请人： Charles R. Mace , Jabulani Barber , Anna Laromaine Sagué , George M. Whitesides , Rebecca Cademartiri
发明人： Charles R. Mace , Jabulani Barber , Anna Laromaine Sagué , George M. Whitesides , Rebecca Cademartiri
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , C12N5/0068 , C12N2533/30 , C12N2533/56 , C12N2533/74 , D01D5/40 , D01F9/04
摘要： Alginate hydrogel fibers and related materials as well as methods for preparing such materials are provided. An alginate hydrogel fiber includes water in an amount of more than about 92% by weight of the fiber and a cross-linked alginate in an amount of about 0.1% to about 8% by weight of the fiber, wherein the cross-link is a cation. An alginate hydrogel paper includes one or more alginate hydrogel fibers, which form a non-woven matrix. Three-dimensional cellular arrays are also provided, wherein the alginate hydrogel making up the alginate paper is substantially index-matched with a predetermined culture medium. A method for making alginate hydrogel fiber and a method for index-matching alginate hydrogel paper with culture medium are provided. A kit for conducting biochemical, diagnostic, cellular, and/or non-cellular analysis comprises alginate hydrogel paper index-matched to culture medium.
摘要翻译： 提供藻酸盐水凝胶纤维及相关材料以及制备这些材料的方法。 藻酸盐水凝胶纤维包含水量大于纤维重量的约92％，交联藻酸盐的量为纤维重量的约0.1％至约8％，其中交联是 阳离子。 藻酸盐水凝胶纸包括形成非织造基质的一种或多种藻酸盐水凝胶纤维。 还提供三维细胞阵列，其中构成藻酸盐纸的藻酸盐水凝胶与预定培养基基本上是指数匹配的。 提供了藻酸盐水凝胶纤维的制备方法和藻酸盐水凝胶纸与培养基的折射率匹配方法。 用于进行生化，诊断，细胞和/或非细胞分析的试剂盒包括与培养基指数匹配的藻酸盐水凝胶纸。
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公开(公告)号：US20140220500A1
公开(公告)日：2014-08-07
申请号：US14119560
申请日：2012-05-31
申请人： Ludovico Cademartiri , Charles R. Mace , Robert Shepherd , Aaron D. Mazzeo , Kyle J.M. Bishop , Ryan C. Chiechi , George M. Whitesides
发明人： Ludovico Cademartiri , Charles R. Mace , Robert Shepherd , Aaron D. Mazzeo , Kyle J.M. Bishop , Ryan C. Chiechi , George M. Whitesides
IPC分类号： F23N5/00
CPC分类号： F23N5/00 , F23C99/001
摘要： Manipulation of flames is described using electric fields. In those instances in which electric fields are used, the electric fields may be time-varying gradient electric fields, and in some instances may be oscillating electric fields. The manipulation may include extinction, suppression, control of mixing of the flame, concentration, and/or bending, among other types.
摘要翻译： 使用电场描述火焰的操纵。 在使用电场的情况下，电场可以是时变梯度电场，并且在一些情况下可以是振荡电场。 操作可以包括消除，抑制，火焰混合的控制，浓度和/或弯曲等。
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公开(公告)号：US20090275016A1
公开(公告)日：2009-11-05
申请号：US12434438
申请日：2009-05-01
CPC分类号： G01N33/56983 , C12N2760/16011 , G01N21/05 , G01N21/211 , G01N21/553 , G01N33/54373 , G01N2021/1725 , G01N2021/558 , G01N2021/5957 , G01N2333/11 , G01N2800/52
摘要： A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.
摘要翻译： 一种用于检测针对流感病毒的免疫应答的传感器芯片，所述传感器芯片包括具有表面的底物和与所述底物表面上的离散位置结合的多个血凝素多肽，每个血凝素多肽具有血凝素表位。 本文还描述了包含传感器芯片的检测装置和检测流感免疫应答的方法。
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