公开(公告)号：US08394463B1

公开(公告)日：2013-03-12

申请号：US12692001

申请日：2010-01-22

申请人： Chia-Hung Chiu ,  Marco Sillus ,  Barry Pham ,  Ly Phou ,  Gil Bruso ,  Christopher R. Enegren ,  Heath Jensen ,  Michael Paul Minor ,  Rajiv Shah

发明人： Chia-Hung Chiu ,  Marco Sillus ,  Barry Pham ,  Ly Phou ,  Gil Bruso ,  Christopher R. Enegren ,  Heath Jensen ,  Michael Paul Minor ,  Rajiv Shah

IPC分类号： C08J7/16

CPC分类号： G01N27/3272 ,  C08J3/246

摘要： Embodiments of the invention provide methods of crosslinking various compounds and materials made by these methods. Materials made by embodiments of the invention include glucose sensors used in the management of diabetes.

摘要翻译： 本发明的实施方案提供了交联通过这些方法制备的各种化合物和材料的方法。 由本发明的实施方案制备的材料包括用于治疗糖尿病的葡萄糖传感器。

公开(公告)号：US20080027287A1

公开(公告)日：2008-01-31

申请号：US11493054

申请日：2006-07-26

申请人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

发明人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

IPC分类号： A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6849

摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括靠近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。

公开(公告)号：US09492111B2

公开(公告)日：2016-11-15

申请号：US11493054

申请日：2006-07-26

申请人： Rajiv Shah ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

发明人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

IPC分类号： A61B5/00 ,  A61B5/1486 ,  A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6849

摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括邻近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。