公开(公告)号：US20080027287A1

公开(公告)日：2008-01-31

申请号：US11493054

申请日：2006-07-26

申请人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

发明人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

IPC分类号： A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6849

摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括靠近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。

公开(公告)号：US09492111B2

公开(公告)日：2016-11-15

申请号：US11493054

申请日：2006-07-26

申请人： Rajiv Shah ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

发明人： Rajiv Shah ,  Udo Hoss ,  Gopikrishnan Soundararajan ,  Nannette M. Van Antwerp ,  Barry Pham

IPC分类号： A61B5/00 ,  A61B5/1486 ,  A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6849

摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.

摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括邻近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。

公开(公告)号：US07468033B2

公开(公告)日：2008-12-23

申请号：US10935954

申请日：2004-09-08

申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

IPC分类号： A61B5/00 ,  A61M37/00

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

公开(公告)号：US20090149728A1

公开(公告)日：2009-06-11

申请号：US12264810

申请日：2008-11-04

申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

IPC分类号： A61B5/1468

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

公开(公告)号：US08352011B2

公开(公告)日：2013-01-08

申请号：US12264810

申请日：2008-11-04

申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Larry Wang ,  Kent L. Clark

发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Larry Wang ,  Kent L. Clark

IPC分类号： A61B5/05

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

公开(公告)号：US20120004524A1

公开(公告)日：2012-01-05

申请号：US13233338

申请日：2011-09-15

申请人： Nannette M. Van Antwerp ,  Udo Hoss

发明人： Nannette M. Van Antwerp ,  Udo Hoss

IPC分类号： A61B5/145

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.

摘要翻译： 用于检测血液中分析物的方法和装置可用于检测受试者组织中的分析物。 该装置包括传感器，其包括具有突出端的细长导电材料，该突出端包括检测分析物的存在的电极; 固定在导电材料上的基板; 以及具有外表面，近端和远端的支撑件。 导电材料定位在支撑件上，并且导电材料的突出端突出超出支撑件的远端。 可选地，传感器悬挂在静脉流动装置的内腔内。 通常，只有一部分传感器悬挂在静脉流装置的内腔内，所述部分包括导电材料的突出端。 或者，导电材料定位在静脉输液导管的外表面上。

公开(公告)号：US08032198B2

公开(公告)日：2011-10-04

申请号：US11348894

申请日：2006-02-07

申请人： Nannette M. Van Antwerp ,  Udo Hoss

发明人： Nannette M. Van Antwerp ,  Udo Hoss

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.

摘要翻译： 用于检测血液中分析物的方法和装置可用于检测受试者组织中的分析物。 该装置包括传感器，其包括具有突出端的细长导电材料，该突出端包括检测分析物的存在的电极; 固定在导电材料上的基板; 以及具有外表面，近端和远端的支撑件。 导电材料定位在支撑件上，并且导电材料的突出端突出超出支撑件的远端。 可选地，传感器悬挂在静脉流动装置的内腔内。 通常，只有一部分传感器悬挂在静脉流装置的内腔内，所述部分包括导电材料的突出端。 或者，导电材料定位在静脉输液导管的外表面上。

公开(公告)号：US08600470B2

公开(公告)日：2013-12-03

申请号：US13233338

申请日：2011-09-15

申请人： Nannette M. Van Antwerp ,  Udo Hoss

发明人： Nannette M. Van Antwerp ,  Udo Hoss

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.

摘要翻译： 用于检测血液中分析物的方法和装置可用于检测受试者组织中的分析物。 该装置包括传感器，其包括具有突出端的细长导电材料，该突出端包括检测分析物的存在的电极; 固定在导电材料上的基板; 以及具有外表面，近端和远端的支撑件。 导电材料定位在支撑件上，并且导电材料的突出端突出超出支撑件的远端。 可选地，传感器悬挂在静脉流动装置的内腔内。 通常，只有一部分传感器悬挂在静脉流装置的内腔内，所述部分包括导电材料的突出端。 或者，导电材料定位在静脉输液导管的外表面上。

公开(公告)号：US20090062767A1

公开(公告)日：2009-03-05

申请号：US11897106

申请日：2007-08-29

申请人： Nannette M. Van Antwerp ,  Rajiv Shah ,  Bradley J. Enegren ,  Richard Lemos, JR. ,  Ly Phou ,  Garry M. Steil ,  Gayane R. Voskanyan

发明人： Nannette M. Van Antwerp ,  Rajiv Shah ,  Bradley J. Enegren ,  Richard Lemos, JR. ,  Ly Phou ,  Garry M. Steil ,  Gayane R. Voskanyan

IPC分类号： A61M5/142 ,  A61M25/02

CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/4839 ,  A61B5/6846 ,  A61B5/6848 ,  A61B5/6849 ,  A61M5/14248 ,  A61M5/158 ,  A61M5/172 ,  A61M2005/14252 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2005/1587 ,  A61M2005/1726 ,  A61M2230/201

摘要： Embodiments of the invention provide a dual insertion set for supplying a fluid to the body of a patient and for monitoring a body characteristic of the patient. Typical embodiments of the invention include a base, an infusion portion coupled to a first piercing member and a sensor portion coupled to a second piercing member. The infusion portion includes a cannula coupled to the piercing member for supplying a fluid to a placement site. The sensor portion includes a sensor coupled to and extending from the base having at least one sensor electrode formed on a substrate and is coupled to the piercing member in a manner that allows the sensor to be inserted at the placement site. The base is arranged to secure the dual insertion set to the skin of a patient. Typically the infusion portion and sensor portion piercing members are arranged such that when they are operatively coupled to the base, they are disposed in a spatial orientation designed to inhibit sensor interference that may be caused by compounds present in fluids infused through the cannula.

摘要翻译： 本发明的实施例提供了一种用于向患者的身体供应流体并用于监测患者的身体特征的双重插入组。 本发明的典型实施例包括底座，联接到第一刺穿构件的输注部分和联接到第二穿刺构件的传感器部分。 输注部分包括联接到穿刺构件的套管，用于将流体供应到放置位置。 所述传感器部分包括传感器，所述传感器耦合到所述底座并且具有至少一个传感器电极并从所述底座延伸并且以允许所述传感器插入所述放置位置的方式联接到所述穿孔构件。 基座设置成将双重插入件固定到患者的皮肤上。 通常，输注部分和传感器部分刺穿构件被布置成使得当它们可操作地联接到基部时，它们被设置成空间方向，其设计成阻止可能由存在于通过插管注入的流体中的化合物引起的传感器干扰。

公开(公告)号：US09968742B2

公开(公告)日：2018-05-15

申请号：US11897106

申请日：2007-08-29

申请人： Nannette M. Van Antwerp ,  Rajiv Shah ,  Bradley J. Enegren ,  Richard Lemos, Jr. ,  Ly Phou ,  Garry M. Steil ,  Gayane R. Voskanyan

发明人： Nannette M. Van Antwerp ,  Rajiv Shah ,  Bradley J. Enegren ,  Richard Lemos, Jr. ,  Ly Phou ,  Garry M. Steil ,  Gayane R. Voskanyan

IPC分类号： A61M5/172 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/158 ,  A61B5/1486

CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/4839 ,  A61B5/6846 ,  A61B5/6848 ,  A61B5/6849 ,  A61M5/14248 ,  A61M5/158 ,  A61M5/172 ,  A61M2005/14252 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2005/1587 ,  A61M2005/1726 ,  A61M2230/201

摘要： Embodiments of the invention provide a dual insertion set for supplying a fluid to a body of a patient and for monitoring a body characteristic of the patient. Typical embodiments of the invention include a base, an infusion portion coupled to a first piercing member and a sensor portion coupled to a second piercing member. The infusion portion includes a cannula coupled to the first piercing member for supplying the fluid to a placement site. The sensor portion includes a sensor coupled to and extending from the base having at least one sensor electrode formed on a substrate and is coupled to the second piercing member in a manner that allows the sensor to be inserted at the placement site. The base is arranged to secure the dual insertion set to skin of the patient. Typically the first and second piercing members are arranged such that when the first and second piercing members are operatively coupled to the base, they are disposed in a spatial orientation designed to inhibit sensor interference that may be caused by compounds present in fluids infused through the cannula.