公开(公告)号：US20240132923A1

公开(公告)日：2024-04-25

申请号：US18188995

申请日：2023-03-22

申请人： China Petrochemical Development Corporation, Taipei (Taiwan) ,  NATIONAL CHEN KUNG UNIVERSITY

发明人： I-Son NG ,  Jo-Shu CHANG ,  Chuan-Chieh HSIANG ,  Yeong-Chang CHEN ,  Yu-Chiao LIU ,  Chia-Wei TSAI

IPC分类号： C12P7/46 ,  C12N9/88 ,  C12N15/52 ,  C12N15/70

CPC分类号： C12P7/46 ,  C12N9/88 ,  C12N15/52 ,  C12N15/70 ,  C12R2001/19 ,  C12Y401/01006 ,  C12Y402/01003

摘要： Provided is a recombinant microorganism including at least two genes for producing itaconic acid and its derived monomers, and the at least two genes are located on the same expression vector. The at least two genes include one encoding cis-aconitic acid decarboxylase and the other one encoding aconitase, and the genome of the recombinant microorganism includes a gene encoding the molecular chaperone protein GroELS. Also provided is a method for producing itaconic acid by using the microorganism.

公开(公告)号：US20240240210A9

公开(公告)日：2024-07-18

申请号：US18188995

申请日：2023-03-23

申请人： China Petrochemical Development Corporation, Taipei (Taiwan) ,  NATIONAL CHEN KUNG UNIVERSITY

发明人： I-Son NG ,  Jo-Shu CHANG ,  Chuan-Chieh HSIANG ,  Yeong-Chang CHEN ,  Yu-Chiao LIU ,  Chia-Wei TSAI

IPC分类号： C12P7/46 ,  C12N9/88 ,  C12N15/52 ,  C12N15/70

CPC分类号： C12P7/46 ,  C12N9/88 ,  C12N15/52 ,  C12N15/70 ,  C12R2001/19 ,  C12Y401/01006 ,  C12Y402/01003

摘要： Provided is a recombinant microorganism including at least two genes for producing itaconic acid and its derived monomers, and the at least two genes are located on the same expression vector. The at least two genes include one encoding cis-aconitic acid decarboxylase and the other one encoding aconitase, and the genome of the recombinant microorganism includes a gene encoding the molecular chaperone protein GroELS. Also provided is a method for producing itaconic acid by using the microorganism.

公开(公告)号：US20220380745A1

公开(公告)日：2022-12-01

申请号：US17333141

申请日：2021-05-28

申请人： CHINA PETROCHEMICAL DEVELOPMENT CORPORATION, TAIPEI (TAIWAN)

发明人： Jo-Shu CHANG ,  I-Son NG ,  Cheng-Feng XUE ,  Ying-Jung CHEN ,  Chang-Yi CHEN ,  Yu-Chiao LIU

IPC分类号： C12N9/88 ,  C12N9/12 ,  C12P13/00

摘要： Provided is a non-naturally occurring microorganism capable of producing cadaverine, wherein the microorganism is genetically modified to overexpress lysine decarboxylase and pyridoxal kinase. Also provided is a method for producing cadaverine by using such microorganism without adding external pyridoxal 5′-phosphate.