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公开(公告)号:US20060264461A1
公开(公告)日:2006-11-23
申请号:US11494917
申请日:2006-07-28
申请人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
发明人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
IPC分类号: A61K31/4709 , A61K31/4439 , A61K31/427 , A61K31/4178 , A61K31/4172 , C07D403/02 , C07D417/02
CPC分类号: C07D233/88 , C07D409/04 , C07D417/04 , C07D417/14
摘要: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
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公开(公告)号:US06903104B2
公开(公告)日:2005-06-07
申请号:US10310711
申请日:2002-12-05
申请人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
发明人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
IPC分类号: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/405 , C07D407/12 , C07D413/12
CPC分类号: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要: The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula. In this formula, each R1 is independently isoxazolyl, thiazolyl, isothiazolyl, 1,3,4-thiadiazolyl, 1,3-benzothiazolyl, quinolyl, isoquinolyl, thionaphthenyl, or benzofuranyl, each being optionally substituted with 1-6 independent R5; or when taken together with R2 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R2 is independently H, C1-C10 alkyl, or aryl, each being optionally substituted with 1-4 independent R5; or when taken together with R1 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R3 is independently C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, pyridyl, or heterocyclyl, each being optionally substituted with 1-4 independent R5. Each R4 is independently H, NO2, halo, CN, R7, OR7, CO2R7, SR7, NR7R7, C(O)R7, C(O)NR7R7, OC(O)R7, S(O)2R7, S(O)2NR7R7, NR7C(O)NR7R7, NR7C(O)R7, NR7(COOR7), NR7S(O)2NR7R7, NR7S(O)2R7, or S(O)2OR7.
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公开(公告)号:US07662834B2
公开(公告)日:2010-02-16
申请号:US12132254
申请日:2008-06-03
申请人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
发明人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
IPC分类号: A01N43/42 , A61K31/47 , A61K31/44 , A61K31/425 , A01N43/80
CPC分类号: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要: This invention relates to treating cancer or an angiogenesis-related disease using a compound of formula 1: wherein R1, R2, R3, R4, and n are defined herein.
摘要翻译: 本发明涉及使用式1化合物治疗癌症或血管发生相关疾病:其中R1,R2,R3,R4和n如本文所定义。
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公开(公告)号:US20060264462A1
公开(公告)日:2006-11-23
申请号:US11495044
申请日:2006-07-28
申请人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
发明人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
IPC分类号: A61K31/4709 , A61K31/4439 , A61K31/4178 , A61K31/4172 , A61K31/427 , C07D417/02 , C07D403/02
CPC分类号: C07D233/88 , C07D409/04 , C07D417/04 , C07D417/14
摘要: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
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公开(公告)号:US07109227B2
公开(公告)日:2006-09-19
申请号:US10649233
申请日:2003-08-26
申请人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
发明人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
IPC分类号: A61K31/4168 , C07D233/88
CPC分类号: C07D233/88 , C07D409/04 , C07D417/04 , C07D417/14
摘要: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
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公开(公告)号:US07462723B2
公开(公告)日:2008-12-09
申请号:US11472064
申请日:2006-06-21
申请人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
发明人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
IPC分类号: A61K31/427 , C07D417/04
CPC分类号: C07D233/88 , C07D409/04 , C07D417/04 , C07D417/14
摘要: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
摘要翻译: 本发明涉及新的咪唑氨基化合物。 还公开了通过使用这些化合物之一和含有这些化合物之一的药物组合物来治疗癌症的方法。
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公开(公告)号:US20050234098A1
公开(公告)日:2005-10-20
申请号:US11145628
申请日:2005-06-06
申请人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
发明人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
IPC分类号: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/4709 , A61K31/405 , A61K31/422 , A61K31/427 , A61K31/433 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要: This invention relates to novel heteroatom containing compounds and compositions thereof, and their use for the prevention and treatment of disease. The invention also provides for methods of making the compounds. The invention is based on the discovery that certain heteroatom containing compounds, 3-oxoacetamideindolyl compounds, have potent anticancer, cytotoxic, and anti-angiogenic activity.
摘要翻译: 本发明涉及含杂原子的化合物及其组合物及其用于预防和治疗疾病的用途。 本发明还提供了制备化合物的方法。 本发明基于以下发现:某些含杂原子的化合物3-氧代乙酰胺吲哚基化合物具有有效的抗癌,细胞毒性和抗血管生成活性。
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公开(公告)号:US07569596B2
公开(公告)日:2009-08-04
申请号:US11494917
申请日:2006-07-28
申请人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
发明人: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
IPC分类号: A61K31/4168
CPC分类号: C07D233/88 , C07D409/04 , C07D417/04 , C07D417/14
摘要: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
摘要翻译: 本发明涉及新的咪唑氨基化合物。 还公开了通过使用这些化合物之一和含有这些化合物之一的药物组合物来治疗癌症的方法。
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公开(公告)号:US07396838B2
公开(公告)日:2008-07-08
申请号:US11145628
申请日:2005-06-06
申请人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
发明人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
IPC分类号: A01N43/42 , A01N43/82 , A01N43/78 , A01N43/80 , A01N43/64 , A01N43/38 , A61K31/47 , A61K31/41 , A61K31/425 , A61K31/42 , A61K31/40 , C07D217/00 , C07D215/38 , C07D417/00 , C07D263/00 , C07D413/00 , C07D261/04 , C07D261/14 , C07D405/00 , C07D409/00 , C07D411/00
CPC分类号: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要: A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein R1, R2, R3, R4, and n are as defined herein.
摘要翻译: 一种治疗癌症的方法,包括向有需要的受试者施用有效量的式1化合物:其中R 1,R 2,R 3, R 4,R 4和n如本文所定义。
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公开(公告)号:US20080242701A1
公开(公告)日:2008-10-02
申请号:US12132254
申请日:2008-06-03
申请人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
发明人: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
IPC分类号: A61K31/4709 , A61K31/4439 , A61K31/427 , A61P17/06
CPC分类号: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要: This invention relates to treating cancer or an angiogenesis-related disease using a compound of formula 1: wherein R1, R2, R3, R4, and n are defined herein.
摘要翻译: 本发明涉及使用式1化合物治疗癌症或血管发生相关疾病:其中R 1,R 2,R 3, R 4,和n在本文中定义。
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