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公开(公告)号：US08389560B2
公开(公告)日：2013-03-05
申请号：US12559818
申请日：2009-09-15
Applicant: Chen-Fu Liu , Kuang-Yuan Lee , Pei-Chin Cheng , Yo-Chin Liu , Pin Lo , Kuo-Feng Tseng , Chih-Ming Chen , Chi-Hsin Richard King , Chu-Chung Lin
Inventor： Chen-Fu Liu , Kuang-Yuan Lee , Pei-Chin Cheng , Yo-Chin Liu , Pin Lo , Kuo-Feng Tseng , Chih-Ming Chen , Chi-Hsin Richard King , Chu-Chung Lin
IPC: A61K31/407 , C07D245/04 , C07D401/12
CPC classification number: C07K5/0804 , A61K31/4355 , A61K31/519 , A61K38/00 , C07D491/048 , C07D519/00
Abstract: This invention relates to macrocyclic compounds of formula (I) shown in the specification. These compounds can be used to treat hepatitis C virus infection.
Abstract translation: 本发明涉及说明书中所示的式（I）的大环化合物。 这些化合物可用于治疗丙型肝炎病毒感染。
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公开(公告)号：US20110065737A1
公开(公告)日：2011-03-17
申请号：US12559818
申请日：2009-09-15
Applicant: Chen-Fu Liu , Kuang-Yuan Lee , Pei-Chin Cheng , Yo-Chin Liu , Pin Lo , Kuo-Feng Tseng , Chih-Ming Chen , Chi-Hsin Richard King , Chu-Chung Lin
Inventor： Chen-Fu Liu , Kuang-Yuan Lee , Pei-Chin Cheng , Yo-Chin Liu , Pin Lo , Kuo-Feng Tseng , Chih-Ming Chen , Chi-Hsin Richard King , Chu-Chung Lin
IPC: A61K31/519 , A61K31/4355 , A61P31/12 , C07D245/00
CPC classification number: C07K5/0804 , A61K31/4355 , A61K31/519 , A61K38/00 , C07D491/048 , C07D519/00
Abstract: This invention relates to macrocyclic compounds of formula (I) shown in the specification. These compounds can be used to treat hepatitis C virus infection.
Abstract translation: 本发明涉及说明书中所示的式（I）的大环化合物。 这些化合物可用于治疗丙型肝炎病毒感染。
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公开(公告)号：US20080242701A1
公开(公告)日：2008-10-02
申请号：US12132254
申请日：2008-06-03
Applicant: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
Inventor： Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
IPC: A61K31/4709 , A61K31/4439 , A61K31/427 , A61P17/06
CPC classification number: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: This invention relates to treating cancer or an angiogenesis-related disease using a compound of formula 1: wherein R1, R2, R3, R4, and n are defined herein.
Abstract translation: 本发明涉及使用式1化合物治疗癌症或血管发生相关疾病：其中R 1，R 2，R 3， R 4，和n在本文中定义。
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公开(公告)号：US20080108632A1
公开(公告)日：2008-05-08
申请号：US11934151
申请日：2007-11-02
Applicant: Chu-chung Lin , Pei-chin Cheng , Yo-chin Liu , Chen-fu Liu , Chi-Hsin Richard King
Inventor： Chu-chung Lin , Pei-chin Cheng , Yo-chin Liu , Chen-fu Liu , Chi-Hsin Richard King
IPC: A61K31/4015 , A61K31/427 , A61K31/497 , C07D241/12 , C07D417/14 , C07D487/04
CPC classification number: C07D491/10 , C07D487/10 , C07D487/20 , C07D513/10
Abstract: This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
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公开(公告)号：US20060241140A1
公开(公告)日：2006-10-26
申请号：US11472064
申请日：2006-06-21
Applicant: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
Inventor： Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
IPC: A61K31/4709 , A61K31/4439 , A61K31/4178 , A61K31/4172 , C07D409/02 , C07D417/02 , C07D403/02
CPC classification number: C07D233/88 , C07D409/04 , C07D417/04 , C07D417/14
Abstract: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
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Patent Agency Ranking
公开(公告)号：US07462723B2
公开(公告)日：2008-12-09
申请号：US11472064
申请日：2006-06-21
Applicant: Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
Inventor： Chiung-Tong Chen , Wen-Tai Li , Der-Ren Hwang , Chu-Chung Lin
IPC: A61K31/427 , C07D417/04
CPC classification number: C07D233/88 , C07D409/04 , C07D417/04 , C07D417/14
Abstract: The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.
Abstract translation: 本发明涉及新的咪唑氨基化合物。 还公开了通过使用这些化合物之一和含有这些化合物之一的药物组合物来治疗癌症的方法。
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公开(公告)号：US07183413B2
公开(公告)日：2007-02-27
申请号：US10819646
申请日：2004-04-06
Applicant: Chu-Chung Lin , Jen-Fuh Liu , Chih-Wei Chang , Shu-Jen Chen , Yibin Xiang , Pei-Chin Cheng , Jiing-Jyh Jan
Inventor： Chu-Chung Lin , Jen-Fuh Liu , Chih-Wei Chang , Shu-Jen Chen , Yibin Xiang , Pei-Chin Cheng , Jiing-Jyh Jan
IPC: C07D215/16 , C07D215/38
CPC classification number: C07D401/14 , A61K31/4745 , A61K31/519 , C07D215/42 , C07D215/44 , C07D215/46 , C07D219/12 , C07D221/16 , C07D401/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in the specification.
Abstract translation: 本发明涉及用与CXCR3受体结合的某些氨基喹啉化合物治疗炎症和免疫疾病。 氨基喹啉化合物被下面所示的式（I）覆盖。 每个变量在规范中定义。
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公开(公告)号：US20060036093A1
公开(公告)日：2006-02-16
申请号：US11204792
申请日：2005-08-16
Applicant: Chu-Chung Lin , Hong-Chuan Chen , Kuang-Yuan Lee , Ying-Huey Huang , Yang-Ping Fan , Yibin Xiang
Inventor： Chu-Chung Lin , Hong-Chuan Chen , Kuang-Yuan Lee , Ying-Huey Huang , Yang-Ping Fan , Yibin Xiang
IPC: A61K31/519 , C07D239/72 , C07D487/02
CPC classification number: C07D471/04 , C07D239/90 , C07D239/95 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/14 , C07D495/04
Abstract: This invention relates to treating inflammatory and immune diseases with certain pyrimidinone compounds that bind to CXCR3 receptors. The pyrimidinone compounds are covered by the formula (I) shown below. Each variable is defined in the specification.
Abstract translation: 本发明涉及用与CXCR3受体结合的某些嘧啶酮化合物治疗炎症和免疫疾病。 嘧啶酮化合物被下面所示的式（I）覆盖。 每个变量在规范中定义。
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公开(公告)号：US20050234098A1
公开(公告)日：2005-10-20
申请号：US11145628
申请日：2005-06-06
Applicant: Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
Inventor： Chiung-Tong Chen , Shu-Jen Chen , Ming-Chu Hsu , Der-Ren Hwang , Wen-Tai Li , Chu-Chung Lin
IPC: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/4709 , A61K31/405 , A61K31/422 , A61K31/427 , A61K31/433 , C07D413/02 , C07D417/02 , C07D43/02
CPC classification number: C07D401/12 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: This invention relates to novel heteroatom containing compounds and compositions thereof, and their use for the prevention and treatment of disease. The invention also provides for methods of making the compounds. The invention is based on the discovery that certain heteroatom containing compounds, 3-oxoacetamideindolyl compounds, have potent anticancer, cytotoxic, and anti-angiogenic activity.
Abstract translation: 本发明涉及含杂原子的化合物及其组合物及其用于预防和治疗疾病的用途。 本发明还提供了制备化合物的方法。 本发明基于以下发现：某些含杂原子的化合物3-氧代乙酰胺吲哚基化合物具有有效的抗癌，细胞毒性和抗血管生成活性。
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公开(公告)号：US20090286814A1
公开(公告)日：2009-11-19
申请号：US12264508
申请日：2008-11-04
Applicant: Chu-chung Lin , Kuang-Yuan Lee , Yo-chin Liu , Pin Lo , Rong-Jiunn Chen , Chen-Fu Liu , Chih-Ming Chen , Chi-Hsin Richard King
Inventor： Chu-chung Lin , Kuang-Yuan Lee , Yo-chin Liu , Pin Lo , Rong-Jiunn Chen , Chen-Fu Liu , Chih-Ming Chen , Chi-Hsin Richard King
IPC: A61K31/519 , C07D239/70 , C07D215/00 , A61K31/4709 , A61P31/12
CPC classification number: C07K5/0804 , C07D487/04 , C07D519/00 , C07K5/081
Abstract: This invention relates to macrocyclic compounds of formula (I) or (II) shown in the specification. These compounds can be used to treat hepatitis C virus infection.
Abstract translation: 本发明涉及说明书中所示的式（I）或（II）的大环化合物。 这些化合物可用于治疗丙型肝炎病毒感染。
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