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公开(公告)号：US20180230114A1
公开(公告)日：2018-08-16
申请号：US15750067
申请日：2016-08-04
发明人： Jaekwang Lee , Yuntae Kim , Chang Sik Lee , Hyeseung Song , Dal-Yong Gwak , Jaeyoung Lee , Jung Taek Oh , Chang Gon Lee , Il Hyang Kim
IPC分类号： C07D271/10
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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2.发明申请公开(公告)号：US20180215743A1
公开(公告)日：2018-08-02
申请号：US15748081
申请日：2016-07-27
发明人： Jaekwang Lee , Moo Sung Ko , Younghue Han , Yuntae Kim
IPC分类号： C07D413/10 , C07D413/12
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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公开(公告)号：US11420950B2
公开(公告)日：2022-08-23
申请号：US15575672
申请日：2016-05-20
发明人： Changsik Lee , Jaekwang Lee , Hyeseung Song , Daekwon Bae , Nina Ha , Hyang Kim, II
IPC分类号： C07D295/215 , A61P37/00 , A61P9/00 , A61P35/00 , C07D241/04 , C07D471/10 , C07D211/18 , C07D211/22 , C07D211/58 , C07D211/62 , C07D213/36 , C07D295/205 , C07D211/96 , C07D211/54
摘要： The present invention relates to novel heterocyclicalkyl derivatives having histone deacetylase (HDAC) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel heterocyclicalkyl derivatives. The novel heterocyclicalkyl derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be effectively used for the treatment of histone deacetylase-mediated diseases, such as cell proliferative diseases, inflammatory diseases, autosomal dominant diseases, genetic metabolic diseases, autoimmune diseases, acute/chronic neurological disease, hypertrophy, heart failure, ocular diseases, or neurodegenerative diseases.
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公开(公告)号：US10538498B2
公开(公告)日：2020-01-21
申请号：US15747952
申请日：2016-07-27
发明人： Jaekwang Lee , Younghue Han , Yuntae Kim , Daekyu Choi , Jaeki Min , Miseon Bae , Hyunmo Yang , Dohoon Kim
IPC分类号： C07D271/10 , C07D413/12 , C07D413/14 , C07D413/04 , C07D417/12 , C07D513/04 , A61P25/00 , A61P35/00 , A61P37/00
摘要： The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.
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公开(公告)号：US10464911B2
公开(公告)日：2019-11-05
申请号：US15747850
申请日：2016-07-27
发明人： Jaekwang Lee , Younghue Han , Yuntae Kim , Jaeki Min , Miseon Bae , Dohoon Kim , Seokmin Jin , Jangbeen Kyung
IPC分类号： C07D271/10 , C07D413/14 , C07D413/12 , C07D471/10 , C07D413/04 , A61P31/00 , A61P25/00 , A61P11/00 , A61P3/00 , A61P9/00 , A61P35/00 , A61P17/00 , A61P5/00
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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公开(公告)号：US09650379B2
公开(公告)日：2017-05-16
申请号：US15103597
申请日：2014-12-12
发明人： Changsik Lee , Hyun-Mo Yang , Changkon Lee , Miseon Bae , Soyoung Kim , Youngil Choi , Nina Ha , Jaekwang Lee , Jungtaek Oh , Hyeseung Song , Ilhyang Kim , Daekyu Choi , Jaeki Min , Hyojin Lim , Daekwon Bae
IPC分类号： C07D471/06 , A61K31/437 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to novel azaindole derivatives, and more particularly, to novel azaindole derivatives having histone deacetylase (HDAC) inhibitory activity, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof or solvates thereof, the use thereof for the preparation of pharmaceutical compositions, pharmaceutical compositions containing the same, a method of treating disease using the pharmaceutical compositions, and methods for preparing the novel azaindole derivatives. The novel azaindole derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be used as agents for treating malignant tumor diseases, inflammatory diseases, rheumatoid arthritis, and neurodegenerative diseases.
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公开(公告)号：US10584117B2
公开(公告)日：2020-03-10
申请号：US15748081
申请日：2016-07-27
发明人： Jaekwang Lee , Moo Sung Ko , Younghue Han , Yuntae Kim
IPC分类号： C07D413/10 , A61K31/4245 , C07D413/12 , C07D271/10 , C07D205/04 , C07D213/02
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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公开(公告)号：US20180251437A1
公开(公告)日：2018-09-06
申请号：US15747952
申请日：2016-07-27
发明人： Jaekwang Lee , Younghue Han , Yuntae Kim , Daekyu Choi , Jaeki Min , Miseon Bae , Hyunmo Yang , Dohoon Kim
IPC分类号： C07D271/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.
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公开(公告)号：US10717716B2
公开(公告)日：2020-07-21
申请号：US15750067
申请日：2016-08-04
发明人： Jaekwang Lee , Yuntae Kim , Chang Sik Lee , Hyeseung Song , Dal-Yong Gwak , Jaeyoung Lee , Jung Taek Oh , Chang Gon Lee , Il Hyang Kim
IPC分类号： C07D271/10 , C07D413/12 , C07D491/10 , C07D413/04 , A61P25/00 , C07D471/10 , A61P37/00 , C07D413/14 , C07D417/12 , A61P29/00 , C07D417/14 , A61P35/00
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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公开(公告)号：US20180230113A1
公开(公告)日：2018-08-16
申请号：US15747850
申请日：2016-07-27
发明人： Jaekwang Lee , Younghue Han , Yuntae Kim , Jaeki Min , Miseon Bae , Dohoon Kim , Seokmin Jin , Jangbeen Kyung
IPC分类号： C07D271/10
摘要： The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.
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