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公开(公告)号：US09878986B2
公开(公告)日：2018-01-30
申请号：US14785812
申请日：2014-04-29
发明人： Changsik Lee , Hyun-Mo Yang , Hojin Choi , Dohoon Kim , Soyoung Kim , Nina Ha , Hyojin Lim , Eunhee Ko , Seongae Yoon , Daekwon Bae
IPC分类号： C07D231/56 , C07D209/14 , C07D213/40 , C07D401/12 , C07D403/12 , C07D413/12 , C07D239/26 , C07D215/12 , C07D213/75 , C07D295/215 , C07D239/42 , C07D213/74 , C07D309/08 , C07D309/10 , C07D317/58 , C07D405/12 , C07D407/12 , C07D417/12 , C07D265/30 , C07D319/18 , C07D207/08 , C07D207/10 , C07D209/08 , C07D211/26 , C07D211/46 , C07D211/52
CPC分类号： C07D231/56 , C07D207/08 , C07D207/10 , C07D209/08 , C07D209/14 , C07D211/26 , C07D211/46 , C07D211/52 , C07D213/40 , C07D213/74 , C07D213/75 , C07D215/12 , C07D239/26 , C07D239/42 , C07D265/30 , C07D295/215 , C07D309/08 , C07D309/10 , C07D317/58 , C07D319/18 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12
摘要： Provided are urea derivatives of Formula I: with histone deacetylase (HDAC) inhibitory activity, optical isomers thereof, pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising the same. The provided urea derivatives of Formula I are selective histone deacetylase (HDAC) inhibitors and are effective for the treatment of histone deacetylase-mediated diseases such as malignant tumors, inflammatory diseases, rheumatoid arthritis, and neurodegeneration.
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公开(公告)号：US20220008414A1
公开(公告)日：2022-01-13
申请号：US17296008
申请日：2019-11-22
发明人： Young II Choi , Nina Ha , Ju Young Song , Min Cheol Kim , Daekwon Bae , Ji Yeon Baek
IPC分类号： A61K31/496 , A61P25/02 , A61K31/495
摘要： The present invention relates to a pharmaceutical composition for preventing or treating CMT disease, comprising histone deacetylase 6 inhibitor. The pharmaceutical composition according to the present invention has histone deacetylase 6 (HDAC6) inhibitory activity and thus is effective in preventing or treating CMT disease.
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3.发明授权公开(公告)号：US10287255B2
公开(公告)日：2019-05-14
申请号：US15125256
申请日：2015-03-12
发明人： Hyeseung Song , Changgon Lee , Dalyong Kwak , Jaeyoung Lee , Suyeal Bae , Yuntae Kim , Daekwon Bae , Nina Ha , Miseon Bae , Jihyun Kim
IPC分类号： C07D241/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , A61K31/496 , A61K31/5375
摘要： A compound of formula (I), having histone deacetylase 6 (HDAC6) inhibitory activity, wherein X, Q, N, R1, R2, L, and n are as described, isomers thereof, or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions comprising the same, a method of treating disease using the composition, and methods for preparing the novel compounds. The novel compounds according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity, and are effective for the prevention or treatment of HDAC6-associated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological diseases and neurodegenerative disorders.
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公开(公告)号：US20220296599A1
公开(公告)日：2022-09-22
申请号：US17284591
申请日：2019-10-11
发明人： Young II Choi , Nina Ha , Daekwon Bae , Dong Hyeon Suh
IPC分类号： A61K31/519 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/551 , A61K31/397 , A61K31/40 , A61K31/553 , A61K31/4439 , A61K31/444 , A61K31/4433 , A61K31/357 , A61P19/02
摘要： The present invention relates to a pharmaceutical composition for preventing or treating inflammatory rheumatic diseases, comprising a histone deacetylase inhibitor and methotrexate as an effective component; a treatment method using the composition; and a use of the composition in preparing a drug for treating inflammatory rheumatic diseases, wherein the pharmaceutical composition according to the present invention shows an excellent effect on preventing or treating inflammatory rheumatic diseases.
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公开(公告)号：US09650379B2
公开(公告)日：2017-05-16
申请号：US15103597
申请日：2014-12-12
发明人： Changsik Lee , Hyun-Mo Yang , Changkon Lee , Miseon Bae , Soyoung Kim , Youngil Choi , Nina Ha , Jaekwang Lee , Jungtaek Oh , Hyeseung Song , Ilhyang Kim , Daekyu Choi , Jaeki Min , Hyojin Lim , Daekwon Bae
IPC分类号： C07D471/06 , A61K31/437 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to novel azaindole derivatives, and more particularly, to novel azaindole derivatives having histone deacetylase (HDAC) inhibitory activity, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof or solvates thereof, the use thereof for the preparation of pharmaceutical compositions, pharmaceutical compositions containing the same, a method of treating disease using the pharmaceutical compositions, and methods for preparing the novel azaindole derivatives. The novel azaindole derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be used as agents for treating malignant tumor diseases, inflammatory diseases, rheumatoid arthritis, and neurodegenerative diseases.
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公开(公告)号：US11571426B2
公开(公告)日：2023-02-07
申请号：US16766578
申请日：2018-11-23
发明人： Young Il Choi , Nina Ha , Daekwon Bae
IPC分类号： A61K31/5375 , A61P37/02 , A61K31/397 , A61K31/495 , A61K31/5377
摘要： The present invention relates to a pharmaceutical composition for preventing or treating lupus, containing a compound represented by a formula I, an optical isomer thereof or a pharmaceutically acceptable salt thereof as an effective component, as well as a treatment method using the compound, and use of the compound in the manufacture of a medicament for treating lupus. The pharmaceutical composition according to the present invention shows an excellent effect of preventing or treating lupus.
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公开(公告)号：US11420950B2
公开(公告)日：2022-08-23
申请号：US15575672
申请日：2016-05-20
发明人： Changsik Lee , Jaekwang Lee , Hyeseung Song , Daekwon Bae , Nina Ha , Hyang Kim, II
IPC分类号： C07D295/215 , A61P37/00 , A61P9/00 , A61P35/00 , C07D241/04 , C07D471/10 , C07D211/18 , C07D211/22 , C07D211/58 , C07D211/62 , C07D213/36 , C07D295/205 , C07D211/96 , C07D211/54
摘要： The present invention relates to novel heterocyclicalkyl derivatives having histone deacetylase (HDAC) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel heterocyclicalkyl derivatives. The novel heterocyclicalkyl derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be effectively used for the treatment of histone deacetylase-mediated diseases, such as cell proliferative diseases, inflammatory diseases, autosomal dominant diseases, genetic metabolic diseases, autoimmune diseases, acute/chronic neurological disease, hypertrophy, heart failure, ocular diseases, or neurodegenerative diseases.
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公开(公告)号：US20200368245A1
公开(公告)日：2020-11-26
申请号：US16766578
申请日：2018-11-23
发明人： Young Il Choi , Nina Ha , Daekwon Bae
IPC分类号： A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/397 , A61P37/02
摘要： The present invention relates to a pharmaceutical composition for preventing or treating lupus, containing a compound represented by a formula I, an optical isomer thereof or a pharmaceutically acceptable salt thereof as an effective component, as well as a treatment method using the compound, and use of the compound in the manufacture of a medicament for treating lupus. The pharmaceutical composition according to the present invention shows an excellent effect of preventing or treating lupus.
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