公开(公告)号：US20080292667A1

公开(公告)日：2008-11-27

申请号：US12185860

申请日：2008-08-05

申请人： Chong-Pyoung Chung ,  Won-Ho Park ,  Kyoung-Hwa Kim ,  Lim Jeong

发明人： Chong-Pyoung Chung ,  Won-Ho Park ,  Kyoung-Hwa Kim ,  Lim Jeong

IPC分类号： A61K9/10 ,  A61F2/28 ,  A61P19/00

CPC分类号： A61L27/3604 ,  A61F2/2846 ,  A61F2/3094 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61L27/58 ,  A61L31/005 ,  A61L31/148 ,  A61L2400/12 ,  A61L2430/02 ,  C12N5/0654 ,  C12N2533/50

摘要： The present invention relates to a membrane for guided bone tissue regeneration and, more particularly, to a membrane for guided bone tissue regeneration having a structure that silk fibroin nanofibers obtained by removing sericin from silk fibers are formed as a nonwoven, and a manufacturing method thereof.A membrane for guided bone tissue regeneration according to the present invention has a predetermined strength, biocompatibility, and biodegradability, and may maintain a sustained drug release system, when drugs are added in the manufacturing process. Additionally, a membrane for guided bone tissue regeneration according to the present invention may be modified corresponding to the condition of usage, because a thickness of the membrane may be adjusted by controlling fineness of nanofibers, compactness of nanofibers, and pore size of a multiporous structure may be adjusted, in a nonwoven manufacturing process. A nanofibrous membrane for guided bone tissue regeneration according to the present invention is manufactured by freezing rapidly, drying a silk fibroin solution obtained by removing sericin from silk fibers, and by electrospinning after dissolving the dried silk fibroin in an electrospinning solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thereby effective in regeneration of damaged periodontal tissues.

摘要翻译： 本发明涉及一种用于引导骨组织再生的膜，更具体地，涉及一种用于引导骨组织再生的膜，其具有通过从丝纤维除去丝胶蛋白而获得的丝素蛋白纳米纤维作为非织造材料的方法及其制造方法 。 根据本发明的用于引导骨组织再生的膜具有预定的强度，生物相容性和生物降解性，并且当在制造过程中添加药物时，可以维持持续的药物释放系统。 此外，根据本发明的用于引导骨组织再生的膜可以根据使用条件进行修改，因为可以通过控制纳米纤维的细度，纳米纤维的紧密度和多孔结构的孔径来调节膜的厚度 可以在无纺布制造过程中进行调整。 根据本发明的用于引导骨组织再生的纳米纤维膜通过快速冷冻来制造，干燥通过从丝纤维中除去丝胶蛋白得到的丝素蛋白溶液，并且在将干燥的丝素蛋白溶解在静电纺丝溶剂中后通过静电纺丝制造。 根据本发明的膜具有优异的粘附性和透气性，从而有效地再生损伤的牙周组织。

公开(公告)号：US20060095137A1

公开(公告)日：2006-05-04

申请号：US11229138

申请日：2005-09-16

申请人： Chong-Pyoung Chung ,  Won-Ho Park ,  Kyoung-Hwa Kim ,  Lim Jeong

发明人： Chong-Pyoung Chung ,  Won-Ho Park ,  Kyoung-Hwa Kim ,  Lim Jeong

IPC分类号： A61F2/28 ,  C12N5/08

CPC分类号： A61L27/3604 ,  A61F2/2846 ,  A61F2/3094 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61L27/58 ,  A61L31/005 ,  A61L31/148 ,  A61L2400/12 ,  A61L2430/02 ,  C12N5/0654 ,  C12N2533/50

摘要： The present invention relates to a membrane for guided bone tissue regeneration and, more particularly, to a membrane for guided bone tissue regeneration having a structure that silk fibroin nanofibers obtained by removing sericin from silk fibers are formed as a nonwoven, and a manufacturing method thereof. A membrane for guided bone tissue regeneration according to the present invention has a predetermined strength, biocompatibility, and biodegradability, and may maintain a sustained drug release system, when drugs are added in the manufacturing process. Additionally, a membrane for guided bone tissue regeneration according to the present invention may be modified corresponding to the condition of usage, because a thickness of the membrane may be adjusted by controlling fineness of nanofibers, compactness of nanofibers, and pore size of a multiporous structure may be adjusted, in a nonwoven manufacturing process. A nanofibrous membrane for guided bone tissue regeneration according to the present invention is manufactured by freezing rapidly, drying a silk fibroin solution obtained by removing sericin from silk fibers, and by electrospinning after dissolving the dried silk fibroin in an electrospinning solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thereby effective in regeneration of damaged periodontal tissues.

摘要翻译： 本发明涉及一种用于引导骨组织再生的膜，更具体地，涉及一种用于引导骨组织再生的膜，其具有通过从丝纤维除去丝胶蛋白而获得的丝素蛋白纳米纤维作为非织造材料的方法及其制造方法 。 根据本发明的用于引导骨组织再生的膜具有预定的强度，生物相容性和生物降解性，并且当在制造过程中添加药物时，可以维持持续的药物释放系统。 此外，根据本发明的用于引导骨组织再生的膜可以根据使用条件进行修改，因为可以通过控制纳米纤维的细度，纳米纤维的紧密度和多孔结构的孔径来调节膜的厚度 可以在无纺布制造过程中进行调整。 根据本发明的用于引导骨组织再生的纳米纤维膜通过快速冷冻来制造，干燥通过从丝纤维中除去丝胶蛋白得到的丝素蛋白溶液，并将干燥的丝素蛋白溶解在静电纺丝溶剂中后通过静电纺丝。 根据本发明的膜具有优异的粘附性和透气性，从而有效地再生损伤的牙周组织。