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1.发明申请Nonwoven Nanofibrous Membranes of Silk Fibroin for Guided Bone Tissue Regeneration and Their Preparation Method 审中-公开用于引导骨组织再生的丝素蛋白无纺纳米纤维膜及其制备方法公开(公告)号：US20080292667A1
公开(公告)日：2008-11-27
申请号：US12185860
申请日：2008-08-05
申请人： Chong-Pyoung Chung , Won-Ho Park , Kyoung-Hwa Kim , Lim Jeong
发明人： Chong-Pyoung Chung , Won-Ho Park , Kyoung-Hwa Kim , Lim Jeong
CPC分类号： A61L27/3604 , A61F2/2846 , A61F2/3094 , A61F2002/2817 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61L27/58 , A61L31/005 , A61L31/148 , A61L2400/12 , A61L2430/02 , C12N5/0654 , C12N2533/50
摘要： The present invention relates to a membrane for guided bone tissue regeneration and, more particularly, to a membrane for guided bone tissue regeneration having a structure that silk fibroin nanofibers obtained by removing sericin from silk fibers are formed as a nonwoven, and a manufacturing method thereof.A membrane for guided bone tissue regeneration according to the present invention has a predetermined strength, biocompatibility, and biodegradability, and may maintain a sustained drug release system, when drugs are added in the manufacturing process. Additionally, a membrane for guided bone tissue regeneration according to the present invention may be modified corresponding to the condition of usage, because a thickness of the membrane may be adjusted by controlling fineness of nanofibers, compactness of nanofibers, and pore size of a multiporous structure may be adjusted, in a nonwoven manufacturing process. A nanofibrous membrane for guided bone tissue regeneration according to the present invention is manufactured by freezing rapidly, drying a silk fibroin solution obtained by removing sericin from silk fibers, and by electrospinning after dissolving the dried silk fibroin in an electrospinning solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thereby effective in regeneration of damaged periodontal tissues.
摘要翻译： 本发明涉及一种用于引导骨组织再生的膜，更具体地，涉及一种用于引导骨组织再生的膜，其具有通过从丝纤维除去丝胶蛋白而获得的丝素蛋白纳米纤维作为非织造材料的方法及其制造方法 。 根据本发明的用于引导骨组织再生的膜具有预定的强度，生物相容性和生物降解性，并且当在制造过程中添加药物时，可以维持持续的药物释放系统。 此外，根据本发明的用于引导骨组织再生的膜可以根据使用条件进行修改，因为可以通过控制纳米纤维的细度，纳米纤维的紧密度和多孔结构的孔径来调节膜的厚度 可以在无纺布制造过程中进行调整。 根据本发明的用于引导骨组织再生的纳米纤维膜通过快速冷冻来制造，干燥通过从丝纤维中除去丝胶蛋白得到的丝素蛋白溶液，并且在将干燥的丝素蛋白溶解在静电纺丝溶剂中后通过静电纺丝制造。 根据本发明的膜具有优异的粘附性和透气性，从而有效地再生损伤的牙周组织。
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2.发明申请Nanofibrous nonwoven membrane of silk fibroin for guided bone tissue regeneration and manufacturing method thereof 审中-公开用于引导骨组织再生的丝素蛋白的无纺非织造膜及其制造方法公开(公告)号：US20060095137A1
公开(公告)日：2006-05-04
申请号：US11229138
申请日：2005-09-16
申请人： Chong-Pyoung Chung , Won-Ho Park , Kyoung-Hwa Kim , Lim Jeong
发明人： Chong-Pyoung Chung , Won-Ho Park , Kyoung-Hwa Kim , Lim Jeong
CPC分类号： A61L27/3604 , A61F2/2846 , A61F2/3094 , A61F2002/2817 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61L27/58 , A61L31/005 , A61L31/148 , A61L2400/12 , A61L2430/02 , C12N5/0654 , C12N2533/50
摘要： The present invention relates to a membrane for guided bone tissue regeneration and, more particularly, to a membrane for guided bone tissue regeneration having a structure that silk fibroin nanofibers obtained by removing sericin from silk fibers are formed as a nonwoven, and a manufacturing method thereof. A membrane for guided bone tissue regeneration according to the present invention has a predetermined strength, biocompatibility, and biodegradability, and may maintain a sustained drug release system, when drugs are added in the manufacturing process. Additionally, a membrane for guided bone tissue regeneration according to the present invention may be modified corresponding to the condition of usage, because a thickness of the membrane may be adjusted by controlling fineness of nanofibers, compactness of nanofibers, and pore size of a multiporous structure may be adjusted, in a nonwoven manufacturing process. A nanofibrous membrane for guided bone tissue regeneration according to the present invention is manufactured by freezing rapidly, drying a silk fibroin solution obtained by removing sericin from silk fibers, and by electrospinning after dissolving the dried silk fibroin in an electrospinning solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thereby effective in regeneration of damaged periodontal tissues.
摘要翻译： 本发明涉及一种用于引导骨组织再生的膜，更具体地，涉及一种用于引导骨组织再生的膜，其具有通过从丝纤维除去丝胶蛋白而获得的丝素蛋白纳米纤维作为非织造材料的方法及其制造方法 。 根据本发明的用于引导骨组织再生的膜具有预定的强度，生物相容性和生物降解性，并且当在制造过程中添加药物时，可以维持持续的药物释放系统。 此外，根据本发明的用于引导骨组织再生的膜可以根据使用条件进行修改，因为可以通过控制纳米纤维的细度，纳米纤维的紧密度和多孔结构的孔径来调节膜的厚度 可以在无纺布制造过程中进行调整。 根据本发明的用于引导骨组织再生的纳米纤维膜通过快速冷冻来制造，干燥通过从丝纤维中除去丝胶蛋白得到的丝素蛋白溶液，并将干燥的丝素蛋白溶解在静电纺丝溶剂中后通过静电纺丝。 根据本发明的膜具有优异的粘附性和透气性，从而有效地再生损伤的牙周组织。
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3.发明授权公开(公告)号：US08546529B2
公开(公告)日：2013-10-01
申请号：US12663399
申请日：2008-06-05
CPC分类号： A61L27/52 , A61L27/227 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.
摘要翻译： 本发明涉及含有骨形成增强肽的可注射骨再生材料，更具体地，涉及可注射骨再生材料，其中，基本上含有SEQ ID NO：1至 SEQ ID NO：28被结合或混合到选自壳聚糖，藻酸，丝素蛋白，丙二醇，丙二醇藻酸，泊洛沙姆，硫酸软骨素及其组合中的凝胶形成基材。 根据本发明的可注射骨再生材料可以增加骨髓基质细胞和成骨细胞分化成骨组织，从而通过能够促进骨组织分化和牙周组织再生的肽最大化组织再生。 可注射骨再生材料为凝胶形式，因此可以应用于诸如植入物等各种医疗装置的表面，并且可以与骨移植物颗粒混合使用，从而可以增加治疗效果 的现有医疗装置以最大化组织再生效果。
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公开(公告)号：US20130224128A1
公开(公告)日：2013-08-29
申请号：US13581073
申请日：2011-02-28
IPC分类号： A61K6/00
CPC分类号： A61K6/0035 , A61K8/39 , A61K8/64 , A61K8/731 , A61Q11/00 , A61Q17/005
摘要： The present invention relates to a dental cleanser composition for improving adhesion to teeth, and more particularly to, a dental cleanser composition which functions to remove not only a smear layer from the dentin surface of an exposed tooth root, but also oral bacteria, and thus is effective in improving adhesion to teeth in periodontal surgery. The present invention provides a dental cleanser composition containing sodium ethylene diaminotetraacetate and octyl phenol ethoxylate which is a surfactant. Sodium ethylene diaminotetraacetate in the composition functions to remove a smear layer on the tooth root surface and has antibacterial activity, and octyl phenol ethoxylate in the composition functions to lipopolysaccharide. Thus, the composition improves adhesion to teeth in periodontal surgery.
摘要翻译： 本发明涉及一种牙齿清洁剂组合物，其用于改善与牙齿的粘附性，更具体地说，涉及一种牙科清洁剂组合物，其不仅能够从暴露的牙根的牙本质表面除去涂抹层，而且还可以口服细菌， 有效改善牙周牙周围牙根的粘连。 本发明提供一种含有乙二胺四乙酸钠和辛基酚乙氧基化物的牙科清洁剂组合物，其是表面活性剂。 组合物中的乙二胺四乙酸钠起到除去牙根表面上的涂抹层的作用，具有抗菌活性，并且组合物中的辛基酚乙氧基化物对脂多糖起作用。 因此，该组合物在牙周手术中改善对牙齿的粘附性。
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5.发明授权Bone graft and scaffolding materials immobilized with type I collagen binding peptides 有权用I型胶原结合肽固定的骨移植物和脚手架材料公开(公告)号：US08349804B2
公开(公告)日：2013-01-08
申请号：US12278009
申请日：2007-01-19
CPC分类号： A61L27/10 , A61L27/34 , A61L27/54 , A61L2430/02
摘要： The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide. In the inventive bone graft material and scaffold for tissue engineering applications, the cells related to regeneration by collagen binding-inducing peptide adhered to the surface, promote an adhesion of type I collagen binding-inducing peptide (main ingredients of extracellular matrix) to increase differentiation rate into bone tissues, and promote a calcification which is last step of bone regeneration to maximize a tissue regeneration finally.
摘要翻译： 本发明涉及一种药物组合物，其包含骨移植材料，用于组织工程应用的支架和具有固定在表面上的骨钙化促进肽的I型胶原结合肽，更具体地涉及骨移植材料和支架 用于组织工程应用（以下称为支架），其具有与固定在表面上的I型胶原特异性结合的肽，以及用于回收含有I型胶原结合诱导肽的组织再生的药物组合物。 在用于组织工程应用的本发明的骨移植物材料和支架中，与通过胶原结合诱导肽再生的细胞粘附到表面上，促进I型胶原结合诱导肽（细胞外基质的主要成分）的粘附以增加分化 进入骨组织，并促进钙化，这是骨再生的最后一步，最终最大限度地发挥组织再生。
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6.发明申请COMPLEX OF CELL TRANSLOCATIONAL PEPTIDE AND MAGNETIC NANOPARTICLES AND USE THEREOF 审中-公开细胞转移肽和磁性纳米颗粒的复合物及其用途公开(公告)号：US20100298536A1
公开(公告)日：2010-11-25
申请号：US12681027
申请日：2008-10-02
CPC分类号： A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
摘要： The present invention relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex and the use thereof. More specifically, relates to a cell-penetrating peptide/fluorescence-labeled magnetic nanoparticle complex in which a cell-penetrating peptide is chemically linked to a fluorescence-labeled magnetic nanoparticle, such that fluorescence-labeled magnetic nanoparticle can be stably introduced directly into cells without endocytosis, and a composition for cell imaging containing the complex. The disclosed invention suggests an innovative therapeutic technology which shows high stability, maximizes the effect of imaging diagnosis through optimal targeting and minimizes side effects, unlike existing viral peptide transporters.
摘要翻译： 本发明涉及细胞穿透肽/荧光标记的磁性纳米颗粒复合物及其用途。 更具体地，涉及细胞穿透肽/荧光标记的磁性纳米颗粒复合物，其中细胞穿透肽与荧光标记的磁性纳米颗粒化学连接，使得荧光标记的磁性纳米颗粒可以直接稳定地引入到细胞中而没有 内吞作用，以及含有该复合物的细胞成像用组合物。 所公开的发明提出了一种创新的治疗技术，其显示出高稳定性，与现有的病毒肽转运蛋白不同，通过最佳靶向使得成像诊断的效果最大化并且最小化副作用。
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7.发明授权公开(公告)号：US09408920B2
公开(公告)日：2016-08-09
申请号：US14119160
申请日：2011-12-16
CPC分类号： A61K47/48246 , A61K47/64 , C07K14/4702 , C07K14/51 , C07K2319/10 , C07K2319/21 , C07K2319/35 , C07K2319/73 , C12N9/0036 , C12N9/0089
摘要： The present invention relates to a cell permeable fusion protein for strengthening regenerative potential of stem cells, and more particularly to a cell permeable fusion protein for strengthening regenerative potential of stem cells for stimulating the differentiation of stem cells, inhibiting apoptosis, maintaining the functionality of stem cells and restoring the stress-inhibited functionality of stem cells.
摘要翻译： 本发明涉及一种用于增强干细胞再生潜力的细胞可渗透融合蛋白，更具体地涉及一种用于增强干细胞再生潜能以促进干细胞分化，抑制细胞凋亡，维持干细胞功能的细胞渗透融合蛋白 细胞并恢复干细胞的应激抑制功能。
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公开(公告)号：US09133246B2
公开(公告)日：2015-09-15
申请号：US14112929
申请日：2011-12-16
IPC分类号： A61K38/00 , C07K14/78 , C07K14/00 , A61L27/24 , A61L27/54 , A61L27/60 , C12N15/62 , C07K14/49 , C07K14/51 , C07K14/47 , C07K14/485
CPC分类号： C07K14/001 , A61K38/00 , A61L27/24 , A61L27/54 , A61L27/60 , A61L2300/252 , A61L2300/404 , A61L2300/80 , A61L2430/02 , C07K14/4723 , C07K14/485 , C07K14/49 , C07K14/51 , C07K14/78 , C07K2319/00 , C12N15/62
摘要： A collagen membrane having fusion protein bound thereto is described, in which the fusion protein includes collagen binding peptide and antibacterial peptide. The collagen membrane is usefully employed in vivo to promote cell migration, proliferation, and differentiation associated with bone tissue regeneration, for bone induction and regeneration. The fusion protein may also be applied to other collagenic graft materials, for use as a biomaterial for regenerating other tissues such as the skin.
摘要翻译： 描述了与其结合的融合蛋白的胶原膜，其中融合蛋白包括胶原结合肽和抗菌肽。 胶原膜在体内有用地用于促进与骨组织再生相关的细胞迁移，增殖和分化，用于骨诱导和再生。 融合蛋白也可以应用于其它胶原移植材料，用作再生其他组织如皮肤的生物材料。
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9.发明授权Peptide having the ability to regenerate bone tissue and for binding to apatite 有权具有再生骨组织和结合磷灰石的能力的肽公开(公告)号：US08853165B2
公开(公告)日：2014-10-07
申请号：US13821811
申请日：2011-03-09
IPC分类号： A61P19/08 , A61K38/16 , A61K38/10 , C07K17/02 , C07K17/14 , C07K14/00 , C07K7/08 , A61L27/12 , A61L27/22 , C07K14/52 , A61L27/54
CPC分类号： C07K14/52 , A61L27/12 , A61L27/22 , A61L27/54 , A61L2300/25
摘要： The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral. A composition for bone tissue regeneration containing the peptide is further provided.
摘要翻译： 本发明涉及具有骨组织再生能力并与磷灰石表面结合的肽。 更具体地，提供具有骨组织再生能力并且特异性结合磷灰石矿物表面的肽，其能够稳定地固定在磷灰石矿物的表面以保持有效活性并长时间显示出骨再生效果，通过将 具有骨组织再生能力的氨基酸序列和具有彼此磷灰石结合能力的氨基酸序列，从而提供具有磷灰石矿物表面的成骨作用和结合能力的肽。 还提供了含有该肽的骨组织再生用组合物。
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10.发明申请TARGET-ACTIVATED CELL/TISSUE-PENETRATING PEPTIDE FOR DELIVERY OF IMPERMEABLE COMPOUNDS AND USE THEREOF 有权用于递送不可化合物的靶向活化细胞/组织渗透肽及其用途公开(公告)号：US20120053129A1
公开(公告)日：2012-03-01
申请号：US13202317
申请日：2010-02-19
CPC分类号： C07K14/47 , A61K38/00 , A61K47/645 , A61K47/65 , C07K2319/10
摘要： The present invention relates to a target-activated cell/tissue-penetrating peptide for delivery of impermeable compounds (Target Activated Cell/tissue Translocation peptide for Impermeable Compound Strategy (TACTICS)), and the use thereof, and more particularly to a target-activated cell/tissue-penetrating peptide, which comprises (a) a protein transduction domain (PTD), (b) a masking domain and (c) a spacer having a cleavage site specific for a target cell/tissue enzyme and is provided with target selectivity so as to penetrate specifically into a target tissue, and to a conjugate of the peptide with a drug or drug-containing particles for imaging or therapeutic applications. Because the target-activated cell/tissue-penetrating peptide has target selectivity, the peptide-drug conjugate exhibits maximized imaging and therapeutic effects, and the non-specific distribution of the conjugate in vivo is inhibited, so that the side effects of the conjugate are minimized, the diagnostic effects of the conjugate are maximized, and the conjugate is useful for the treatment of disease.
摘要翻译： 本发明涉及用于递送不可渗透化合物的靶激活细胞/组织穿透肽（用于不透水复合策略的靶活化细胞/组织易位肽（TACTICS））及其用途，更具体地涉及靶激活 细胞/组织穿透肽，其包含（a）蛋白转导结构域（PTD），（b）掩蔽结构域和（c）具有针对靶细胞/组织酶特异性切割位点的间隔物，并提供靶标选择性 以便特异性地穿透靶组织，以及肽与药物或药物的颗粒的缀合物用于成像或治疗应用。 由于目标激活的细胞/组织穿透肽具有靶选择性，所以肽 - 药物缀合物表现出最大化的成像和治疗效果，并且体内缀合物的非特异性分布被抑制，使得缀合物的副作用为 最小化，缀合物的诊断效果最大化，并且缀合物可用于治疗疾病。
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