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公开(公告)号：US20110184340A1
公开(公告)日：2011-07-28
申请号：US13000830
申请日：2009-06-22
申请人： Kim Cheng Tan , Christian Gert Bluchel , Lay Leng Chew , Kee Kiat Chua , Lai Ching Helen Ho , Keng Hong Lee , Liutong Lin , Weng Cheong Roy Tang , Keng Mun Yue , Kim Jyh Wong , Cheng Lam Chua
发明人： Kim Cheng Tan , Christian Gert Bluchel , Lay Leng Chew , Kee Kiat Chua , Lai Ching Helen Ho , Keng Hong Lee , Liutong Lin , Weng Cheong Roy Tang , Keng Mun Yue , Kim Jyh Wong , Cheng Lam Chua
IPC分类号： A61M1/28
CPC分类号： A61M1/3679 , A61M1/1696 , A61M1/28 , A61M1/3687 , B01D15/206 , B01D15/362 , B01D15/363 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28052 , B01J39/12 , B01J41/10
摘要： There is provided a flow system of a dialysis device including a dialysate conduit which is capable of being in fluid communication with the peritoneal cavity of a patient's body and of being in fluid communication with a flow path, the flow path allowing dialysate to flow from a patient's body to a sorbent capable of removing contaminants within the dialysate in an outflow mode and in an inflow mode returning the dialysate substantially free of contaminants to the patient's body. The device also includes a pump for moving the dialysate along the flow path in both the outflow mode and inflow mode and a plurality of valves disposed along the flow path. There is also provided a portable dialysis device.
摘要翻译： 提供了一种透析装置的流动系统，其包括透析液导管，其能够与患者身体的腹膜腔流体连通并且与流动路径流体连通，所述流动路径允许透析液从 患者的身体到能够以流出模式去除透析液中的污染物并且在流入模式中将基本上没有污染物的透析液返回到患者身体的吸附剂。 该装置还包括用于在流出模式和流入模式中沿流动路径移动透析液的泵和沿流动路径设置的多个阀。 还提供便携式透析装置。
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公开(公告)号：US20140309584A1
公开(公告)日：2014-10-16
申请号：US13885273
申请日：2011-11-08
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61M1/1658 , A61M1/1696 , A61M2205/121 , A61M2205/123 , A61M2205/126 , A61M2205/128 , A61M2205/33 , A61M2205/7518 , A61M2209/088
摘要： A dialysis device is provided comprising a disposable housing having a dialysate flow path along which dialysate received from a patient is subjected to contaminant removal when in operation, wherein said disposable housing comprises a storage chamber in fluid communication with the dialysate flow path for storing the dialysate therein; a controller for controlling the operation of said disposable housing; an interface means capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate, and a fluid displacement means configured to move the dialysate along the dialysate flow path, wherein said fluid displacement means comprises a deformable diaphragm integrally formed with at least one wall of said storage chamber, wherein the flow path is fluidly sealed from the controller and interface means. A method of dialysis, a dialysis system and kits are also provided.
摘要翻译： 提供了一种透析装置，其包括具有透析液流动通道的一次性外壳，沿着该透析液流路从患者接收的透析液在操作时经受污染物去除，其中所述一次性外壳包括与用于储存透析液的透析液流动路径流体连通的储存室 其中 用于控制所述一次性外壳的操作的控制器; 接口装置，其能够可操作地联接所述控制器和所述一次性外壳以使得能够从所述透析液中除去污染物;以及流体移动装置，其被配置为沿所述透析液流动路径移动所述透析液，其中所述流体移动装置包括可变形隔膜， 所述储存室的至少一个壁，其中所述流动路径与所述控制器和接口装置流体密封。 还提供透析方法，透析系统和试剂盒。
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公开(公告)号：US09067017B2
公开(公告)日：2015-06-30
申请号：US13000830
申请日：2009-06-22
申请人： Kim Cheng Tan , Christian Gert Bluchel , Lay Leng Chew , Kee Kiat Chua , Lai Ching Helen Ho , Keng Hong Lee , Liutong Lin , Weng Cheong Roy Tang , Keng Mun Yue , Kim Jyh Wong , Cheng Lam Chua
发明人： Kim Cheng Tan , Christian Gert Bluchel , Lay Leng Chew , Kee Kiat Chua , Lai Ching Helen Ho , Keng Hong Lee , Liutong Lin , Weng Cheong Roy Tang , Keng Mun Yue , Kim Jyh Wong , Cheng Lam Chua
IPC分类号： A61M1/00 , A61M1/16 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28 , B01J39/12 , B01J41/10 , A61M1/28
CPC分类号： A61M1/3679 , A61M1/1696 , A61M1/28 , A61M1/3687 , B01D15/206 , B01D15/362 , B01D15/363 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28052 , B01J39/12 , B01J41/10
摘要： There is provided a flow system of a dialysis device including a dialysate conduit which is capable of being in fluid communication with the peritoneal cavity of a patient's body and of being in fluid communication with a flow path, the flow path allowing dialysate to flow from a patient's body to a sorbent capable of removing contaminants within the dialysate in an outflow mode and in an inflow mode returning the dialysate substantially free of contaminants to the patient's body. The device also includes a pump for moving the dialysate along the flow path in both the outflow mode and inflow mode and a plurality of valves disposed along the flow path. There is also provided a portable dialysis device.
摘要翻译： 提供了一种透析装置的流动系统，其包括透析液导管，其能够与患者身体的腹膜腔流体连通并且与流动路径流体连通，所述流动路径允许透析液从 患者的身体到能够以流出模式去除透析液中的污染物并且在流入模式中将基本上没有污染物的透析液返回到患者身体的吸附剂。 该装置还包括用于在流出模式和流入模式中沿流动路径移动透析液的泵和沿流动路径设置的多个阀。 还提供便携式透析装置。
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公开(公告)号：US20110171713A1
公开(公告)日：2011-07-14
申请号：US13000811
申请日：2009-06-22
CPC分类号： A61M1/3679 , A61M1/1696 , A61M1/28 , A61M1/3687 , B01D15/206 , B01D15/362 , B01D15/363 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28052 , B01J39/12 , B01J41/10
摘要： There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.
摘要翻译： 提供了用于从透析液中除去代谢废物的吸附剂，该吸附剂包含与阳离子交换颗粒混合的固定的尿毒症毒素处理酶颗粒层。
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公开(公告)号：US09242036B2
公开(公告)日：2016-01-26
申请号：US13000811
申请日：2009-06-22
IPC分类号： A61M1/30 , A61M1/16 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28 , B01J39/12 , B01J41/10 , A61M1/28
CPC分类号： A61M1/3679 , A61M1/1696 , A61M1/28 , A61M1/3687 , B01D15/206 , B01D15/362 , B01D15/363 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28052 , B01J39/12 , B01J41/10
摘要： There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.
摘要翻译： 提供了用于从透析液中除去代谢废物的吸附剂，该吸附剂包含与阳离子交换颗粒混合的固定的尿毒症毒素处理酶颗粒层。
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6.发明授权Substrate for immobilizing functional substances and method for preparing the same 有权用于固定功能性物质的底物及其制备方法公开(公告)号：US08561811B2
公开(公告)日：2013-10-22
申请号：US13837254
申请日：2013-03-15
IPC分类号： B01D39/00
CPC分类号： C12N11/12 , B01D61/243 , B01D67/0093 , B01D71/16 , B01J20/321 , B01J20/3212 , B01J20/3248 , B01J20/3251 , C12N11/06 , G01N33/54353
摘要： A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain including: a moiety R that is chemically coupled to the substrate, the moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker including at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed.
摘要翻译： 一种底物，其上设置有用于固定功能性分子的化合物，每种化合物具有包括：与基底化学偶联的部分R，部分R选自醚，酯，羰基，碳酸酯， 硫醚，二硫化物，亚磺酰基，磺酰基和碳硫基; 和通过包括至少一个亲核基团的连接体与部分R偶联的含环氧化物的部分。 还公开了制备基材和使用基材的方法。
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