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公开(公告)号：US07543481B2
公开(公告)日：2009-06-09
申请号：US10590838
申请日：2005-02-04
IPC分类号： G01N33/487 , G01N27/403
CPC分类号： B01L3/502715 , B01L3/502723 , B01L2200/0684 , B01L2300/0645 , B01L2300/0816 , B01L2300/0825 , B01L2300/0861 , B01L2300/0887 , B01L2400/0406 , G01N27/3272
摘要： A sensor for analyzing a fluid sample has a sample cavity for accepting sample fluid. At least one test region is disposed along the sample cavity, and at least one vent fulfills the dual function of venting the sample cavity and guiding the sample fluid in the sample cavity via appropriate location and geometry of at least one sample guide edge.
摘要翻译： 用于分析流体样品的传感器具有用于接收样品流体的样品腔。 沿着样品腔设置至少一个测试区域，并且至少一个排气口满足通过样品空腔的双重功能，并通过至少一个样品引导边缘的适当位置和几何形状来引导样品腔中的样品流体。
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公开(公告)号：US20070062262A1
公开(公告)日：2007-03-22
申请号：US10590838
申请日：2005-02-04
申请人： Christina Blaschke , Daniel Brown , Sung-Kwon Jung
发明人： Christina Blaschke , Daniel Brown , Sung-Kwon Jung
IPC分类号： G01N33/00
CPC分类号： B01L3/502715 , B01L3/502723 , B01L2200/0684 , B01L2300/0645 , B01L2300/0816 , B01L2300/0825 , B01L2300/0861 , B01L2300/0887 , B01L2400/0406 , G01N27/3272
摘要： A sensor for analyzing a fluid sample has a sample cavity for accepting sample fluid. At least one test region is disposed along the sample cavity, and at least one vent fulfills the dual function of venting the sample cavity and guiding the sample fluid in the sample cavity via appropriate location and geometry of at least one sample guide edge.
摘要翻译： 用于分析流体样品的传感器具有用于接收样品流体的样品腔。 沿着样品腔设置至少一个测试区域，并且至少一个排气口满足通过样品空腔的双重功能，并通过至少一个样品引导边缘的适当位置和几何形状来引导样品腔中的样品流体。
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公开(公告)号：US07945394B2
公开(公告)日：2011-05-17
申请号：US11597579
申请日：2005-06-16
IPC分类号： G01F23/00
CPC分类号： G01N27/3274
摘要： A method of detecting incomplete filling of an electrochemical biosensor by collecting a series of electrical current values when a constant electrical potential is applied across the working and counter electrodes during a preliminary burn period. The slope of a line determined by linear regression based on the series of current values is used to determine whether or not the biosensor is incompletely filled. If the line has a positive slope, the biosensor is reported to be under filled. If the slope is not positive, the correlation coefficient of the current values is used as a supplemental test to indicate whether or not the biosensor is incompletely filled.
摘要翻译： 一种通过在预备燃烧期间在工作电极和对电极上施加恒定电位时收集一系列电流值来检测电化学生物传感器的不完全填充的方法。 使用基于一系列当前值的线性回归确定的线的斜率来确定生物传感器是否不完全填充。 如果线路呈正斜率，则报告生物传感器处于充满状态。 如果斜率不正，则使用当前值的相关系数作为补充测试，以指示生物传感器是否未完全填充。
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公开(公告)号：US20080033667A1
公开(公告)日：2008-02-07
申请号：US11597579
申请日：2005-06-16
申请人： Daniel Brown , Christina Blaschke
发明人： Daniel Brown , Christina Blaschke
IPC分类号： G01F23/00
CPC分类号： G01N27/3274
摘要： A method of detecting incomplete filling of an electrochemical biosensor by collecting a series of electrical current values when a constant electrical potential is applied across the working and counter electrodes during a preliminary burn period. The slope of a line determined by linear regression based on the series of current values is used to determine whether or not the biosensor is incompletely filled. If the line has a positive slope, the biosensor is reported to be under filled. If the slope is not positive, the correlation coefficient of the current values is used as a supplemental test to indicate whether or not the biosensor is incompletely filled.
摘要翻译： 一种通过在预备燃烧期间在工作电极和对电极上施加恒定电位时收集一系列电流值来检测电化学生物传感器的不完全填充的方法。 使用基于一系列当前值的线性回归确定的线的斜率来确定生物传感器是否不完全填充。 如果线路呈正斜率，则报告生物传感器处于充满状态。 如果斜率不正，则使用当前值的相关系数作为补充测试，以指示生物传感器是否未完全填充。
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公开(公告)号：US08007656B2
公开(公告)日：2011-08-30
申请号：US10576485
申请日：2004-10-22
申请人： Huan-Ping Wu , Greg P. Beer , Christina Blaschke
发明人： Huan-Ping Wu , Greg P. Beer , Christina Blaschke
IPC分类号： G01N27/416 , G01N27/327
摘要： An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.
摘要翻译： 电化学传感器条带具有基底和基底上的第一电极和第二电极。 氧化还原酶和介体位于第一电极上，可溶性氧化还原物质位于第二电极上。 可溶性氧化还原物质可以是有机过渡金属络合物，过渡金属配位络合物，电活性有机分子或其混合物。
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公开(公告)号：US20070080073A1
公开(公告)日：2007-04-12
申请号：US10576485
申请日：2004-10-22
申请人： Huang-Ping Wu , Greg Beer , Christina Blaschke
发明人： Huang-Ping Wu , Greg Beer , Christina Blaschke
IPC分类号： C12Q1/00 , G01N33/487
摘要： An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.
摘要翻译： 电化学传感器条带具有基底和基底上的第一电极和第二电极。 氧化还原酶和介体位于第一电极上，可溶性氧化还原物质位于第二电极上。 可溶性氧化还原物质可以是有机过渡金属络合物，过渡金属配位络合物，电活性有机分子或其混合物。
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公开(公告)号：US20120037514A1
公开(公告)日：2012-02-16
申请号：US13214643
申请日：2011-08-22
申请人： Huan-Ping Wu , Greg P. Beer , Christina Blaschke
发明人： Huan-Ping Wu , Greg P. Beer , Christina Blaschke
IPC分类号： G01N27/327 , G01N33/50
摘要： An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.
摘要翻译： 电化学传感器条带具有基底和基底上的第一电极和第二电极。 氧化还原酶和介体位于第一电极上，可溶性氧化还原物质位于第二电极上。 可溶性氧化还原物质可以是有机过渡金属络合物，过渡金属配位络合物，电活性有机分子或其混合物。
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8.发明授权Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes 有权用于检测分析物的试剂和方法，以及包含用于检测分析物的试剂的装置公开(公告)号：US07163616B2
公开(公告)日：2007-01-16
申请号：US10231539
申请日：2002-09-03
申请人： Mark S. Vreeke , Mary Ellen Warchal-Windham , Christina Blaschke , Barbara J. Mikel , Howard A. Cooper
发明人： Mark S. Vreeke , Mary Ellen Warchal-Windham , Christina Blaschke , Barbara J. Mikel , Howard A. Cooper
IPC分类号： G01N27/327
摘要： Reagents for detecting an analyte are described. A reagent comprises (a) an enzyme selected from the group consisting of a flavoprotein, a quinoprotein, and a combination thereof; and (b) a mediator selected from the group consisting of a phenothiazine, a phenoxazine, and a combination thereof. In addition, reagents having good stability to radiation sterilization are described. Electrochemical sensors and sampling devices comprising such reagents, methods of producing a sterilized device including such reagents, and methods for detecting an analyte which utilize such reagents are described as well.
摘要翻译： 描述了用于检测分析物的试剂。 试剂包含（a）选自由黄素蛋白，喹啉蛋白及其组合组成的组的酶; 和（b）选自吩噻嗪，吩恶嗪及其组合的介体。 另外还描述了对放射线灭菌具有良好稳定性的试剂。 还描述了包括这种试剂的电化学传感器和取样装置，包括这种试剂的灭菌装置的生产方法，以及利用这些试剂检测分析物的方法。
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公开(公告)号：US08691073B2
公开(公告)日：2014-04-08
申请号：US13214643
申请日：2011-08-22
申请人： Huan-Ping Wu , Greg P. Beer , Christina Blaschke
发明人： Huan-Ping Wu , Greg P. Beer , Christina Blaschke
IPC分类号： G01N27/416 , G01N27/327
摘要： An electrochemical sensor strip has a base and a first electrode and a second electrode on the base. An oxidoreductase enzyme and a mediator are on the first electrode, and a soluble redox species is on the second electrode. The soluble redox species may be an organotransition metal complex, a transition metal coordination complex, an electroactive organic molecule, or mixtures thereof.
摘要翻译： 电化学传感器条带具有基底和基底上的第一电极和第二电极。 氧化还原酶和介体位于第一电极上，可溶性氧化还原物质位于第二电极上。 可溶性氧化还原物质可以是有机过渡金属络合物，过渡金属配位络合物，电活性有机分子或其混合物。
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