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    Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes
    1.
    发明授权
    Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes 有权
    用于检测分析物的试剂和方法，以及包含用于检测分析物的试剂的装置

    公开(公告)号：US07163616B2

    公开(公告)日：2007-01-16

    申请号：US10231539

    申请日：2002-09-03

    申请人： Mark S. Vreeke ,  Mary Ellen Warchal-Windham ,  Christina Blaschke ,  Barbara J. Mikel ,  Howard A. Cooper

    发明人： Mark S. Vreeke ,  Mary Ellen Warchal-Windham ,  Christina Blaschke ,  Barbara J. Mikel ,  Howard A. Cooper

    IPC分类号： G01N27/327

    CPC分类号： C12Q1/54 ,  C12Q1/32

    摘要： Reagents for detecting an analyte are described. A reagent comprises (a) an enzyme selected from the group consisting of a flavoprotein, a quinoprotein, and a combination thereof; and (b) a mediator selected from the group consisting of a phenothiazine, a phenoxazine, and a combination thereof. In addition, reagents having good stability to radiation sterilization are described. Electrochemical sensors and sampling devices comprising such reagents, methods of producing a sterilized device including such reagents, and methods for detecting an analyte which utilize such reagents are described as well.

    摘要翻译： 描述了用于检测分析物的试剂。 试剂包含（a）选自由黄素蛋白，喹啉蛋白及其组合组成的组的酶; 和（b）选自吩噻嗪，吩恶嗪及其组合的介体。 另外还描述了对放射线灭菌具有良好稳定性的试剂。 还描述了包括这种试剂的电化学传感器和取样装置，包括这种试剂的灭菌装置的生产方法，以及利用这些试剂检测分析物的方法。

    Use of CO.sub.2 absorbant for stabilization of dried alkaline reagent in creatinine assay
    2.
    发明授权
    Use of CO.sub.2 absorbant for stabilization of dried alkaline reagent in creatinine assay 失效
    在肌酐测定中使用CO2吸收剂来稳定干燥的碱性试剂

    公开(公告)号：US5610073A

    公开(公告)日：1997-03-11

    申请号：US534267

    申请日：1995-09-26

    申请人： Amy H. Chu ,  Wei-Sen Chu ,  Howard A. Cooper

    发明人： Amy H. Chu ,  Wei-Sen Chu ,  Howard A. Cooper

    IPC分类号： G01N31/22 ,  C07C205/57 ,  G01N33/52 ,  G01N33/70 ,  G01N33/00

    CPC分类号： G01N33/70 ,  Y10T436/147777 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/255

    摘要： Disclosed is an improvement to the method for the detection of creatinine in which creatinine, in aqueous solution, is contacted with a dry reagent system of an indicator for creatinine. The assay is carried out at a pH above about 11.5 which is maintained by an alkaline material. The improvement involves packaging the reagent system with a material capable of absorbing CO.sub.2 and at least some ambient water vapor. This inhibits the formation of carbonic acid thereby reducing the neutralization of the alkaline reagent system during storage to increase the shelf life and decrease the variability of the system.

    摘要翻译： 公开了对肌酸酐检测方法的改进，其中肌酸酐在水溶液中与肌酸酐指示剂的干试剂体系接触。 该测定在高于约11.5的pH下进行，其由碱性材料维持。 该改进涉及用能够吸收CO 2和至少一些环境水蒸汽的材料包装试剂系统。 这抑制了碳酸的形成，从而减少了储存期间碱性试剂体系的中和，从而提高了保质期并降低了系统的变异性。