公开(公告)号：US20090111767A1

公开(公告)日：2009-04-30

申请号：US12187362

申请日：2008-08-06

申请人： Christoper J. WRAIGHT ,  George A. Werther ,  Nicholas M. Dean ,  Kenneth J. Dobie

发明人： Christoper J. WRAIGHT ,  George A. Werther ,  Nicholas M. Dean ,  Kenneth J. Dobie

IPC分类号： A61K31/7088 ,  C07H21/00 ,  C12Q1/68 ,  A61P17/06

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/72 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12N2310/3525

摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.

摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。