公开(公告)号：US09586058B2

公开(公告)日：2017-03-07

申请号：US13125888

申请日：2009-10-17

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1043 ,  A61N2005/1087

摘要： The idea concerns irradiation of a target volume (53), wherein intensities for target points (70) are determined which are sequentially approached by a beam, comprising the following steps: detecting a volume (63) to be protected, wherein a dose generated by irradiating a target volume (53) does not exceed a predetermined maximum value; determining intensities for target points (70) in such a way that within the volume (63) to be protected the generated dose does not exceed the predetermined maximum value, wherein a dose contribution data record is used for determining the intensities, which dose contribution data record comprises the dose generated at other spots (73) by directing the beam (10) on one of the target points (70) with a predetermined intensity.

摘要翻译： 该想法涉及目标体积（53）的照射，其中确定由光束顺序逼近的目标点（70）的强度，包括以下步骤：检测待保护的体积（63），其中由 照射目标体积（53）不超过预定的最大值; 以这样的方式确定目标点（70）的强度，使得在待保护的体积（63）内，所产生的剂量不超过预定的最大值，其中剂量贡献数据记录用于确定强度，哪个剂量贡献数据 记录包括通过以预定强度将光束（10）引导到其中一个目标点（70）上而在其它点（73）处产生的剂量。

公开(公告)号：US20100108903A1

公开(公告)日：2010-05-06

申请号：US12532590

申请日：2008-02-19

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： H01J3/14 ,  A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1061 ,  A61N2005/1087

摘要： Abstract: A control parameter is determined for a system (10) for irradiating a predetermined target volume in a body (77) with a particle beam (75). The system is constructed to direct the particle beam at a multiplicity of target points (30) in the target volume in succession in order to produce at, each of the target points a predetermined dose distribution (42) in a region around the target point. The control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighbouring target points. For determination of the control parameter, there is first determined (94) a movement parameter which quantitatively characterises the movement of the body at the first target point. The control parameter is determined (95) in dependence on the movement parameter.

摘要翻译： 摘要：确定用于用粒子束（75）照射体（77）中的预定目标体积的系统（10）的控制参数。 该系统构造成将粒子束连续地引导到目标体积中的多个目标点（30），以便在每个目标点处在目标点周围的区域中产生预定剂量分布（42）。 控制参数控制第一目标点的剂量分布与相邻目标点的剂量分布重叠的程度。 为了确定控制参数，首先确定（94）定量表征身体在第一目标点处的运动的运动参数。 控制参数根据移动参数确定（95）。

公开(公告)号：US20100074408A1

公开(公告)日：2010-03-25

申请号：US12532601

申请日：2008-03-19

申请人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel

发明人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N2005/1087

摘要： A system for irradiating a predetermined target volume in a body with a particle beam is constructed to direct the particle beam at a multiplicity of target points in the body in succession, in order to produce at each of the target points a predetermined dose distribution. For the system there is determined a planning target volume by first determining, in a fictive homogeneous body, a target volume equivalent to the minimum target volume in the body. The equivalent target volume is extended by a safety margin, in order to determine the planning target volume.

摘要翻译： 构造用于以粒子束照射身体中的预定目标体积的系统，以将粒子束连续地引导到身体中的多个目标点，以便在每个目标点处产生预定的剂量分布。 对于系统，通过首先在虚构的均匀体中确定与体内最小目标体积相当的目标体积来确定计划目标体积。 为了确定计划目标量，相当的目标体积以安全余地进行扩展。

公开(公告)号：US20090095921A1

公开(公告)日：2009-04-16

申请号：US12086940

申请日：2006-12-08

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： A61N5/00

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1087 ,  G21K1/10

摘要： There is proposed a device for the slice-by-slice irradiation of tumour tissue (3) in a patient using a particle beam, having—an accelerator (7) for generating a particle beam (5) with predetermined energy for each slice, —a raster scanning device (9), acting on the particle beam (5), for the slice-by-slice scanning of the tumour tissue (3), —a modulator (17) for modulating the energy of the particle beam (5), —a detection device (37) for the time-resolved detection of the position of the tumour tissue (3) and having—a first storage device for storing data relating to the tumour tissue (3), which were determined prior to the irradiation operation, and for releasing that data to the raster scanning device (9) and to the modulator (17). The device is characterised by—a module (39), which registers the data on the course of the irradiation and the data of the detection device (37) which have been obtained during an irradiation operation.

摘要翻译： 提出了一种用于使用粒子束对患者的肿瘤组织（3）进行逐片照射的装置，该装置具有用于为每个切片生成具有预定能量的粒子束（5）的加速器（7） 作用于粒子束（5）的光栅扫描装置（9），用于肿瘤组织（3）的逐片扫描;调制器（17），用于调制粒子束（5）的能量; - 用于时间分辨检测肿瘤组织（3）的位置的检测装置（37），并具有用于存储与照射前相关的肿瘤组织（3）的数据的第一存储装置 操作，并将该数据释放到光栅扫描装置（9）和调制器（17）。 该装置的特征在于模块（39），其在辐射过程中登记数据和在照射操作期间获得的检测装置（37）的数据。

公开(公告)号：US08299448B2

公开(公告)日：2012-10-30

申请号：US12532590

申请日：2008-02-19

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1061 ,  A61N2005/1087

摘要： A control parameter is determined for a system for irradiating a predetermined target volume in a body with a particle beam. The system is constructed to direct the particle beam at a multiplicity of target points in the target volume in succession in order to produce at, each of the target points a predetermined dose distribution in a region around the target point. The control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighboring target points. For determination of the control parameter, there is first determined a movement parameter which quantitatively characterizes the movement of the body at the first target point. The control parameter is determined in dependence on the movement parameter.

摘要翻译： 对于用于用粒子束照射身体中的预定目标体积的系统来确定控制参数。 该系统被构造成将粒子束连续地引导到目标体积中的多个目标点，以便在每个目标点处产生在目标点周围的区域中的预定剂量分布。 控制参数控制第一目标点的剂量分布与相邻目标点的剂量分布重叠的程度。 为了确定控制参数，首先确定运动参数，其定量地表征身体在第一目标点处的运动。 根据运动参数确定控制参数。

公开(公告)号：US08217373B2

公开(公告)日：2012-07-10

申请号：US12532601

申请日：2008-03-19

申请人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel

发明人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel

IPC分类号： A61N5/10 ,  A61B6/00

CPC分类号： A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N2005/1087

摘要： A system for irradiating a predetermined target volume in a body with a particle beam is constructed to direct the particle beam at a multiplicity of target points in the body in succession, in order to produce at each of the target points a predetermined dose distribution. For the system there is determined a planning target volume by first determining, in a fictive homogeneous body, a target volume equivalent to the minimum target volume in the body. The equivalent target volume is extended by a safety margin, in order to determine the planning target volume.

摘要翻译： 构造用于以粒子束照射身体中的预定目标体积的系统，以将粒子束连续地引导到身体中的多个目标点，以便在每个目标点处产生预定的剂量分布。 对于系统，通过首先在虚构的均匀体中确定与体内最小目标体积相当的目标体积来确定计划目标体积。 为了确定计划目标量，相当的目标体积以安全余地进行扩展。

公开(公告)号：US07928415B2

公开(公告)日：2011-04-19

申请号：US12086940

申请日：2006-12-08

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： A61N5/00

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1087 ,  G21K1/10

摘要： There is proposed a device for the slice-by-slice irradiation of tumour tissue (3) in a patient using a particle beam, having—an accelerator (7) for generating a particle beam (5) with predetermined energy for each slice, —a raster scanning device (9), acting on the particle beam (5), for the slice-by-slice scanning of the tumour tissue (3), —a modulator (17) for modulating the energy of the particle beam (5), —a detection device (37) for the time-resolved detection of the position of the tumour tissue (3) and having—a first storage device for storing data relating to the tumour tissue (3), which were determined prior to the irradiation operation, and for releasing that data to the raster scanning device (9) and to the modulator (17). The device is characterized by—a module (39), which registers the data on the course of the irradiation and the data of the detection device (37) which have been obtained during an irradiation operation.

摘要翻译： 提出了一种用于使用粒子束对患者的肿瘤组织（3）进行逐片照射的装置，该装置具有用于为每个切片生成具有预定能量的粒子束（5）的加速器（7） 作用于粒子束（5）的光栅扫描装置（9），用于肿瘤组织（3）的逐片扫描;调制器（17），用于调制粒子束（5）的能量; - 用于时间分辨检测肿瘤组织（3）的位置的检测装置（37），并具有用于存储与照射前相关的肿瘤组织（3）的数据的第一存储装置 操作，并将该数据释放到光栅扫描装置（9）和调制器（17）。 该装置的特征在于模块（39），其在辐射过程中登记数据和在照射操作期间获得的检测装置（37）的数据。

公开(公告)号：US08405050B2

公开(公告)日：2013-03-26

申请号：US12678562

申请日：2008-09-25

申请人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel ,  Alexander Gemmel

发明人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel ,  Alexander Gemmel

IPC分类号： G01J1/00

CPC分类号： A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1061 ,  A61N2005/1072 ,  A61N2005/1087

摘要： A method of determining an actual, especially an actual effective, radiation dose distribution of a moving target volume includes detecting first and further positions of volume elements of the target volume in a first and at least one further motional state of the moving target volume, determining transformation parameters by transformation of the first positions into the further positions, irradiating the moving target volume in accordance with an irradiation plan which comprises a plurality of raster points to be irradiated, wherein during the irradiation of a raster point it is detected which of the motional states is occupied by the moving target volume, assigning raster points to subirradiation plans and determining the actual effective dose for each of the plurality of volume elements, in each case from contributions from the raster points of the subirradiation plans using the transformation parameters. Calculation and application of correction parameters which compensate for changes, caused by movement, to the position of the Bragg maximum and to the biologically effective dose applied.

摘要翻译： 确定移动目标体积的实际的，特别是实际有效的辐射剂量分布的方法包括：检测目标体积的体积元素在移动目标体积的第一和至少一个另外的运动状态中的第一和另外的位置，确定 通过将第一位置变换为其他位置，根据包括要照射的多个光栅点的照射方案照射移动目标体积，在光栅点的照射期间检测哪个运动目标体积， 状态由移动目标体积占据，将光栅点分配给子辐射计划，并且在每个情况下确定多个体积元素中的每一个的实际有效剂量，这取决于来自使用变换参数的子照射计划的光栅点的贡献。 校正参数的计算和应用，补偿由运动引起的布拉格最大位置和施加的生物有效剂量的变化。

公开(公告)号：US20100301235A1

公开(公告)日：2010-12-02

申请号：US12678562

申请日：2008-09-25

申请人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel ,  Alexander Gemmel

发明人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel ,  Alexander Gemmel

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1061 ,  A61N2005/1072 ,  A61N2005/1087

摘要： A method of determining an actual, especially an actual effective, radiation dose distribution of a moving target volume includes detecting first and further positions of volume elements of the target volume in a first and at least one further motional state of the moving target volume, determining transformation parameters by transformation of the first positions into the further positions, irradiating the moving target volume in accordance with an irradiation plan which comprises a plurality of raster points to be irradiated, wherein during the irradiation of a raster point it is detected which of the motional states is occupied by the moving target volume, assigning raster points to subirradiation plans and determining the actual effective dose for each of the plurality of volume elements, in each case from contributions from the raster points of the subirradiation plans using the transformation parameters. Calculation and application of correction parameters which compensate for changes, caused by movement, to the position of the Bragg maximum and to the biologically effective dose applied.

摘要翻译： 确定移动目标体积的实际的，特别是实际有效的辐射剂量分布的方法包括：检测目标体积的体积元素在移动目标体积的第一和至少一个另外的运动状态中的第一和另外的位置，确定 通过将第一位置变换为其他位置，根据包括要照射的多个光栅点的照射方案照射移动目标体积，在光栅点的照射期间检测哪个运动目标体积， 状态由移动目标体积占据，将光栅点分配给子辐射计划，并且在每个情况下确定多个体积元素中的每一个的实际有效剂量，这取决于来自使用变换参数的子照射计划的光栅点的贡献。 校正参数的计算和应用，补偿由运动引起的布拉格最大位置和施加的生物有效剂量的变化。

公开(公告)号：US09245657B2

公开(公告)日：2016-01-26

申请号：US14236453

申请日：2012-08-03

申请人： Nami Saito ,  Christoph Bert ,  Eike Rietzel

发明人： Nami Saito ,  Christoph Bert ,  Eike Rietzel

IPC分类号： A61N5/00 ,  G21K1/00 ,  A61N5/10 ,  G21K1/10

CPC分类号： G21K1/00 ,  A61N5/1043 ,  A61N5/1048 ,  A61N5/1075 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10

摘要： The present disclosure relates to a particle energy modulating device for variably changing the energy of the particles of a particle beam. The particle energy modulating device has a variable energy varying device with a control value correcting device for correcting a supplied control value. The control value correcting device corrects the supplied control values through the use of previously determined calibration data.

摘要翻译： 本公开涉及用于可变地改变粒子束的粒子的能量的粒子能量调节装置。 粒子能量调节装置具有可变能量变化装置，其具有用于校正所提供的控制值的控制值校正装置。 控制值校正装置通过使用先前确定的校准数据来校正提供的控制值。