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1.发明公开公开(公告)号：US20230340397A9
公开(公告)日：2023-10-26
申请号：US16579889
申请日：2019-09-24
Applicant: Christopher B. REID
Inventor： Christopher B. REID , Melissa BRAGA , Lilian N. SANTAMARIA , Ashley N. WICKREMA , Marinne D. WICKREMA , Anthony HAO DINH , Yaman EKSIOGLU , Mat HOANG HO
CPC classification number: C12M43/00 , C12M21/00 , C12N15/102 , C12N15/111 , C12M23/42 , C12M35/02
Abstract: The claimed invention is directed towards a novel combination cell electroporation/cell culturing apparatus which can be termed a cell culture dish suitable for in vitro electroporation, and towards a device suitable for in vivo electroporation—both useful in methods suitable for the generation of developmentally-activated, pluripotent, pluripotent-like, multipotent, and/or self-renewing cells which are capable of beginning to differentiate in culture into a variety of cell types and capable of further differentiation in vivo. The claimed invention is also directed towards the generation of desirable, differentiating somatic cell populations transplantable to animals or patients, genetic modification of endogenous and exogenous cells, and the treatment of patients suffering from diseases that may be ameliorated by these methods. This invention also provides methods for preventing, treating, or retarding disease, for example, immunodeficiency virus (e.g. HIV-1, HIV-2, SIV, FIV, etc.) infection.
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公开(公告)号：US20220298468A1
公开(公告)日：2022-09-22
申请号：US17763623
申请日：2020-09-24
Applicant: Christopher B REID , Melissa BRAGA , Lillian N SANTAMARIA , Ashley N WICKREMA , Marinne D WICKREMA , Anthony HAO DINH , Yaman EKSIOGLU , Mat HOANG HO
Inventor： Christopher B REID , Melissa BRAGA , Lillian N SANTAMARIA , Ashley N WICKREMA , Marinne D WICKREMA , Anthony HAO DINH , Yaman EKSIOGLU , Mat HOANG HO
Abstract: The claimed invention is directed towards equipment, methods and compositions involving application of an Electric field that are suitable for in vivo electroporation, in vitro application of an Electric field and the generation of developmentally-activated, totipotent, pluripotent, pluripotent-like, multipotent, and/or self-renewing cells which are capable of beginning to differentiate in culture into a variety of cell types and capable of further differentiation in vivo. The claimed invention is also directed towards the generation of desirable, differentiating somatic cell populations transplantable to animals or patients, to drug screening and drug discovery, cellular therapy, immunotherapy, gene therapy, tissue engineering, and the treatment of patients suffering from diseases that may be ameliorated by these methods. This invention also provides methods for preventing, treating, or retarding disease, for example, immunodeficiency virus (e.g. HIV-1, HIV-2, SIV, FIV, etc.) infection.
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3.发明申请公开(公告)号：US20200048600A1
公开(公告)日：2020-02-13
申请号：US16579889
申请日：2019-09-24
Applicant: Christopher B. REID
Inventor： Christopher B. REID , Melissa BRAGA , Lilian N. SANTAMARIA , Ashley N. WICKREMA , Marinne D. WICKREMA , Anthony HAO DINH , Yaman EKSIOGLU , Mat HOANG HO
Abstract: The claimed invention is directed towards a novel combination cell electroporation/cell culturing apparatus which can be termed a cell culture dish suitable for in vitro electroporation, and towards a device suitable for in vivo electroporation—both useful in methods suitable for the generation of developmentally-activated, pluripotent, pluripotent-like, multipotent, and/or self-renewing cells which are capable of beginning to differentiate in culture into a variety of cell types and capable of further differentiation in vivo. The claimed invention is also directed towards the generation of desirable, differentiating somatic cell populations transplantable to animals or patients, genetic modification of endogenous and exogenous cells, and the treatment of patients suffering from diseases that may be ameliorated by these methods. This invention also provides methods for preventing, treating, or retarding disease, for example, immunodeficiency virus (e.g. HIV-1, HIV-2, SIV, FIV, etc.) infection.
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