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    Nucleotide, deduced amino acid sequence, isolation and purification of heat-shock chlamydial proteins
    2.
    发明授权
    Nucleotide, deduced amino acid sequence, isolation and purification of heat-shock chlamydial proteins 失效
    核苷酸，推测的氨基酸序列，热休克衣原体蛋白的分离和纯化

    公开(公告)号：US5071962A

    公开(公告)日：1991-12-10

    申请号：US531317

    申请日：1990-05-31

    申请人： Richard P. Morrison ,  Harlan D. Caldwell

    发明人： Richard P. Morrison ,  Harlan D. Caldwell

    IPC分类号： A61K38/00 ,  C07K14/295 ,  C07K16/12 ,  C12N15/31

    CPC分类号： C07K14/295 ,  C07K16/125 ,  A61K38/00 ,  Y10S530/808 ,  Y10S530/809

    摘要： The present invention relates to novel polypeptides comprising a unique "chlamydial-specific" primary structural conformation and one or more of the biological properties of eukaryotic or prokaryotic stress-response proteins which are characterized by being the expressed products of an endogenous or exogenous DNA sequence in a eukaryotic or prokaryotic host cell. Sequences coding for part or all of the amino acid residues of the chlamydial HypA or HypB protein or for analogs thereof may be incorporated into autonomously replicating vectors employed to transform or transfect suitable procaryotic or eukaryotic host cells such as bacteria or vertebrate cells in culture. The HypB protein is a member of the family of stress response proteins referred to as HSP60. Products of expression of the DNA sequences display the identical physical, immunological, and histological properties as the chlamydial proteins isolated from natural, non-recombinant, organisms.

    摘要翻译： 本发明涉及包含独特的“衣原体特异性”初级结构构象和一种或多种真核或原核应激蛋白的生物学特性的新型多肽，其特征在于内源或外源DNA序列的表达产物 真核或原核宿主细胞。 编码衣原体HypA或HypB蛋白的部分或全部氨基酸残基或其类似物的序列可以并入到用于转化或转染合适的原核或真核宿主细胞如培养物中的细菌或脊椎动物细胞的自主复制载体中。 HypB蛋白是称为HSP60的应激反应蛋白家族的成员。 DNA序列的表达产物显示与从天然非重组生物分离的衣原体蛋白质相同的物理，免疫学和组织学性质。

    Nucleotide deduced amino acid sequence, isolation and purification of heat-shock chlamydial proteins
    3.
    发明授权
    Nucleotide deduced amino acid sequence, isolation and purification of heat-shock chlamydial proteins 失效
    核苷酸推测氨基酸序列，分离和纯化热休克衣原体蛋白

    公开(公告)号：US06423835B1

    公开(公告)日：2002-07-23

    申请号：US09071506

    申请日：1998-05-01

    申请人： Richard P. Morrison ,  Harlan D. Caldwell

    发明人： Richard P. Morrison ,  Harlan D. Caldwell

    IPC分类号： C07H2104

    CPC分类号： C07K14/295 ,  A61K38/00 ,  C07K16/125 ,  Y10S530/808 ,  Y10S530/809

    摘要： The present invention relates to novel polypeptides comprising a unique “chlamydial-specific” primary structural conformation and one or more of the biological properties of eukaryotic or prokaryotic stress-response proteins which are characterized by being the expressed products of an endogenous or exogenous DNA sequence in a eukaryotic or prokaryotic host cell. Sequences coding for part or all of the amino acid residues of the chlamydial HypA or HypB protein or for analogs thereof may be incorporated into autonomously replicating vectors employed to transform or transfect suitable procaryotic or eukaryotic host cells such as bacteria or vertebrate cells in culture. The HypB protein is a member of the family of stress response proteins referred to as HSP60. Products of expression of the DNA sequences display the identical physical, immunological, and histological properties as the chlamydial proteins isolated from natural, non-recombinant, organisms.

    摘要翻译： 本发明涉及包含独特的“衣原体特异性”初级结构构象和一种或多种真核或原核应激蛋白的生物学特性的新型多肽，其特征在于内源或外源DNA序列的表达产物 真核或原核宿主细胞。 编码衣原体HypA或HypB蛋白的部分或全部氨基酸残基或其类似物的序列可以并入到用于转化或转染合适的原核或真核宿主细胞如培养物中的细菌或脊椎动物细胞的自主复制载体中。 HypB蛋白是称为HSP60的应激反应蛋白家族的成员。 DNA序列的表达产物显示与从天然非重组生物分离的衣原体蛋白质相同的物理，免疫学和组织学性质。