公开(公告)号：US20120190695A1

公开(公告)日：2012-07-26

申请号：US13439511

申请日：2012-04-04

申请人： Christopher L. VANDEUSEN ,  Franz J. WEIBERTH ,  Harpal S. GILL ,  George LEE ,  Andrea HILLEGASS

发明人： Christopher L. VANDEUSEN ,  Franz J. WEIBERTH ,  Harpal S. GILL ,  George LEE ,  Andrea HILLEGASS

IPC分类号： A61K31/506 ,  A61P37/08 ,  A61P29/00 ,  A61P11/06 ,  A61P27/02 ,  A61P11/00 ,  C07C259/18 ,  C07D271/06 ,  C07D401/14 ,  C07D413/14 ,  A61P11/02

CPC分类号： A61K31/506 ,  C07D217/06 ,  C07D271/06 ,  C07D413/14

摘要： This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).

摘要翻译： 本发明涉及式（I）化合物：其中R1，R2和R3如本文所定义，药物组合物包含化合物，中间体和制备所述化合物的方法，以及该化合物用于治疗过敏和/ 特别是诸如过敏性鼻炎，哮喘，慢性阻塞性肺病（COPD）和年龄相关性黄斑变性（AMD）的疾病。

公开(公告)号：US20110233439A1

公开(公告)日：2011-09-29

申请号：US12732354

申请日：2010-03-26

申请人： George LEE

发明人： George LEE

IPC分类号： F16K1/00

CPC分类号： F16K31/60 ,  F16K35/027

摘要： A control head includes a valve seat, a shaft module, an elastic member and a cap. The valve seat includes a shaft tube, and interconnected intake tube and discharge tube extended separately from the shaft tube. The shaft module having an end passed inside the shaft tube includes a moving rod, a conical piston sheathed onto a lower end of the moving rod, and an oblique surface formed separately at internal ends of the intake and discharge tubes and corresponding to an oblique surface of the conical piston. Both ends of the elastic member contained inside the shaft tube are pressed against the valve seat and the shaft module, and a cap is covered onto the valve seat, and another end of the shaft module is passed out of the cap and coupled to a press button, such that the control head can provide smooth downward pressing and resuming movements.

摘要翻译： 控制头包括阀座，轴模块，弹性构件和盖。 阀座包括轴管，并且与轴管分开延伸的互连的进气管和排出管。 具有穿过轴管内的端部的轴组件包括移动杆，套在活动杆的下端上的锥形活塞，以及分别形成在进排气管的内端处并对应于倾斜表面的倾斜表面 的锥形活塞。 包含在轴管内部的弹性构件的两端被压靠在阀座和轴模块上，并且帽被覆盖在阀座上，并且轴组件的另一端从帽中通过并联接到压力机 按钮，使得控制头可以提供平稳的向下按压和恢复运动。