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    Clonidine formulation in a polyorthoester carrier
    1.
    发明授权
    Clonidine formulation in a polyorthoester carrier 有权
    聚异丁酸酯载体中的可乐定制剂

    公开(公告)号：US09132119B2

    公开(公告)日：2015-09-15

    申请号：US12412024

    申请日：2009-03-26

    申请人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    发明人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    IPC分类号： A61F2/00 ,  A61K31/415 ,  A61K9/00 ,  A61K9/16 ,  A61K9/06

    CPC分类号： A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

    Clonidine Formulation in a Polyorthoester Carrier
    2.
    发明申请
    Clonidine Formulation in a Polyorthoester Carrier 有权
    多聚酯载体中的可乐定配方

    公开(公告)号：US20090263448A1

    公开(公告)日：2009-10-22

    申请号：US12412024

    申请日：2009-03-26

    申请人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    发明人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    IPC分类号： A61K9/00

    CPC分类号： A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。