公开(公告)号：US20110039847A1

公开(公告)日：2011-02-17

申请号：US12740686

申请日：2008-10-31

申请人： Christopher Oalmann ,  Robert B. Perni ,  Jeremy S. Disch ,  Bruce Szczepankiewicz ,  Giovanna Gualtieri ,  Rebecca L. Casaubon ,  Karsten J. Koppetsch

发明人： Christopher Oalmann ,  Robert B. Perni ,  Jeremy S. Disch ,  Bruce Szczepankiewicz ,  Giovanna Gualtieri ,  Rebecca L. Casaubon ,  Karsten J. Koppetsch

IPC分类号： A61K31/5377 ,  C07D239/42 ,  C07D401/12 ,  C07D403/04 ,  C07D413/14 ,  A61K31/497 ,  A61P3/00 ,  A61P3/10

CPC分类号： C07D239/42 ,  C07D213/81 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了由结构式（I）表示的新型沉默调节蛋白的调节性化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

公开(公告)号：US20110009381A1

公开(公告)日：2011-01-13

申请号：US12742067

申请日：2008-11-07

申请人： Chi B. Vu ,  Christopher Oalmann ,  Robert B. Perni ,  Jeremy S. Disch ,  Bruce Szczepankiewicz ,  Giovanna Gualtieri ,  Rebecca L. Casaubon

发明人： Chi B. Vu ,  Christopher Oalmann ,  Robert B. Perni ,  Jeremy S. Disch ,  Bruce Szczepankiewicz ,  Giovanna Gualtieri ,  Rebecca L. Casaubon

IPC分类号： C07D513/04 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/4365 ,  A61K31/541 ,  A61K31/506 ,  A61K31/551 ,  A61P3/10 ,  A61P3/00

CPC分类号： C07D513/04 ,  C07D519/00

摘要： Provided herein are novel sirtuin-modulating compounds Structural Formula (I): and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

摘要翻译： 本文提供了新的沉默调节蛋白的调节性化合物结构式（I）及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防多种疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。