摘要:
The invention relates to methods and compositions for reducing serum levels of triacylglycerides in human subjects. In particular, the invention relates to the oral administration of an effective amount of a fungal lipase formulation, to a human subject having borderline-high or high serum levels of triacylglycerides, for a time period sufficient to reduce serum triacylglyceride levels.
摘要:
The invention relates to methods and compositions for reducing serum levels of triacylglycerides in human subjects. In particular, the invention relates to the oral administration of an effective amount of a fungal lipase formulation, to a human subject having borderline-high or high serum levels of triacylglycerides, for a time period sufficient to reduce serum triacylglyceride levels.
摘要:
An exercise suit which includes a resilient band extending through a guide pocket in a first direction along a pant leg or sleeve of the suit. The band engages a direction changing means near the end of the leg or sleeve and at least a portion of the band extends there beyond in a second direction. A free end of the band is releasably engaged with a tension adjustment mechanism provided on the exterior of the leg or sleeve a distance away from the direction changing means. The wearer adjusts the tension in the band by moving a length of the band through the direction changing means and repositioning the free end on the tension adjustment mechanism. A cover is removably disposed over the tension adjustment mechanism to prevent accidental dislodgement of the free end of the band.
摘要:
An exercise suit which includes a resilient band extending through a guide pocket in a first direction along a pant leg or sleeve of the suit. The band engages a direction changing means near the end of the leg or sleeve and at least a portion of the band extends there beyond in a second direction. A free end of the band is releasably engaged with a tension adjustment mechanism provided on the exterior of the leg or sleeve a distance away from the direction changing means. The wearer adjusts the tension in the band by moving a length of the band through the direction changing means and repositioning the free end on the tension adjustment mechanism. A cover is removably disposed over the tension adjustment mechanism to prevent accidental dislodgement of the free end of the band.
摘要:
The present invention is directed to the creation of human equivalent CDRs and antibodies containing them by a method of producing an antibody which specifically binds to an antigen.
摘要:
Adiponectin variants comprising one or more amino acid modifications to corresponding wild-type adiponectins at positions having predetermined hydrophobicity, predetermined polarity, predetermined electrostatic potential, Met, aromatic amino acid, Cys corresponding to position 152 of SEQ ID NO:1, amino acid affecting isoelectric point of the wild-type or variant adiponectin, amino acid affecting beta sheet formation, helix capping, or dipole interactions, or a combination thereof, wherein the adiponectin variants exhibit improved stability, solubility or soluble expression, expression yield, the ability to induce phosphorylation of AMPK, or a combination thereof, as compared to the corresponding wild-type adiponectins.
摘要翻译:在具有预定疏水性,预定极性,预定静电位,Met,芳香族氨基酸,对应于SEQ ID NO:1的位置152的Cys,影响等电点的氨基酸的位置,包含与相应的野生型脂连蛋白的一个或多个氨基酸修饰的脂连蛋白变体 野生型或变体脂联素的点,影响β片形成的氨基酸,螺旋封端或偶极相互作用或其组合,其中脂联素变体表现出改善的稳定性,溶解性或可溶性表达,表达产量,诱导磷酸化的能力 的AMPK,或其组合,与相应的野生型脂连蛋白相比。
摘要:
Variant antibodies and Fc fusion proteins with reduced immunogenicity are described. In particular, the variants of antibodies and Fc fusion proteins have reduced ability to bind one or more human class II MHC molecules are described.
摘要:
Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC protein is provided. A first component including at least one candidate peptides and a second component including at least one MHC protein are contacted. One of the components is immobilized on a solid support. The presence, absence, or quantity of binding of the peptide and said MHC protein is then determined.
摘要:
A method for recycling rail is provided wherein the rail is heated, and then slit into two pieces. The two pieces are passed through a single mill pass line such that each piece of the rail is deformed to have a generally uniform shape.
摘要:
The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an NKG2D antigen binding domain Fc fusion proteins.