公开(公告)号：US20060234239A1

公开(公告)日：2006-10-19

申请号：US10545354

申请日：2004-02-11

申请人： Christopher Wraight ,  George Werther ,  Nicholas Dean ,  Michael Dobie

发明人： Christopher Wraight ,  George Werther ,  Nicholas Dean ,  Michael Dobie

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/02

CPC分类号： C07H21/04 ,  A61K38/00 ,  C07H21/00 ,  C07H21/02 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y10T436/143333 ,  C12N2310/3525

摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.

摘要翻译： 本发明提供调节生长因子基因表达的组合物和方法。 特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。 这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。 然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。

公开(公告)号：US20050261230A1

公开(公告)日：2005-11-24

申请号：US11090351

申请日：2005-03-24

申请人： Christopher Wraight ,  George Werther ,  Stephanie Edmondson

发明人： Christopher Wraight ,  George Werther ,  Stephanie Edmondson

IPC分类号： A61K38/00 ,  C12N15/113 ,  A61K48/00

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/315 ,  C12N2310/335

摘要： The present invention relates generally to a method for the prophylaxis and/or treatment of skin disorders, and in particular proliferative and/or inflammatory skin disorders, and to genetic molecules useful for same. The present invention is particularly directed to genetic molecules capable of modulating growth factor interaction with its receptor on epidermal keratinocytes to inhibit, reduce or otherwise decrease stimulation of this layer of cells. The present invention contemplates, in a most preferred embodiment, a method for the prophylaxis and/or treatment of psoriasis.

摘要翻译： 本发明一般涉及用于预防和/或治疗皮肤病症，特别是增殖性和/或炎症性皮肤疾病以及对其有用的遗传分子的方法。 本发明特别涉及能够调节与其表皮角质形成细胞上的受体的生长因子相互作用以抑制，减少或以其它方式减少对该细胞层的刺激的遗传分子。 本发明在最优选的实施方案中考虑了预防和/或治疗牛皮癣的方法。