公开(公告)号：US06299666B1

公开(公告)日：2001-10-09

申请号：US09647174

申请日：2000-09-27

申请人： Christos Apostolidis ,  Willem Janssens ,  Lothar Koch ,  John McGinley ,  Roger Molinet ,  Michel Ougier ,  Jacques van Geel ,  Josef Möllenbeck ,  Hermann Schweickert

发明人： Christos Apostolidis ,  Willem Janssens ,  Lothar Koch ,  John McGinley ,  Roger Molinet ,  Michel Ougier ,  Jacques van Geel ,  Josef Möllenbeck ,  Hermann Schweickert

IPC分类号： C22B6002

CPC分类号： G21G1/10 ,  H05H6/00

摘要： This invention refers to a method for producing Actinium-225, comprising the steps of preparing a target (1) containing Radium-226, of irradiating this target with protons in a cyclotron and of chemically separating Actinium from the irradiated target material thereafter. According to the invention the proton energy in the cyclotron is adjusted such that the energy incident on the Ra-226 is between 10 and 20 MeV, preferably between 9 14 and 17 MeV. By this means the yield of production of the desired isotope Ac-225 is enhanced with respect to other radioisotopes.

摘要翻译： 本发明涉及一种制备锕-225的方法，包括以下步骤：制备含有镭-226的靶（1），用回旋加速器中的质子照射该靶，然后在其后化学分离锕。 根据本发明，调整回旋加速器中的质子能量，使得入射在Ra-226上的能量在10MeV之间，优选在914和17MeV之间。 通过这种方式，相对于其它放射性同位素，所需同位素Ac-225的产量提高。

公开(公告)号：US06485695B1

公开(公告)日：2002-11-26

申请号：US09530670

申请日：2000-05-04

申请人： Lothar Koch ,  Christos Apostolidis ,  Roger Molinet ,  Bruno Brandalise ,  Willem Janssens ,  Jacques Van Geel

发明人： Lothar Koch ,  Christos Apostolidis ,  Roger Molinet ,  Bruno Brandalise ,  Willem Janssens ,  Jacques Van Geel

IPC分类号： C22B3000

CPC分类号： G21G4/08

摘要： This invention relates to a method and an apparatus for preparing Bi-213 to be integrated in a radioimmunocojugate for human therapeutic use. According to the invention the method comprises the sequence of steps as follows: a) an ampoule 5 containing colloid-free actinium-225, obtained from drying an actinium nitrate solution, is loaded into a container 20 provided with radiation panels 21; b) a dissolving medium is poured into the ampoule 5; c) the solution obtained in the ampoule is transferred into an ion exchange column 6; d) an elution medium is circulated through the column 6; e) the eluate containing eluted Bi-213 is pumped towards a vial 10 for quantification and quality control.

摘要翻译： 本发明涉及一种用于制备Bi-213的方法和装置，以集成在用于人类治疗用途的放射免疫缀合物中。 根据本发明，该方法包括如下步骤：a）将含有无胶体的锕-225的安瓿5装载到设置有辐射面板21的容器20中，该安瓿5从干燥硝酸硝酸溶液获得。 b）将溶解介质倒入安瓿5中; c）将安瓿中得到的溶液转移到离子交换塔6中; d）洗脱介质循环通过柱6; e）将含有洗脱的Bi-213的洗脱液泵送到小瓶10用于定量和质量控制。

公开(公告)号：US20050008553A1

公开(公告)日：2005-01-13

申请号：US10847995

申请日：2004-05-19

申请人： Christos Apostolidis ,  Bruno Brandalise ,  Ramon Carlos-Marquez ,  Willem Janssens ,  Roger Molinet ,  Tuomo Nikula

发明人： Christos Apostolidis ,  Bruno Brandalise ,  Ramon Carlos-Marquez ,  Willem Janssens ,  Roger Molinet ,  Tuomo Nikula

IPC分类号： A61K51/02 ,  A61K51/06 ,  A61K51/12 ,  G21G4/08 ,  G21G4/00

CPC分类号： G21G4/08 ,  A61K51/02 ,  A61K51/06 ,  A61K51/1282

摘要： The invention relates to a method of loading a mother radionuclide into a radionuclide generator which comprises an cation exchange material, the said method comprising a preliminary step which consists in passing over said material a solution containing the mother radionuclide and a complexing agent for said radionuclide, said complexing agent being at an effective concentration so as to prevent the mother radionuclide from concentrating solely in one part of the volume of the cation exchange material, the cation exchange material being chosen in the group consisting of the macroporous resins and the resins having a crosslinking rate of from 1 to 12%. This method is applied to radioisotope generators which emit α particles and are used in particular in the field of radiotherapy.

摘要翻译： 本发明涉及一种将母体放射性核素装载到包含阳离子交换材料的放射性核素发生器中的方法，所述方法包括一个预备步骤，其中包括将含有母体放射性核素和所述放射性核素的络合剂的溶液通过所述材料， 所述络合剂处于有效浓度，以防止母体放射性核素仅在阳离子交换材料体积的一部分中浓缩，阳离子交换材料选自大孔树脂和具有交联性的树脂 率从1％到12％。 该方法适用于放射α粒子并特别用于放射治疗领域的放射性同位素发生器。

公开(公告)号：US20060198772A1

公开(公告)日：2006-09-07

申请号：US10548608

申请日：2004-03-05

申请人： Kamel Abbas ,  Christos Apostolidis ,  Willem Janssens ,  Hermann Stamm ,  Tuomo Nikula ,  Ramon Carlos-Marquez

发明人： Kamel Abbas ,  Christos Apostolidis ,  Willem Janssens ,  Hermann Stamm ,  Tuomo Nikula ,  Ramon Carlos-Marquez

IPC分类号： C01F13/00

CPC分类号： H05H6/00 ,  A61K51/02 ,  G21G1/10 ,  G21G4/08

摘要： A method for producing Ac-225 is presented, wherein Ac-225 is produced by bombardment of Ra-226 with deuterons accelerated in a cyclotron. The deuterons preferably have an incident energy of between 15 and 22 MeV. The method, which allows production of Ac-225 at high yields and purity levels, is particularly interesting in view of Bi-213 generation.

摘要翻译： 提出了一种生产Ac-225的方法，其中Ac-225是通过在回旋加速器中加速的氘核轰击Ra-226而产生的。 氘核优选具有15至22MeV的入射能量。 鉴于Bi-213生成，该方法以高产率和纯度水平生产Ac-225是特别有趣的。