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    Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin
    2.
    发明申请
    Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin 有权
    含有胰岛素和烟雾发生装置的液体气溶胶制剂和产生气雾化胰岛素的方法

    公开(公告)号：US20040223917A1

    公开(公告)日：2004-11-11

    申请号：US10829945

    申请日：2004-04-23

    申请人： Chrysalis Technologies Incorporated

    发明人： Michael Hindle ,  Kenneth A. Cox

    IPC分类号： A61K038/28 ,  A61L009/04

    CPC分类号： A61K9/007 ,  A61K38/28 ,  A61M11/007 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0065 ,  A61M15/008 ,  A61M15/02 ,  A61M15/025 ,  A61M2016/0039 ,  A61M2205/8206 ,  A61M2205/8237

    摘要： Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of the carrier. The carrier can be a mixture of ethanol and water and the liquid aerosol formulation can be propellant free. An aerosol generating device generates the aerosolized insulin by passing the liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor which entrains insulin particles which mix with air to form an aerosol. The insulin particles can be dry insulin particles produced by a hand held inhaler. By controlling the concentration of the insulin in the formulation, the size of the flow passage and/or the amount of heat which heats the flow passage, the aerosol can be provided with a selected mass median aerodynamic diameter of 1 to 3 nullm or less than 1 nullm so as to be delivered to a targeted portion of the lung using the inhaler.

    摘要翻译： 用于产生气雾化胰岛素的液体气溶胶制剂包括胰岛素和至少一种高挥发性载体，其保护胰岛素在载体蒸发期间的热降解。 载体可以是乙醇和水的混合物，液体气溶胶制剂可以不含推进剂。 烟雾发生装置通过使液体气溶胶制剂通过加热的流动通道将液体转化成蒸气，该蒸气夹带与空气混合以形成气溶胶的胰岛素颗粒，产生雾化的胰岛素。 胰岛素颗粒可以是由手持式吸入器产生的干性胰岛素颗粒。 通过控制制剂中胰岛素的浓度，流路的尺寸和/或加热流道的热量，气雾剂可以具有1至3μm或更小的所选质量中值空气动力学直径 1，以便使用吸入器输送到肺的目标部分。

    Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
    5.
    发明申请
    Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate 审中-公开
    具有加热器的气溶胶发生器，其布置成在层压体的接合层之间的流体通道中蒸发流体

    公开(公告)号：US20040170405A1

    公开(公告)日：2004-09-02

    申请号：US10795522

    申请日：2004-03-09

    申请人： Chrysalis Technologies Incorporated

    发明人： Timothy S. Sherwood ,  Scott A. Sowers ,  Sirisha P. Reddy ,  F. Murphy Sprinkel JR. ,  Kenneth A. Cox ,  Walter A. Nichols

    IPC分类号： F22B035/06

    CPC分类号： A61M11/041 ,  A61M11/007 ,  A61M11/042 ,  A61M15/00 ,  A61M15/025 ,  B05B17/04

    摘要： An aerosol generator includes a fluid supply which supplies fluid to a fluid passage and a heater, which heats the fluid into a gaseous state, the fluid passage being located between opposed layers of a laminate. The fluid passage can be a capillary sized passage formed by locating a mandrel between opposed layers of the laminate, bonding the layers together, and removing the mandrel such that the space previously occupied by the mandrel forms the fluid passage. The opposed layers of the laminate can be copper sheets, and ceramic layers can be provided on the outside of the copper layers. The aerosol generator can be used to generate aerosols containing medicated materials.

    摘要翻译： 气溶胶发生器包括向流体通道供应流体的流体供应器和将流体加热成气态的加热器，流体通道位于层压体的相对的层之间。 流体通道可以是通过将心轴定位在层压体的相对层之间而形成的毛细管尺寸通道，将层粘合在一起，并且移除心轴使得先前由心轴占据的空间形成流体通道。 层压体的相对层可以是铜片，并且可以在铜层的外侧设置陶瓷层。 气溶胶发生器可用于产生含有药物的气溶胶。

    Dual capillary fluid vaporizing device
    6.
    发明申请
    Dual capillary fluid vaporizing device 有权

    公开(公告)号：US20030205228A1

    公开(公告)日：2003-11-06

    申请号：US10430272

    申请日：2003-05-07

    申请人： Chrysalis Technologies Incorporated

    发明人： Walter A. Nichols ,  Kenneth A. Cox ,  Tung Tien Nguyen

    IPC分类号： A61M016/00 ,  F23D011/00

    CPC分类号： A61M15/00 ,  A61M11/007 ,  A61M11/042 ,  A61M15/025 ,  A61M2016/0024

    摘要： A fluid vaporizing device useful for vaporizing fluid into an aerosol and includes first and second capillary tubes connected electrically in series by providing separate electrodes at the inlet ends of each capillary tube, and connecting the outlet ends of the capillary tubes by an electrical connection that connects the outlet ends both electrically and thermally. The capillary tubes are heated by the flow of electricity therethrough, and liquid flowing through the tubes is vaporized. The outlet ends of the capillary tubes are easily maintained at a temperature for optimizing aerosol generation since there is minimal heat loss through the connection connecting the outlet ends.