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公开(公告)号：US11891434B2
公开(公告)日：2024-02-06
申请号：US15988348
申请日：2018-05-24
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Shinya Ishii , Miho Funaki , Naoka Hironiwa , Atsuhiko Maeda , Junichi Nezu , Yoshinao Ruike , Takeshi Baba , Shun Shimizu
CPC classification number: C07K16/18 , C07K16/248 , C07K16/2866 , C07K16/4291 , G01N33/53 , C07K2317/565
Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.
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2.发明公开公开(公告)号：US20240158482A1
公开(公告)日：2024-05-16
申请号：US18390581
申请日：2023-12-20
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Shinya Ishii , Miho Funaki , Naoka Hironiwa , Atsuhiko Maeda , Junichi Nezu , Yoshinao Ruike , Takeshi Baba , Shun Shimizu
CPC classification number: C07K16/18 , C07K16/248 , C07K16/2866 , C07K16/4291 , G01N33/53 , C07K2317/565
Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.
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Patent Agency Ranking
公开(公告)号：US20190041396A1
公开(公告)日：2019-02-07
申请号：US16010929
申请日：2018-06-18
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki IGAWA , Shinya Ishii , Miho Funaki , Naoka Hironiwa , Shun Shimizu
Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
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公开(公告)号：US10024867B2
公开(公告)日：2018-07-17
申请号：US14348511
申请日：2012-09-28
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Shinya Ishii , Miho Funaki , Naoka Hironiwa , Shun Shimizu
Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
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公开(公告)号：US11243210B2
公开(公告)日：2022-02-08
申请号：US16010929
申请日：2018-06-18
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Shinya Ishii , Miho Funaki , Naoka Hironiwa , Shun Shimizu
Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
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6.发明申请公开(公告)号：US20180258161A1
公开(公告)日：2018-09-13
申请号：US15988348
申请日：2018-05-24
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Shinya Ishii , Miho Funaki , Naoka Hironiwa , Atsuhiko Maeda , Junichi Nezu , Yoshinao Ruike , Takeshi Baba , Shun Shimizu
Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.
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公开(公告)号：US20140271617A1
公开(公告)日：2014-09-18
申请号：US14348511
申请日：2012-09-28
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Shinya Ishii , Miho Funaki , Naoka Hironiwa , Shun Shimizu
IPC: G01N33/68
CPC classification number: G01N33/6854 , C07K16/00 , C07K16/005 , C07K16/24 , C07K16/26 , C07K16/2866 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/92 , C07K2317/94 , C40B40/10 , G01N33/6845
Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
Abstract translation: 公开了一种基本上由多个彼此不同的抗原结合分子组成的文库，其中每个抗原结合分子中的抗原结合结构域包含至少一个改变抗原结合活性的氨基酸残基 抗原结合分子取决于离子浓度条件。 还公开了包含编码抗原结合分子的多个多核苷酸分子的组合物，包含多个含有多核苷酸分子的载体的组合物，选择抗原结合分子的方法，分离多核苷酸分子的方法， 抗原结合分子的制造方法以及包含任意抗原结合分子的药物组合物。
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