公开(公告)号：US20230020377A1

公开(公告)日：2023-01-19

申请号：US17848983

申请日：2022-06-24

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Hitoshi KATADA ,  Kanako Tatsumi ,  Yutaka Matsuda ,  Shun Shimizu ,  Masaki Kamimura ,  Yasunori Komori ,  Yuji Hori ,  Tomoyuki Igawa ,  Hiroki Kawauchi ,  Hiroki Hayashi ,  Hiroaki Susumu ,  Shimon Sakaguchi

IPC分类号： C07K16/28

摘要： The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.

公开(公告)号：US11660340B2

公开(公告)日：2023-05-30

申请号：US15776587

申请日：2016-11-17

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Toshiaki Tsunenari ,  Yutaka Matsuda ,  Taro Miyazaki ,  Kenji Taniguchi

IPC分类号： A61P35/00 ,  A61K39/395 ,  A61K45/00 ,  A61K31/7068 ,  A61K33/243 ,  A61K39/00

CPC分类号： A61K39/39558 ,  A61K31/7068 ,  A61K33/243 ,  A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/507

摘要： The present invention provides methods for treating or preventing cancer by administering an anticancer agent and an antigen-binding molecule comprising a domain that binds to a molecule expressed on the surface of a cell having an immune response-suppressing function and a T cell receptor complex-binding domain. The present invention also provides pharmaceutical compositions for treating or preventing cancer, each comprising a combination of the anticancer agent and the antigen-binding molecule.