公开(公告)号：US20230391752A1

公开(公告)日：2023-12-07

申请号：US18250012

申请日：2021-10-22

申请人： Chulalongkorn University

发明人： Tanachote RUENGSATRA ,  Eakkaphon RATTANANGKOOL ,  Pongkorn CHAIYAKUNVAT ,  Sirikan DEESIRI ,  Wilasinee DUNKOKSUNG ,  Udomsak UDOMNILOBOL ,  Natthaya CHUAYPEN ,  Pisit TANGKIJVANICH ,  Khanitha PUDHOM ,  Thomayant PRUEKSARITANONT

IPC分类号： C07D403/06 ,  C07D409/06 ,  C07D495/04 ,  C07D401/14 ,  C07D491/048 ,  A61P31/20 ,  C07D471/04 ,  C07D487/04 ,  A61K45/06 ,  C07D403/14 ,  C07D417/14

CPC分类号： C07D403/06 ,  C07D409/06 ,  C07D495/04 ,  C07D401/14 ,  C07D491/048 ,  A61P31/20 ,  C07D471/04 ,  C07D487/04 ,  A61K45/06 ,  C07D403/14 ,  C07D417/14

摘要： The present disclosure relates to compounds of Formula (I′):




and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for the treatment of a viral infection (e.g., hepatitis B virus or a Flaviviridae virus).

公开(公告)号：US20240336601A1

公开(公告)日：2024-10-10

申请号：US18259408

申请日：2021-12-30

申请人： Chulalongkorn University

发明人： Jakapun SOPONPONG ,  Tanachote RUENGSATRA ,  Nonthaneth NALINRATANA ,  Udomsak UDOMNILOBOL ,  Supanan AMPAWA ,  Nopparat THAVORNSIN ,  Jakkrit SRISA ,  Eakkaphon RATTANANGKOOL ,  Chayan CHAROENPAKDEE ,  Pongkorn CHAIYAKUNVAT ,  Sirikan DEESIRI ,  Songkiat SONGTHAMMANUPHAP ,  Wilasinee DUNKOKSUNG ,  Tirayut VILAIVAN ,  Supranee BURANAPRADITKUN ,  Trairak PISITKUN ,  Nattiya HIRANKARN ,  Thomayant PRUEKSARITANONT

IPC分类号： C07D405/10 ,  A61K31/397 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/546 ,  A61P35/00 ,  C07D209/08 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04 ,  C07D519/00

CPC分类号： C07D405/10 ,  A61K31/397 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/546 ,  A61P35/00 ,  C07D209/08 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04 ,  C07D519/00

摘要： The present disclosure relates to compounds of Formula (I):




and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating PD-1 activity, PD-L1 activity, and/or the PD-1/PD-L1 interaction and may be used in the treatment of disorders in which PD-1 activity, PD-L1 activity, and/or PD-1/PD-L1 interaction is implicated, such as cancer.