公开(公告)号：US08404730B2

公开(公告)日：2013-03-26

申请号：US13276804

申请日：2011-10-19

申请人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

发明人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

IPC分类号： A61K31/41 ,  C07D257/04

CPC分类号： A61K31/41 ,  A61K31/4192 ,  A61K31/4709 ,  A61K31/4725 ,  C07D249/04 ,  C07D257/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06

摘要： Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also disclosed. The subject compounds are useful for the treatment of diseases of the central nervous system, such as depression, anxiety and pain disorders.

摘要翻译： 公开了由以下结构式（I）表示的外消旋或对映异构体富集的3-取代的丙胺化合物或其药学上可接受的盐。 还公开了含有本发明化合物的药物组合物。 本发明化合物可用于治疗中枢神经系统的疾病，例如抑郁症，焦虑症和疼痛障碍。

公开(公告)号：US20120046312A1

公开(公告)日：2012-02-23

申请号：US13276804

申请日：2011-10-19

申请人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

发明人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

IPC分类号： A61K31/4725 ,  A61K31/4192 ,  A61K31/417 ,  A61P25/24 ,  A61K31/4439 ,  A61P25/04 ,  A61P25/22 ,  A61K31/41 ,  A61K31/4709

CPC分类号： A61K31/41 ,  A61K31/4192 ,  A61K31/4709 ,  A61K31/4725 ,  C07D249/04 ,  C07D257/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06

摘要： Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also disclosed. The subject compounds are useful for the treatment of diseases of the central nervous system, such as depression, anxiety and pain disorders.

摘要翻译： 公开了由以下结构式（I）表示的外消旋或对映异构体富集的3-取代的丙胺化合物或其药学上可接受的盐。 还公开了含有本发明化合物的药物组合物。 本发明化合物可用于治疗中枢神经系统的疾病，例如抑郁症，焦虑症和疼痛障碍。

公开(公告)号：US08101642B2

公开(公告)日：2012-01-24

申请号：US12477263

申请日：2009-06-03

申请人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

发明人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

IPC分类号： A61K31/41 ,  C07D257/04

CPC分类号： A61K31/41 ,  A61K31/4192 ,  A61K31/4709 ,  A61K31/4725 ,  C07D249/04 ,  C07D257/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06

摘要： Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also disclosed. The subject compounds are useful for the treatment of diseases of the central nervous system, such as depression, anxiety and pain disorders.

摘要翻译： 公开了由以下结构式（I）表示的外消旋或对映异构体富集的3-取代的丙胺化合物或其药学上可接受的盐。 还公开了含有本发明化合物的药物组合物。 本发明化合物可用于治疗中枢神经系统的疾病，例如抑郁症，焦虑症和疼痛障碍。

公开(公告)号：US20100311789A1

公开(公告)日：2010-12-09

申请号：US12477263

申请日：2009-06-03

申请人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

发明人： Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu ,  Coo-Min Chung ,  Hui-Ho Kim

IPC分类号： A61K31/41 ,  C07D257/04 ,  C07D249/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  A61K31/4192 ,  A61K31/4725 ,  A61K31/4709

CPC分类号： A61K31/41 ,  A61K31/4192 ,  A61K31/4709 ,  A61K31/4725 ,  C07D249/04 ,  C07D257/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06

摘要： Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also disclosed. The subject compounds are useful for the treatment of diseases of the central nervous system, such as depression, anxiety and pain disorders.

摘要翻译： 公开了由以下结构式（I）表示的外消旋或对映异构体富集的3-取代的丙胺化合物或其药学上可接受的盐。 还公开了含有本发明化合物的药物组合物。 本发明化合物可用于治疗中枢神经系统的疾病，例如抑郁症，焦虑症和疼痛障碍。

公开(公告)号：US20090306140A1

公开(公告)日：2009-12-10

申请号：US12477369

申请日：2009-06-03

申请人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

发明人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

IPC分类号： A61K31/454 ,  C07D401/06 ,  C07D409/14

CPC分类号： C07D401/06 ,  C07D409/14

摘要： There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I) or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder

摘要翻译： 公开了由以下结构式（I）表示的外消旋或对映体富集的3-或4-取代的哌啶化合物或其任何异构体或其药学上可接受的盐。 还公开了含有本发明化合物的药物组合物。 本发明化合物可用于治疗中枢神经系统疾病，特别是抑郁症，焦虑和疼痛障碍

公开(公告)号：US08546576B2

公开(公告)日：2013-10-01

申请号：US12477369

申请日：2009-06-03

申请人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

发明人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyun Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

IPC分类号： C07D405/00 ,  A01N43/40

CPC分类号： C07D401/06 ,  C07D409/14

摘要： There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I): or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder.

摘要翻译： 公开了由以下结构式（I）表示的外消旋或对映体富集的3-或4-取代的哌啶化合物：或其任何异构体或其药学上可接受的盐。 还公开了含有本发明化合物的药物组合物。 本发明化合物可用于治疗中枢神经系统疾病，特别是抑郁症，焦虑和疼痛障碍。

公开(公告)号：US08513285B2

公开(公告)日：2013-08-20

申请号：US13353951

申请日：2012-01-19

申请人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyan Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

发明人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyan Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

IPC分类号： A61K31/445

CPC分类号： C07D401/06 ,  C07D409/14

摘要： There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I): or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder.

公开(公告)号：US20120122927A1

公开(公告)日：2012-05-17

申请号：US13353951

申请日：2012-01-19

申请人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyan Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

发明人： Ki-Ho Lee ,  Chun-Eung Park ,  Kyung-Hyan Min ,  Yong-Je Shin ,  Yu-Jin Shin ,  Hae-Jeong Yoon ,  Won Kim ,  Eun-Ju Ryu

IPC分类号： A61K31/454 ,  A61P25/22 ,  A61P25/00 ,  A61P25/24

CPC分类号： C07D401/06 ,  C07D409/14

摘要： There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I): or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder

摘要翻译： 公开了由以下结构式（I）表示的外消旋或对映体富集的3-或4-取代的哌啶化合物：或其任何异构体或其药学上可接受的盐。 还公开了含有本发明化合物的药物组合物。 本发明化合物可用于治疗中枢神经系统疾病，特别是抑郁症，焦虑和疼痛障碍