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公开(公告)号：US20210386840A1
公开(公告)日：2021-12-16
申请号：US17141142
申请日：2021-01-04
申请人： City of Hope
发明人： Xiuli Wang , Stephen J. Forman , Don J. Diamond
IPC分类号： A61K39/00 , C07K14/705 , C12N5/0783 , C07K16/28 , A61K39/17 , A61K39/12 , A61K35/17 , C07K14/725 , A61P35/00 , A61K39/245 , C07K14/71
摘要： T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.
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公开(公告)号：US10821161B2
公开(公告)日：2020-11-03
申请号：US15533153
申请日：2015-12-07
申请人： City of Hope
发明人： Xiuli Wang , Stephen J. Forman
IPC分类号： C12N5/0783 , C07K16/28 , A61P35/00 , C07K14/71 , C07K14/705 , A61K39/00 , C07K14/35 , A61K35/17 , C07K14/725
摘要： Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
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公开(公告)号：US20240148826A1
公开(公告)日：2024-05-09
申请号：US18329365
申请日：2023-06-05
申请人： City of Hope
CPC分类号： A61K38/177 , A61K35/17 , C07K16/18 , C12N15/86 , C07K2317/622
摘要： Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ζ signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.
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公开(公告)号：US11730797B2
公开(公告)日：2023-08-22
申请号：US16992361
申请日：2020-08-13
申请人： City of Hope
发明人： Xiuli Wang , Stephen J. Forman
IPC分类号： A61K39/00 , C07K14/705 , C07K14/35 , A61K35/17 , C07K16/28 , C07K14/725 , C07K14/71 , C12N5/0783
CPC分类号： A61K39/0011 , A61K35/17 , C07K14/35 , C07K14/705 , C07K14/7051 , C07K14/70521 , C07K14/71 , C07K16/2803 , C07K16/2896 , C12N5/0636 , C12N5/0637 , C12N5/0638 , A61K2039/5156 , A61K2039/5158 , C07K2317/526 , C07K2317/53 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/033 , C12N2510/00
摘要： Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
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公开(公告)号：US20210170001A1
公开(公告)日：2021-06-10
申请号：US16992361
申请日：2020-08-13
申请人： City of Hope
发明人： Xiuli Wang , Stephen J. Forman
IPC分类号： A61K39/00 , C07K14/71 , C07K16/28 , C12N5/0783 , C07K14/705 , C07K14/725 , C07K14/35 , A61K35/17
摘要： Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
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公开(公告)号：US20210046155A1
公开(公告)日：2021-02-18
申请号：US16964471
申请日：2019-01-25
申请人： City of Hope
摘要： Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ζ signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.
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公开(公告)号：US11701405B2
公开(公告)日：2023-07-18
申请号：US16964471
申请日：2019-01-25
申请人： City of Hope
CPC分类号： A61K38/177 , A61K35/17 , C07K16/18 , C12N15/86 , C07K2317/622
摘要： Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3ζ signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.
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公开(公告)号：US20210102165A1
公开(公告)日：2021-04-08
申请号：US16989686
申请日：2020-08-10
申请人： City of Hope
发明人： Stephen J. Forman , Xiuli Wang
IPC分类号： C12N5/0783 , C07K14/725 , C07K14/705 , A61K35/17 , C07K16/28 , C07K14/73 , C07K16/30
摘要： An improved method for preparing T cell populations expressing a chimeric antigen receptor is described.
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9.发明申请公开(公告)号：US20200345823A1
公开(公告)日：2020-11-05
申请号：US16762225
申请日：2018-11-07
申请人： Xiuli WANG , Stephen J. FORMAN , City of Hope
发明人： Xiuli Wang , Stephen J. Forman
摘要： An improved method of treating cancers CD19 CAR T cells by administering the CD19 CAR T cells to the central nervous system, e.g., by intracerebroventricular administration, is described.
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公开(公告)号：US20180320133A1
公开(公告)日：2018-11-08
申请号：US15773807
申请日：2016-11-04
申请人： City of Hope
发明人： Stephen J. Forman , Xiuli Wang
IPC分类号： C12N5/0783 , C07K14/725 , C07K14/73 , C07K14/705 , C07K16/30
CPC分类号： C12N5/0636 , A61K35/17 , C07K14/7051 , C07K14/70514 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C12N5/00 , C12N2501/2302 , C12N2501/2315 , C12N2501/999
摘要： An improved method for preparing T cell populations expressing a chimeric antigen receptor is described.
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