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    Adoptive transfer of CD8+ T cell clones derived from central memory cells
    1.
    发明授权
    Adoptive transfer of CD8+ T cell clones derived from central memory cells 有权

    公开(公告)号：US10400215B2

    公开(公告)日：2019-09-03

    申请号：US14303385

    申请日：2014-06-12

    申请人： City of Hope ,  Fred Hutchinson Cancer Research Center

    发明人： Stanley R. Riddell ,  Susanna Carolina Berger ,  Michael C. Jensen

    IPC分类号： C12N5/0783 ,  A61K35/17 ,  C12N15/85 ,  A61K39/00

    摘要： The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount. The method comprises administering as the CTL preparation a preparation consisting essentially of an in vitro expanded primate CTL population, the CTL population enriched prior to expansion for central memory T lymphocytes, and depleted prior to expansion of effector memory T lymphocytes. In some embodiments, the method may further comprise concurrently administering Interleukin-15 to the subject in an amount effective to increase the proliferation of the central memory T cells in the subject. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.

    Adoptive transfer of CD8+ T cell clones derived from central memory cells
    2.
    发明授权
    Adoptive transfer of CD8+ T cell clones derived from central memory cells 有权

    公开(公告)号：US10968431B2

    公开(公告)日：2021-04-06

    申请号：US16514813

    申请日：2019-07-17

    申请人： City of Hope ,  Fred Hutchinson Cancer Research Center

    发明人： Stanley R. Riddell ,  Susanna Carolina Berger ,  Michael C. Jensen

    IPC分类号： A61K35/17 ,  C12N5/0783 ,  C12N15/85 ,  A61K39/00

    摘要： The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount. The method comprises administering as the CTL preparation a preparation consisting essentially of an in vitro expanded primate CTL population, the CTL population enriched prior to expansion for central memory T lymphocytes, and depleted prior to expansion of effector memory T lymphocytes. In some embodiments, the method may further comprise concurrently administering Interleukin-15 to the subject in an amount effective to increase the proliferation of the central memory T cells in the subject. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.