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公开(公告)号：US20220169723A1
公开(公告)日：2022-06-02
申请号：US17329115
申请日：2021-05-24
发明人： Stanley R. Riddell , Lingfeng Liu
IPC分类号： C07K16/28 , A61K38/17 , A61K35/17 , C07K14/705 , C07K14/725 , A61K38/20 , A61K35/545 , C12N5/0783 , G01N33/569
摘要： The present disclosure relates to tagged chimeric effector molecules and receptor molecules thereof for genetically engineering a host cell, wherein the recombinant host cell can be identified, isolated, sorted, induced to proliferate, tracked or eliminated. For example, a T cell may be recombinantly modified for use in adoptive immunotherapy.
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公开(公告)号：US10828352B2
公开(公告)日：2020-11-10
申请号：US15521794
申请日：2015-10-27
IPC分类号： A61K39/00 , C07K14/725 , A61K39/12 , A61K35/17 , A61K35/15 , A61K45/06 , C07K14/705 , C07K16/30 , C07K16/28 , A61K48/00
摘要： The present disclosure provides compositions and methods for boosting, augmenting or enhancing the efficacy of the adoptive cellular immunotherapy by using modified T cells expressing an antigen binding protein in conjunction with modified cells (such as hematopoietic progenitor cells, modified human immune system cells or a combination thereof) expressing the antigen specifically bound by the antigen binding protein of the modified T cells.
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3.发明申请公开(公告)号：US20180243386A1
公开(公告)日：2018-08-30
申请号：US15903214
申请日：2018-02-23
IPC分类号： A61K39/00 , C12N5/0783 , A61K35/17 , G01N33/50
CPC分类号： A61K39/00 , A61K35/17 , A61K2039/515 , A61K2039/57 , A61K2039/572 , C12N5/0636 , C12N5/0638 , C12N2501/599 , G01N33/505 , G01N2333/54 , G01N2333/70557
摘要： This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
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公开(公告)号：US20180200298A1
公开(公告)日：2018-07-19
申请号：US15817002
申请日：2017-11-17
申请人： Fred Hutchinson Cancer Research Center , Seattle Children's Hospital, dba Seattle Children's Research Institute
IPC分类号： A61K35/17 , C07K16/40 , C07K14/705 , C07K16/32 , C07K16/28 , C07K14/715 , C07K14/725
摘要： The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD8+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor. In embodiments the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a ligand binding domain, a polynucleotide comprising a customized spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain. It has been surprisingly found that the length of the spacer region can affects the ability of chimeric receptor modified T cells to recognize target cells in vitro and affects in vivo efficacy of the chimeric receptor modified T cells. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
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公开(公告)号：US20230158164A1
公开(公告)日：2023-05-25
申请号：US17601611
申请日：2020-04-04
发明人： Antonio Mario Querido Marcondes , Peter Benedict Kirk , Takahiro Miyazaki , Cameron J. Turtle , Stanley R. Riddell , Cassie K. Chou , Simon P. Fräßle
CPC分类号： A61K47/642 , A61K35/17 , C07K16/2803 , A61P35/00 , A61K9/0019 , A61K38/1774 , C07K2317/24
摘要： Provided are methods and compositions directed to the treatment of an individual having cancer by (i) administering to the individual an adoptive cellular immunotherapy composition comprising CAR T cells and (ii) administering to the individual an interleukin-15 receptor agonist, such as, for example, a long-acting interleukin-15 receptor agonist.
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公开(公告)号：US20210147540A1
公开(公告)日：2021-05-20
申请号：US17157810
申请日：2021-01-25
IPC分类号： C07K16/28 , G01N33/574
摘要： The present disclosure relates to anti-ROR1 binding proteins, including those that bind to a ROR1 or portion thereof such as an intracellular C terminal portion of a ROR1 protein, and the use of such binding proteins in immunohistochemical and diagnostic methods. Related kits and methods of using the binding proteins are also provided, as are methods of treatment of subjects having diseases or conditions determined to be candidates for such treatments by the binding proteins or methods of this disclosure.
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公开(公告)号：US10653756B2
公开(公告)日：2020-05-19
申请号：US15903214
申请日：2018-02-23
IPC分类号： C12N5/0783 , A61K39/00 , G01N33/50 , A61K35/17
摘要： This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8+ T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Rα and the capacity to rapidly efflux the fluorescent dye Rh123.
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公开(公告)号：US20190040132A1
公开(公告)日：2019-02-07
申请号：US16074737
申请日：2017-02-02
IPC分类号： C07K16/28 , G01N33/574
摘要： The present disclosure relates to anti-ROR1 binding proteins, including those that bind to a ROR1 or portion thereof such as an intracellular C terminal portion of a ROR1 protein, and the use of such binding proteins in immunohistochemical and diagnostic methods. Related kits and methods of using the binding proteins are also provided, as are methods of treatment of subjects having diseases or conditions determined to be candidates for such treatments by the binding proteins or methods of this disclosure.
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公开(公告)号：US20170267756A1
公开(公告)日：2017-09-21
申请号：US15106657
申请日：2014-12-22
发明人： Stanley R. Riddell , Lingfeng Liu
IPC分类号： C07K16/28 , G01N33/569 , A61K35/17 , C12N5/0783 , C07K14/705 , C07K14/725
CPC分类号： C07K16/2803 , A61K35/17 , A61K35/545 , A61K38/1774 , A61K38/2013 , A61K38/2086 , A61K2035/124 , A61K2039/505 , A61K2039/507 , C07K14/705 , C07K14/7051 , C07K14/70521 , C07K14/70578 , C07K16/2818 , C07K16/2878 , C07K2317/622 , C07K2317/64 , C07K2319/03 , C07K2319/20 , C07K2319/22 , C07K2319/33 , C07K2319/95 , C12N5/0637 , C12N5/0638 , C12N2501/2302 , C12N2510/00 , G01N33/56972 , A61K2300/00
摘要： The present disclosure relates to tagged chimeric effector molecules and receptor molecules thereof for genetically engineering a host cell, wherein the recombinant host cell can be identified, isolated, sorted, induced to proliferate, tracked or eliminated using the tag. An exemplary receptor molecule is a chimeric antigen receptors (CARs) having an extracellular domain comprising a binding domain for a target, a hinge region and a tag cassette, a hydrophobic portion as a transmembrane domain and, an intracellular part with an effector domain. An exemplary target is CD19, an exemplary tag is a Step-tag. T cells recombinantly modified for expression of such molecules may be used in adoptive immunotherapy.
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10.发明申请ADOPTIVE TRANSFER OF CD8+ T CELL CLONES DERIVED FROM CENTRAL MEMORY CELLS 审中-公开从中央记忆细胞衍生的CD8 + T细胞克隆的自适应转移公开(公告)号：US20140356398A1
公开(公告)日：2014-12-04
申请号：US14303385
申请日：2014-06-12
IPC分类号： C12N5/0783 , A61K35/14 , C12N15/85
CPC分类号： C12N5/0638 , A61K35/17 , A61K39/0011 , A61K2039/5158 , C12N5/0636 , C12N15/85 , C12N2501/2315
摘要： The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount. The method comprises administering as the CTL preparation a preparation consisting essentially of an in vitro expanded primate CTL population, the CTL population enriched prior to expansion for central memory T lymphocytes, and depleted prior to expansion of effector memory T lymphocytes. In some embodiments, the method may further comprise concurrently administering Interleukin-15 to the subject in an amount effective to increase the proliferation of the central memory T cells in the subject. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
摘要翻译： 本发明提供了在有需要的灵长类动物受试者中通过以治疗有效量给予受试者细胞毒性T淋巴细胞（CTL）制剂来进行过继性免疫治疗的方法。 该方法包括作为CTL制剂施用基本上由体外扩增的灵长类动物CTL群体组成的制剂，在扩增中间记忆T淋巴细胞之前富集的CTL群体，并在效应记忆T淋巴细胞扩增之前耗尽。 在一些实施方案中，该方法可以进一步包括以有效增加受试者中央记忆T细胞增殖的量同时向受试者施用白细胞介素-15。 还描述了通过该方法制备的药物制剂及其使用方法。
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