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公开(公告)号：US08343966B2
公开(公告)日：2013-01-01
申请号：US12319234
申请日：2009-01-02
申请人： Claire Adcock , Urs Baettig , Peter Hunt , Catherine Leblanc , Maude Nadine Pierrette Pipet , Robert Alexander Pulz , Katrin Spiegel , Nikolaus Johannes Stiefl
发明人： Claire Adcock , Urs Baettig , Peter Hunt , Catherine Leblanc , Maude Nadine Pierrette Pipet , Robert Alexander Pulz , Katrin Spiegel , Nikolaus Johannes Stiefl
IPC分类号： A61K31/5355 , A61K31/536 , A61K31/496 , A61K31/506 , A61K31/4453 , A61K31/444 , A61K31/4402 , A61K31/443 , A61K31/4439 , C07D401/14 , C07D405/14 , C07D413/14 , C07D211/04 , C07D211/48 , C07D211/62 , C07D213/53
CPC分类号： C07D405/14 , C07D213/74 , C07D401/14 , C07D409/14 , C07D413/14
摘要： Compounds of formula I in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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公开(公告)号：US20090215776A1
公开(公告)日：2009-08-27
申请号：US12319234
申请日：2009-01-02
申请人： Claire Adcock , Urs Baettig , Peter Hunt , Catherine Leblanc , Maude Nadine Pierrette Pipet , Robert Alexander Pulz , Katrin Spiegel , Nikolaus Johannes Stiefl
发明人： Claire Adcock , Urs Baettig , Peter Hunt , Catherine Leblanc , Maude Nadine Pierrette Pipet , Robert Alexander Pulz , Katrin Spiegel , Nikolaus Johannes Stiefl
IPC分类号： A61K31/5377 , C07D405/14 , A61K31/444 , C07D413/14 , C07D401/14 , A61K31/496 , A61P19/02
CPC分类号： C07D405/14 , C07D213/74 , C07D401/14 , C07D409/14 , C07D413/14
摘要： Compounds of formula I in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 具有游离或盐或溶剂合物形式的式I化合物，其中T1，T2，X，Ra，Rb，R8和R9具有说明书中指出的含义，可用于治疗炎性或阻塞性气道，肺动脉高压，肺纤维化， 肝纤维化，肌肉疾病和系统性骨骼疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US07989458B2
公开(公告)日：2011-08-02
申请号：US12308232
申请日：2007-07-12
申请人： Catherine Leblanc , Maude Nadine Pierrette Pipet , Robin Alec Fairhurst , Claire Adcock , Robert Alexander Pulz , Duncan Shaw , Nikolaus Johannes Stiefl
发明人： Catherine Leblanc , Maude Nadine Pierrette Pipet , Robin Alec Fairhurst , Claire Adcock , Robert Alexander Pulz , Duncan Shaw , Nikolaus Johannes Stiefl
IPC分类号： A01N43/54 , C07D239/02 , C07D239/42 , C07D401/00 , C07D401/04 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中T1，T2，Ra和Rb具有说明书中所述的含义，可用于治疗炎性或阻塞性气道，肺动脉高压，肺纤维化，肝纤维化，肌肉 疾病和系统性骨骼疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20090209539A1
公开(公告)日：2009-08-20
申请号：US12308232
申请日：2007-07-12
申请人： Catherine Leblanc , Maude Nadine Pierrette Pipet , Robin Alec Fairhurst , Claire Adcock , Robert Alexander Pulz , Duncan Shaw , Nikolaus Johannes Stiefl
发明人： Catherine Leblanc , Maude Nadine Pierrette Pipet , Robin Alec Fairhurst , Claire Adcock , Robert Alexander Pulz , Duncan Shaw , Nikolaus Johannes Stiefl
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , C07D413/14 , C07D401/14
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中T1，T2，Ra和Rb具有说明书中所述的含义，可用于治疗炎性或阻塞性气道，肺动脉高压，肺纤维化，肝纤维化，肌肉 疾病和系统性骨骼疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US08431578B2
公开(公告)日：2013-04-30
申请号：US12810948
申请日：2009-01-09
IPC分类号： A61K31/497 , A61K31/513 , A61K31/506 , C07D401/14
CPC分类号： C07D401/14
摘要： Compounds of formula (I) in free or salt or solvate form, where T1, T2, and T3 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中T1，T2和T3具有说明书中指出的含义，可用于治疗炎性或阻塞性气道，肺动脉高压，肺纤维化，肝纤维化，肌肉疾病 和系统性骨骼疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20100298337A1
公开(公告)日：2010-11-25
申请号：US12810948
申请日：2009-01-09
IPC分类号： A61K31/497 , C07D401/14 , A61K31/513 , A61K31/506 , A61P11/14 , A61P11/08 , A61P11/02 , A61P29/00 , A61P9/12 , A61P13/12 , A61P9/00 , A61P19/10 , A61P25/28 , A61P35/00 , A61P9/10 , A61P1/04 , A61P27/02
CPC分类号： C07D401/14
摘要： Compounds of formula (I) in free or salt or solvate form, where T1, T2, and T3 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂合物形式的式（I）化合物，其中T1，T2和T3具有说明书中指出的含义，可用于治疗炎性或阻塞性气道，肺动脉高压，肺纤维化，肝纤维化，肌肉疾病 和系统性骨骼疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US08314112B2
公开(公告)日：2012-11-20
申请号：US12351438
申请日：2009-01-09
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂化物形式的式I化合物，其中X，T1，T3和T4具有说明书中所示的含义，可用于治疗由ALK-5和/或ALK-4受体介导的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20090181941A1
公开(公告)日：2009-07-16
申请号：US12351438
申请日：2009-01-09
IPC分类号： A61K31/437 , C07D487/04 , A61K31/519 , A61K31/5377 , A61P19/00 , C07D471/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐或溶剂化物形式的式I化合物，其中X，T1，T3和T4具有说明书中所示的含义，可用于治疗由ALK-5和/或ALK-4受体介导的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20140243306A1
公开(公告)日：2014-08-28
申请号：US14130536
申请日：2012-07-07
申请人： Richard Heng , Elizabeth Kate Hoegenauer , Guido Koch , Robert Alexander Pulz , Anna Vulpetti , Rudolf Waelchli
发明人： Richard Heng , Elizabeth Kate Hoegenauer , Guido Koch , Robert Alexander Pulz , Anna Vulpetti , Rudolf Waelchli
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： A61K31/519 , C07D487/04
摘要： The present invention describes new pyrrolo pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel pyrrolo pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.
摘要翻译： 本发明描述了与布鲁顿酪氨酸激酶（Btk）相互作用的新的吡咯并嘧啶衍生物及其药学上可接受的盐。 因此，新的吡咯并嘧啶可能有效治疗自身免疫疾病，炎性疾病，过敏性疾病，气道疾病如哮喘和慢性阻塞性肺疾病（COPD），移植排斥反应，癌症。 的造血起源或实体瘤。
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公开(公告)号：US09403833B2
公开(公告)日：2016-08-02
申请号：US14711693
申请日：2015-05-13
申请人： Anne-Marie Edwards , Mahbub Ahmed , Robert Alexander Pulz , Lisa Ann Rooney , Nichola Smith , Thomas Josef Troxler
发明人： Anne-Marie Edwards , Mahbub Ahmed , Robert Alexander Pulz , Lisa Ann Rooney , Nichola Smith , Thomas Josef Troxler
IPC分类号： C07D487/04 , A61K31/4192 , A61K31/55 , C07D403/12 , C07D413/14 , C07D413/12
CPC分类号： A61K31/4192 , A61K31/55 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐或共结晶; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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