公开(公告)号：US20120215087A1

公开(公告)日：2012-08-23

申请号：US13504858

申请日：2010-11-02

申请人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

发明人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

IPC分类号： A61B5/00

CPC分类号： G16H40/40 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G06F19/00

摘要： In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor (818) at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed (822) using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b. A recalibration signal, including the estimation of a and b, is transmitted to the continuous glucose monitoring sensor (824) based on the linear regression.

摘要翻译： 在可以在数字处理器上操作的用户重新校准连续葡萄糖监测数据的方法中，接收到用户已经吃了饭的指示（806）。 在与用户进餐时相对应的一天内的两个不同时间，对来自用户（810）的血糖水平进行自我监测。 葡萄糖信号从连续葡萄糖监测传感器（818）接收，时间对应于用户吃饭的两个分开的时间。 在从用户接收到至少两次自我监测的血糖水平的时候，基于来自连续监测传感器的葡萄糖信号的两个重建血糖值。 使用y = ax + b进行线性回归（822），其中x对应于两个重建的血糖值，y对应于血糖水平的两个自我监测，从而产生a和b的估计。 基于线性回归，包括估计a和b的重新校正信号被传送到连续葡萄糖监测传感器（824）。

公开(公告)号：US09858386B2

公开(公告)日：2018-01-02

申请号：US13504858

申请日：2010-11-02

申请人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

发明人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

IPC分类号： A61B5/00 ,  G06F19/00 ,  A61B5/145 ,  A61B5/1495

CPC分类号： G16H40/40 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G06F19/00

摘要： In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor (818) at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed (822) using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b. A recalibration signal, including the estimation of a and b, is transmitted to the continuous glucose monitoring sensor (824) based on the linear regression.

公开(公告)号：US20100262117A1

公开(公告)日：2010-10-14

申请号：US12740275

申请日：2008-10-31

申请人： Lalo Magni ,  Giuseppe De Nicolao ,  Davide Martino Raimondo ,  Claudio Cobelli ,  Chiara Dalla Man

发明人： Lalo Magni ,  Giuseppe De Nicolao ,  Davide Martino Raimondo ,  Claudio Cobelli ,  Chiara Dalla Man

IPC分类号： A61M37/00

CPC分类号： G06F19/3468 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7275 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2230/201 ,  G16H50/50

摘要： A system and method for providing optimal insulin injections to a subject, using a controller, a continuous glucose monitor, and an insulin delivery unit is disclosed. The controller possesses a discrete-time, linear model predictive control law, means for sending information to the insulin delivery unit, and means for receiving information from the CGM. The control law implemented is derived from a discrete-time model of glucose insulin dynamics and an aggressiveness parameter. The result is that using only glucose measurements obtained from sensor readings and, prior values of external insulin infusion and meal and exercise announcement the optimal insulin injection necessary to safely regulate blood glucose can be calculated.

摘要翻译： 公开了一种使用控制器，连续葡萄糖监测器和胰岛素递送单元向受试者提供最佳胰岛素注射的系统和方法。 控制器具有离散时间线性模型预测控制规则，用于向胰岛素递送单元发送信息的装置，以及用于从CGM接收信息的装置。 实施的控制规律来自葡萄糖胰岛素动力学的离散时间模型和侵略性参数。 结果是，仅使用从传感器读数获得的葡萄糖测量值，以及外部胰岛素输注和膳食和运动通知的先前值可以计算安全调节血糖所需的最佳胰岛素注射。

公开(公告)号：US09827371B2

公开(公告)日：2017-11-28

申请号：US14389936

申请日：2012-03-23

申请人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

发明人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

IPC分类号： A61B5/145 ,  A61M5/172 ,  A61M5/142 ,  G06F19/00

CPC分类号： A61M5/1723 ,  A61M5/14276 ,  A61M2005/14208 ,  A61M2205/04 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3468 ,  G16H50/20

摘要： A method (400) controls the delivery of insulin in a diabetic patient (P) based on data (d) representative of at least a fraction of a meal (m(k+i)) that the patient (P) will consume. The method provides from a block (R) representative of conventional therapy or open loop rule that the patient (P) is subject to, based on the data (d) representative of at least a fraction of the meal (m(k+i)), a reference insulin value (u0). The method is also based on data representative of the difference between input data (ŷ), a reference glycemic level, and feedback data (yCGM) representative of the glycemic level detected in the patient (P). A control module (301; 401) provides a value of insulin (i) to be delivered to the patient (P) based on the various representative data.

公开(公告)号：US20150174322A1

公开(公告)日：2015-06-25

申请号：US14389936

申请日：2012-03-23

申请人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

发明人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

IPC分类号： A61M5/172 ,  G06F19/00 ,  A61M5/142

CPC分类号： A61M5/1723 ,  A61M5/14276 ,  A61M2005/14208 ,  A61M2205/04 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3468 ,  G16H50/20

摘要： A method (400) controls the delivery of insulin in a diabetic patient (P) based on data (d) representative of at least a fraction of a meal (m(k+i)) that the patient (P) will consume. The method provides from a block (R) representative of conventional therapy or open loop rule that the patient (P) is subject to, based on the data (d) representative of at least a fraction of the meal (m(k+i)), a reference insulin value (u0). The method is also based on data representative of the difference between input data (ŷ), a reference glycemic level, and feedback data (yCGM) representative of the glycemic level detected in the patient (P). A control module (301; 401) provides a value of insulin (i) to be delivered to the patient (P) based on the various representative data.

摘要翻译： 方法（400）基于代表患者（P）将消费的膳食的至少一部分（m（k + i））的数据（d）来控制糖尿病患者（P）中胰岛素的递送。 该方法基于代表膳食的至少一部分（m（k + i））的数据（d），从代表患者（P）的常规治疗或开环规则的块（R） ），参考胰岛素值（u0）。 该方法还基于表示在患者（P）中检测到的血糖水平的输入数据（ŷ），参考血糖水平和反馈数据（yCGM）之间的差异的数据。 控制模块（301; 401）基于各种代表性数据提供要传送给患者（P）的胰岛素（i）的值。