公开(公告)号：US09827371B2

公开(公告)日：2017-11-28

申请号：US14389936

申请日：2012-03-23

申请人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

发明人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

IPC分类号： A61B5/145 ,  A61M5/172 ,  A61M5/142 ,  G06F19/00

CPC分类号： A61M5/1723 ,  A61M5/14276 ,  A61M2005/14208 ,  A61M2205/04 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3468 ,  G16H50/20

摘要： A method (400) controls the delivery of insulin in a diabetic patient (P) based on data (d) representative of at least a fraction of a meal (m(k+i)) that the patient (P) will consume. The method provides from a block (R) representative of conventional therapy or open loop rule that the patient (P) is subject to, based on the data (d) representative of at least a fraction of the meal (m(k+i)), a reference insulin value (u0). The method is also based on data representative of the difference between input data (ŷ), a reference glycemic level, and feedback data (yCGM) representative of the glycemic level detected in the patient (P). A control module (301; 401) provides a value of insulin (i) to be delivered to the patient (P) based on the various representative data.

公开(公告)号：US20130231543A1

公开(公告)日：2013-09-05

申请号：US13785384

申请日：2013-03-05

申请人： Andrea Facchinetti ,  Simone Del Favero ,  Giovanni Sparacino ,  Claudio Cobelli

发明人： Andrea Facchinetti ,  Simone Del Favero ,  Giovanni Sparacino ,  Claudio Cobelli

IPC分类号： A61B5/00 ,  A61M5/14 ,  A61B5/145

CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/725 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/743 ,  A61B5/7455 ,  A61B5/746 ,  A61M5/14 ,  A61M5/14276 ,  A61M2202/0468 ,  A61M2205/18 ,  G06F19/3468 ,  G16H40/63

摘要： A device for monitoring a diabetic patient includes continuous glucose monitoring system that is configured to generate glucose data indicative of the patient's actual glucose level. An continuous subcutaneous insulin infusion pump is configured to inject insulin into the patient and that is configured to generate insulin data regarding when and how much insulin has been injected into the patient. A processor, programmed with a discrete-time reiterative filter, calculates a predicted glucose level corresponding to a predicted glucose level currently expected to be sensed by the continuous glucose monitoring system, based on the insulin data and the glucose data over time and is also programed to generate an alert when the actual glucose level is different from the predicted glucose level by a predetermined amount. An alert generating device is coupled to the processor and is configured to generate an aesthetically-sensible event corresponding to the generation of the alert.

摘要翻译： 用于监测糖尿病患者的装置包括连续葡萄糖监测系统，其被配置为产生指示患者实际葡萄糖水平的葡萄糖数据。 连续皮下胰岛素输注泵被配置为将胰岛素注射到患者体内，并配置成产生胰岛素数据，该胰岛素数据关于何时以及多少胰岛素被注射到患者体内。 用离散时间重复滤波器编程的处理器基于胰岛素数据和葡萄糖数据随时间计算与目前预期由连续葡萄糖监测系统预测的葡萄糖水平相对应的预测葡萄糖水平，并且还被编程 当实际葡萄糖水平与预测的葡萄糖水平不同预定量时产生警报。 警报生成装置耦合到处理器，并且被配置为产生对应于警报的生成的美学上合适的事件。

公开(公告)号：US20120215087A1

公开(公告)日：2012-08-23

申请号：US13504858

申请日：2010-11-02

申请人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

发明人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

IPC分类号： A61B5/00

CPC分类号： G16H40/40 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G06F19/00

摘要： In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor (818) at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed (822) using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b. A recalibration signal, including the estimation of a and b, is transmitted to the continuous glucose monitoring sensor (824) based on the linear regression.

摘要翻译： 在可以在数字处理器上操作的用户重新校准连续葡萄糖监测数据的方法中，接收到用户已经吃了饭的指示（806）。 在与用户进餐时相对应的一天内的两个不同时间，对来自用户（810）的血糖水平进行自我监测。 葡萄糖信号从连续葡萄糖监测传感器（818）接收，时间对应于用户吃饭的两个分开的时间。 在从用户接收到至少两次自我监测的血糖水平的时候，基于来自连续监测传感器的葡萄糖信号的两个重建血糖值。 使用y = ax + b进行线性回归（822），其中x对应于两个重建的血糖值，y对应于血糖水平的两个自我监测，从而产生a和b的估计。 基于线性回归，包括估计a和b的重新校正信号被传送到连续葡萄糖监测传感器（824）。

公开(公告)号：US20100179768A1

公开(公告)日：2010-07-15

申请号：US12664444

申请日：2008-06-20

申请人： Boris P. Kovatchev ,  Marc D. Breton ,  Claudio Cobelli ,  Chiara Dalla Man

发明人： Boris P. Kovatchev ,  Marc D. Breton ,  Claudio Cobelli ,  Chiara Dalla Man

IPC分类号： G06F19/00 ,  G01N33/48

摘要： A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.

摘要翻译： 1型糖尿病监测方法，开环和闭环治疗策略的电脑测试模拟环境。 模拟环境的一些示例性主要组成部分包括但不限于以下内容：1）在三个年龄组中具有1型糖尿病的计算机“受试者”的“群体” 2）CGM传感器误差的模拟器; 3）胰岛素泵和离散胰岛素输送的模拟器; 4）允许输入用户指定的治疗方案的界面; 和5）一套评估测试治疗策略质量的标准化结果测量和图表。 这些组分可以单独使用或组合使用，用于糖尿病的开环或闭环控制治疗的临床前评估。

公开(公告)号：US11238990B2

公开(公告)日：2022-02-01

申请号：US13380839

申请日：2010-06-25

申请人： Boris P. Kovatchev ,  Claudio Cobelli ,  Chiara Dalla Man

发明人： Boris P. Kovatchev ,  Claudio Cobelli ,  Chiara Dalla Man

IPC分类号： G16H10/00 ,  G16H50/50 ,  G16H50/70 ,  G06N5/00 ,  G16H10/60 ,  A61B5/00 ,  G16H50/20

摘要： An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values.

公开(公告)号：US10546659B2

公开(公告)日：2020-01-28

申请号：US12664444

申请日：2008-06-20

申请人： Boris P. Kovatchev ,  Marc D. Breton ,  Claudio Cobelli ,  Chiara Dalla Man

发明人： Boris P. Kovatchev ,  Marc D. Breton ,  Claudio Cobelli ,  Chiara Dalla Man

IPC分类号： G16H50/50 ,  G16H20/17

摘要： A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.

公开(公告)号：US20100262117A1

公开(公告)日：2010-10-14

申请号：US12740275

申请日：2008-10-31

申请人： Lalo Magni ,  Giuseppe De Nicolao ,  Davide Martino Raimondo ,  Claudio Cobelli ,  Chiara Dalla Man

发明人： Lalo Magni ,  Giuseppe De Nicolao ,  Davide Martino Raimondo ,  Claudio Cobelli ,  Chiara Dalla Man

IPC分类号： A61M37/00

CPC分类号： G06F19/3468 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7275 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2230/201 ,  G16H50/50

摘要： A system and method for providing optimal insulin injections to a subject, using a controller, a continuous glucose monitor, and an insulin delivery unit is disclosed. The controller possesses a discrete-time, linear model predictive control law, means for sending information to the insulin delivery unit, and means for receiving information from the CGM. The control law implemented is derived from a discrete-time model of glucose insulin dynamics and an aggressiveness parameter. The result is that using only glucose measurements obtained from sensor readings and, prior values of external insulin infusion and meal and exercise announcement the optimal insulin injection necessary to safely regulate blood glucose can be calculated.

摘要翻译： 公开了一种使用控制器，连续葡萄糖监测器和胰岛素递送单元向受试者提供最佳胰岛素注射的系统和方法。 控制器具有离散时间线性模型预测控制规则，用于向胰岛素递送单元发送信息的装置，以及用于从CGM接收信息的装置。 实施的控制规律来自葡萄糖胰岛素动力学的离散时间模型和侵略性参数。 结果是，仅使用从传感器读数获得的葡萄糖测量值，以及外部胰岛素输注和膳食和运动通知的先前值可以计算安全调节血糖所需的最佳胰岛素注射。

公开(公告)号：US09858386B2

公开(公告)日：2018-01-02

申请号：US13504858

申请日：2010-11-02

申请人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

发明人： Claudio Cobelli ,  Giuseppe De Nicolao ,  Andrea Facchinetti ,  Stefania Guerra ,  Giovanni Sparacino

IPC分类号： A61B5/00 ,  G06F19/00 ,  A61B5/145 ,  A61B5/1495

CPC分类号： G16H40/40 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G06F19/00

摘要： In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor (818) at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed (822) using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b. A recalibration signal, including the estimation of a and b, is transmitted to the continuous glucose monitoring sensor (824) based on the linear regression.

公开(公告)号：US20150174322A1

公开(公告)日：2015-06-25

申请号：US14389936

申请日：2012-03-23

申请人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

发明人： Paola Soru ,  Lalo Magni ,  Chiara Toffanin ,  Giuseppe De Nicolao ,  Chiara Dalla Man ,  Claudio Cobelli

IPC分类号： A61M5/172 ,  G06F19/00 ,  A61M5/142

CPC分类号： A61M5/1723 ,  A61M5/14276 ,  A61M2005/14208 ,  A61M2205/04 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3468 ,  G16H50/20

摘要： A method (400) controls the delivery of insulin in a diabetic patient (P) based on data (d) representative of at least a fraction of a meal (m(k+i)) that the patient (P) will consume. The method provides from a block (R) representative of conventional therapy or open loop rule that the patient (P) is subject to, based on the data (d) representative of at least a fraction of the meal (m(k+i)), a reference insulin value (u0). The method is also based on data representative of the difference between input data (ŷ), a reference glycemic level, and feedback data (yCGM) representative of the glycemic level detected in the patient (P). A control module (301; 401) provides a value of insulin (i) to be delivered to the patient (P) based on the various representative data.

摘要翻译： 方法（400）基于代表患者（P）将消费的膳食的至少一部分（m（k + i））的数据（d）来控制糖尿病患者（P）中胰岛素的递送。 该方法基于代表膳食的至少一部分（m（k + i））的数据（d），从代表患者（P）的常规治疗或开环规则的块（R） ），参考胰岛素值（u0）。 该方法还基于表示在患者（P）中检测到的血糖水平的输入数据（ŷ），参考血糖水平和反馈数据（yCGM）之间的差异的数据。 控制模块（301; 401）基于各种代表性数据提供要传送给患者（P）的胰岛素（i）的值。

公开(公告)号：US20120245556A1

公开(公告)日：2012-09-27

申请号：US13393647

申请日：2010-08-31

申请人： Boris P. Kovatchev ,  Giuseppe DeNicolao ,  Lalo Magni ,  Chiara Dalla Man ,  Claudio Cobelli

发明人： Boris P. Kovatchev ,  Giuseppe DeNicolao ,  Lalo Magni ,  Chiara Dalla Man ,  Claudio Cobelli

IPC分类号： A61M5/168

CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/4839 ,  A61M2230/201 ,  G06F19/3468 ,  G16H50/50

摘要： A method, system and computer program product for correcting a nominal treatment strategy of a subject with diabetes. The method, system and computer program product may be configured for providing input whereby the input may include: open-loop therapy settings for the subject, data about glycemic state of the subject; and (optionally) data about meals and/or exercise of the subject. The method, system and computer program product may be configured for providing output, whereby the out-put may include an adjustment (correction) to the open-loop therapy settings for the subject for insulin delivery to the subject.

摘要翻译： 一种用于校正患有糖尿病的受试者的名义治疗策略的方法，系统和计算机程序产品。 方法，系统和计算机程序产品可以被配置用于提供输入，由此输入可以包括：用于对象的开环治疗设置，关于对象的血糖状态的数据; 和（可选）有关膳食和/或运动受试者的数据。 方法，系统和计算机程序产品可以被配置用于提供输出，由此输出可以包括针对受试者的胰岛素递送给对象的开环治疗设置的调整（校正）。