公开(公告)号：US20050064505A1

公开(公告)日：2005-03-24

申请号：US10332370

申请日：2001-06-13

申请人： Claudio Soto-Jara ,  Gabriella Saborio

发明人： Claudio Soto-Jara ,  Gabriella Saborio

IPC分类号： G01N33/68 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N2800/2828

摘要： A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.

摘要翻译： 描述了通过测定样品中这种疾病的标志物（致病构象异构体）来诊断或检测构象疾病的方法，该方法包括循环扩增系统以增加引起这种疾病的致病性构象异构体的水平。 特别地，这种传播性构象疾病可能是朊病毒性脑病。 还公开了基于这些方法的测定，诊断试剂盒和仪器。

公开(公告)号：US07351526B2

公开(公告)日：2008-04-01

申请号：US10332370

申请日：2001-06-13

申请人： Claudio Soto ,  Gabriella Saborio

发明人： Claudio Soto ,  Gabriella Saborio

IPC分类号： A61K38/00 ,  C07K16/00

CPC分类号： G01N33/6896 ,  G01N2800/2828

摘要： A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.

摘要翻译： 描述了通过测定样品中这种疾病的标志物（致病构象异构体）来诊断或检测构象疾病的方法，该方法包括循环扩增系统以增加引起这种疾病的致病性构象异构体的水平。 特别地，这种传播性构象疾病可能是朊病毒性脑病。 还公开了基于这些方法的测定，诊断试剂盒和仪器。