公开(公告)号：US20220280341A1

公开(公告)日：2022-09-08

申请号：US17547801

申请日：2021-12-10

Applicant: Clearside Biomedical, Inc. ,  Georgia Tech Research Corporation ,  Emory University

Inventor： Mark A Prausnitz ,  Henry F. Edelhauser ,  Vladimir G. Zarnitsyn ,  Samirkumar R. Patel ,  Hans Grossniklaus

IPC: A61F9/00 ,  A61M37/00 ,  A61B5/15

Abstract: A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication with the cartridge. The proximal end portion includes a base surface that is configured to be placed in contact with a surface of a target tissue. The distal end portion of the microneedle includes a beveled surface. The beveled surface defines a tip angle of less than about 20 degrees and a ratio of a bevel height to a bevel width of less than about 2.5.

公开(公告)号：US10188550B2

公开(公告)日：2019-01-29

申请号：US14894161

申请日：2014-05-30

Applicant: Clearside Biomedical, Inc.

Inventor： Rafael Victor Andino ,  Samirkumar R. Patel ,  Vladimir Zarnitsyn ,  Christopher John Brooks

IPC: A61F9/00 ,  A61M5/19 ,  A61J1/20 ,  A61M5/315 ,  A61M5/28

Abstract: A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.

公开(公告)号：US20170273827A1

公开(公告)日：2017-09-28

申请号：US15619065

申请日：2017-06-09

Applicant: Clearside Biomedical, Inc. ,  Georgia Tech Research Corporation ,  Emory University

Inventor： Mark R. Prausnitz ,  Henry F. Edelhauser ,  Vladimir G. Zarnitsyn ,  Samirkumar R. Patel ,  Hans Grossniklaus

IPC: A61F9/00 ,  A61B5/15 ,  A61M37/00 ,  A61M5/32

CPC classification number: A61F9/0017 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150503 ,  A61M5/3286 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0061

Abstract: A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication with the cartridge. The proximal end portion includes a base surface that is configured to be placed in contact with a surface of a target tissue. The distal end portion of the microneedle includes a beveled surface. The beveled surface defines a tip angle of less than about 20 degrees and a ratio of a bevel height to a bevel width of less than about 2.5.

公开(公告)号：US20150209180A1

公开(公告)日：2015-07-30

申请号：US14424685

申请日：2013-08-27

Applicant: Clearside Biomedical, Inc. ,  Georgia Tech Research Corporation ,  Emory University

Inventor： Mark R. Prausnitz ,  Henry F. Edelhauser ,  Vladimir G. Zarnitsyn ,  Samirkumar R. Patel ,  Hans Grossniklaus

IPC: A61F9/00 ,  A61M37/00

CPC classification number: A61F9/0017 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150503 ,  A61M5/3286 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0061

Abstract: A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication with the cartridge. The proximal end portion includes a base surface that is configured to be placed in contact with a surface of a target tissue. The distal end portion of the microneedle includes a beveled surface. The beveled surface defines a tip angle of less than about 20 degrees and a ratio of a bevel height to a bevel width of less than about 2.5.

Abstract translation: 微针具有近端部分和远端部分并且限定内腔。 近端部分被配置为联接到药筒以使内腔与药筒流体连通。 近端部分包括被配置为与靶组织的表面接触放置的基面。 微针的远端部分包括斜面。 倾斜的表面限定了小于约20度的尖端角度，并且斜面高度与斜面宽度的比率小于约2.5。