公开(公告)号：US11987818B2

公开(公告)日：2024-05-21

申请号：US17330686

申请日：2021-05-26

Applicant: Codexis, Inc.

Inventor： Margie Tabuga Borra-Garske ,  Oscar Alvizo ,  Melissa Ann Mayo ,  Stephan Jenne ,  Auric Anthony Sowell-Kantz ,  Carmela Molinaro

IPC: C12N9/06 ,  C12N9/02

CPC classification number: C12N9/0028 ,  C12N9/0036 ,  C12Y105/01 ,  C12Y106/00

Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US20210284973A1

公开(公告)日：2021-09-16

申请号：US17330686

申请日：2021-05-26

Applicant: Codexis, Inc.

Inventor： Margie Tabuga Borra-Garske ,  Oscar Alvizo ,  Melissa Ann Mayo ,  Stephan Jenne ,  Auric Anthony Sowell-Kantz ,  Carmela Molinaro

IPC: C12N9/06 ,  C12N9/02

Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US11046936B2

公开(公告)日：2021-06-29

申请号：US16319537

申请日：2017-08-08

Applicant: Codexis, Inc.

Inventor： Margie Tabuga Borra-Garske ,  Oscar Alvizo ,  Melissa Ann Mayo ,  Stephan Jenne ,  Auric Anthony Sowell-Kantz ,  Carmela Molinaro

IPC: C12N9/96 ,  C12N9/02 ,  C12N9/06

Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US20240254457A1

公开(公告)日：2024-08-01

申请号：US18638060

申请日：2024-04-17

Applicant: Codexis, Inc.

Inventor： Margie Borra-Garsek ,  Oscar Alvizo ,  Melissa Mayo ,  Stephan Jenne ,  Auric Anthoney Sowell-Kantz ,  Carmela Molinaro

IPC: C12N9/06 ,  C12N9/02

CPC classification number: C12N9/0028 ,  C12N9/0036 ,  C12Y105/01 ,  C12Y106/00

Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US20200208123A1

公开(公告)日：2020-07-02

申请号：US16319537

申请日：2017-08-08

Applicant: Codexis, Inc.

Inventor： Margie Tabuga Borra-Garske ,  Oscar Alvizo ,  Melissa Ann Mayo ,  Stephan Jenne ,  Auric Anthony Sowell-Kantz ,  Carmela Molinaro

IPC: C12N9/06 ,  C12N9/02

Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone amine substrate compounds to prepare secondary and tertiary amine product compounds.