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1.发明授权公开(公告)号：US11987818B2
公开(公告)日：2024-05-21
申请号：US17330686
申请日：2021-05-26
Applicant: Codexis, Inc.
Inventor： Margie Tabuga Borra-Garske , Oscar Alvizo , Melissa Ann Mayo , Stephan Jenne , Auric Anthony Sowell-Kantz , Carmela Molinaro
CPC classification number: C12N9/0028 , C12N9/0036 , C12Y105/01 , C12Y106/00
Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号：US20250027094A1
公开(公告)日：2025-01-23
申请号：US18906502
申请日：2024-10-04
Applicant: Codexis, Inc.
Inventor： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark A. Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay H. Russell , Keith A. Canada
IPC: C12N15/63
Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US12110493B2
公开(公告)日：2024-10-08
申请号：US17490215
申请日：2021-09-30
Applicant: Codexis, Inc.
Inventor： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark A. Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay H. Russell , Keith A. Canada
IPC: C12N15/63
CPC classification number: C12N15/63 , C12Y204/02001
Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20240301367A1
公开(公告)日：2024-09-12
申请号：US18655701
申请日：2024-05-06
Applicant: Codexis, Inc.
Inventor： Da Duan , Auric Anthony Sowell-Kantz , Aksiniya Lyubenova Petkova , Jovana Nazor , Nandhitha Subramanian , Oscar Alvizo
IPC: C12N9/08
CPC classification number: C12N9/0065
Abstract: The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing peroxidase enzymes are also provided. The present invention further provides compositions comprising the peroxidase enzymes and methods of using the engineered peroxidase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US12012620B2
公开(公告)日：2024-06-18
申请号：US17635163
申请日：2020-09-03
Applicant: Codexis, Inc.
Inventor： Da Duan , Auric Anthony Sowell-Kantz , Aksiniya Lyubenova Petkova , Jovana Nazor , Nandhitha Subramanian , Oscar Alvizo
IPC: C12N9/08
CPC classification number: C12N9/0065
Abstract: The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing peroxidase enzymes are also provided. The present invention further provides compositions comprising the peroxidase enzymes and methods of using the engineered peroxidase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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Patent Agency Ranking
公开(公告)号：US20240158766A1
公开(公告)日：2024-05-16
申请号：US18413338
申请日：2024-01-16
Applicant: Codexis, Inc.
Inventor： Da Duan , Auric Anthony Sowell-Kantz , Aksiniya Lyubenova Petkova , Oscar Alvizo
IPC: C12N9/12
CPC classification number: C12N9/1229 , C12Y207/04003
Abstract: The present invention provides engineered adenylate kinase (AdK) enzymes, polypeptides having AdK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AdK enzymes are also provided. The present invention further provides compositions comprising the AdK enzymes and methods of using the engineered AdK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20220010316A1
公开(公告)日：2022-01-13
申请号：US17490215
申请日：2021-09-30
Applicant: Codexis, Inc.
Inventor： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark A. Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay H. Russell , Keith A. Canada
IPC: C12N15/63
Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20200010834A1
公开(公告)日：2020-01-09
申请号：US16460025
申请日：2019-07-02
Applicant: Codexis, Inc.
Inventor： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay Russell , Keith A. Canada
IPC: C12N15/63
Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20230159904A1
公开(公告)日：2023-05-25
申请号：US17916510
申请日：2021-04-06
Applicant: Codexis, Inc
Inventor： Rama Voladri , Jessica Anna Hurtak , Auric Anthony Sowell-Kantz , Nandhitha Subramanian , Ericka Bermudez , David Entwistle , Melissa Ann Mayo , James Nicholas Riggins
IPC: C12N9/18
CPC classification number: C12N9/18
Abstract: The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in hydrolysis reactions.
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公开(公告)号：US20220290110A1
公开(公告)日：2022-09-15
申请号：US17635163
申请日：2020-09-03
Applicant: Codexis, Inc.
Inventor： Da Duan , Auric Anthony Sowell-Kantz , Aksiniya Lyubenova Petkova , Jovana Nazor , Nandhitha Subramanian , Oscar Alvizo
IPC: C12N9/08
Abstract: The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing peroxidase enzymes are also provided. The present invention further provides compositions comprising the peroxidase enzymes and methods of using the engineered peroxidase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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