公开(公告)号：US20220091101A1

公开(公告)日：2022-03-24

申请号：US17309896

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille ZENOBIA ,  Harsh TRIVEDI ,  Ying YANG ,  Carlo DAEP ,  James MASTERS

IPC: G01N33/50 ,  C12N1/20 ,  G09B23/30

Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

公开(公告)号：US20220395441A1

公开(公告)日：2022-12-15

申请号：US17250564

申请日：2020-12-17

Applicant: Colgate-Palmolive Company ,  The University of North Carolina at Chapel Hill

Inventor： Payal Arora ,  Zhigang HAO ,  Paul THOMSON ,  Manish MANDHARE ,  Yu WANG ,  Chi-Yuan CHENG ,  Harsh TRIVEDI ,  Long PAN ,  Silvana BARROS

IPC: A61K8/35 ,  A61Q11/00 ,  A61K8/9794 ,  A61K8/37 ,  A61K8/19 ,  A61K8/25

Abstract: Described herein are methods for improving or maintaining the barrier integrity of gingival tissue comprising administering an oral care composition comprising a curcurninoid, to the oral cavity of a subject in need thereof.

公开(公告)号：US20170152272A1

公开(公告)日：2017-06-01

申请号：US15319423

申请日：2014-06-18

Applicant: Colgate-Palmolive Company

Inventor： Michael FITZGERALD ,  Joseph CONVERY ,  Harsh TRIVEDI ,  Lisa MANUS

IPC: C07F3/06

CPC classification number: C07F3/06 ,  C07B2200/13 ,  C07F3/003

Abstract: The disclosure provides an improved synthesis for a zinc-lysine complex having the formula [Zn(C6H14N2O2)2Cl]+Cl −, in which a zinc compound selected from ZnO and ZnCl2, is reacted with a lysine compound selected from lysine and lysineHCl, in aqueous acid. The disclosure also provides oral care and personal care compositions comprising the complex prepared by the synthesis, and methods of using these complexes and compositions.