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公开(公告)号：US11630109B2
公开(公告)日：2023-04-18
申请号：US17237464
申请日：2021-04-22
发明人： Robert E. Cohen , Yun-Seok Choi
IPC分类号： G01N33/68 , C07K14/435 , C07K14/47 , C12N9/48
摘要： The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
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公开(公告)号：US11016097B2
公开(公告)日：2021-05-25
申请号：US16251871
申请日：2019-01-18
发明人： Robert E. Cohen , Yun-Seok Choi
IPC分类号： G01N33/68 , C07K14/435 , C07K14/47 , C12N9/48
摘要： The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
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公开(公告)号：US10234459B2
公开(公告)日：2019-03-19
申请号：US15977727
申请日：2018-05-11
发明人： Robert E. Cohen , Yun-Seok Choi
IPC分类号： C12N9/48 , C07K14/47 , G01N33/68 , C07K14/435
摘要： The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
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公开(公告)号：US10018634B2
公开(公告)日：2018-07-10
申请号：US14266502
申请日：2014-04-30
发明人： Robert E. Cohen , Yun-Seok Choi
IPC分类号： G01N33/68 , C07K14/435 , C12N9/48 , C07K14/47
摘要： The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
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5.发明申请公开(公告)号：US20140322725A1
公开(公告)日：2014-10-30
申请号：US14266502
申请日：2014-04-30
发明人： Robert E. Cohen , Yun-Seok Choi
IPC分类号： G01N33/573 , G01N33/50 , C12N9/48 , C07K14/435 , G01N33/68
CPC分类号： G01N33/6842 , C07K14/435 , C07K14/47 , C07K2319/00 , C07K2319/70 , C12N9/485 , C12Y304/19012 , G01N33/6872
摘要： The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
摘要翻译： 本发明提供包含结合游离泛素蛋白或游离泛素样蛋白的高亲和力的嵌合多肽的组合物，以及结合游离和缀合的泛素蛋白或游离和缀合的泛素样蛋白的嵌合多肽，以及 使用嵌合多肽确定各种类型样品中游离或总泛素或游离或总泛素样蛋白的量。
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公开(公告)号：US20180364250A1
公开(公告)日：2018-12-20
申请号：US15977727
申请日：2018-05-11
发明人： Robert E. Cohen , Yun-Seok Choi
IPC分类号： G01N33/68 , C07K14/47 , C12N9/48 , C07K14/435
CPC分类号： G01N33/6842 , C07K14/435 , C07K14/47 , C07K2319/00 , C07K2319/70 , C12N9/485 , C12Y304/19012 , G01N33/6872
摘要： The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or toal ubiquitin or free or total ubiquitin-like proteins in various types of samples.
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