公开(公告)号：US20230348674A1

公开(公告)日：2023-11-02

申请号：US18012815

申请日：2021-06-24

Applicant: Commonwealth Scientific and Industrial Research Organisation

Inventor： Anh Tuan Nguyen ,  Johan Basuki ,  Timothy Hughes

IPC: C08J3/075 ,  A61K9/06 ,  A61K38/38 ,  A61K47/36 ,  A61K47/34 ,  C08G73/02

CPC classification number: C08J3/075 ,  A61K9/06 ,  A61K38/385 ,  A61K47/34 ,  A61K47/36 ,  C08G73/0233 ,  C08G2210/00 ,  C08G2230/00 ,  C08J2379/02 ,  C08J2389/06

Abstract: Described herein is a method of preparing a thermoresponsive polymer biomacromolecule conjugate, the method comprising: preparing by living cationic ring opening polymerisation a thermoresponsive polymer selected from polyoxazoline, polyoxazine, or copolymer thereof, the so-formed thermoresponsive polymer having a living cation; and reacting the living cation with a nucleophilic functional group selected from carboxylate, amino, sulfate, sulfonate, phosphate, phosphonate and thiol of a biomacromolecule to conjugate the thermoresponsive polymer to the biomacromolecule; wherein in an aqueous liquid the so-formed thermoresponsive polymer biomacromolecule conjugate exhibits a gelation temperature and forms a hydrogel in that liquid above that gelation temperature.