公开(公告)号：US12070534B2

公开(公告)日：2024-08-27

申请号：US16717112

申请日：2019-12-17

申请人： Sofradim Production

发明人： Nicolas Prost ,  Delphine Petit ,  Xavier Bourges

IPC分类号： A61L31/04 ,  A61F2/00 ,  A61L27/34 ,  A61L27/58 ,  A61L31/10 ,  A61L31/14 ,  B29C41/02 ,  B29C41/12 ,  B29C41/22 ,  B29C41/24 ,  C08J5/18 ,  C08J7/04 ,  C08L89/06

CPC分类号： A61L31/044 ,  A61F2/0063 ,  A61F2/0077 ,  A61L27/34 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  C08J5/18 ,  C08J7/0427 ,  C08L89/06 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2420/08 ,  B29C41/02 ,  B29C41/12 ,  B29C41/22 ,  B29C41/24 ,  C08J2389/06 ,  C08J2489/06 ,  A61L31/10 ,  C08L89/06

摘要： The present invention relates to a surgical anti-adhesion barrier film comprising an oxidized collagen and a polyphosphate compound and to a surgical implant comprising a prosthetic fabric and such a film.

公开(公告)号：US11746232B2

公开(公告)日：2023-09-05

申请号：US17498181

申请日：2021-10-11

申请人： Na Xu ,  Yanmei Xing ,  Xuechuan Wang

发明人： Na Xu ,  Yanmei Xing ,  Xuechuan Wang

IPC分类号： C08L77/00 ,  C08J3/24 ,  C08L89/06 ,  D06M10/00 ,  D06M13/127 ,  D06M13/507 ,  D06M15/15 ,  D06M101/34

CPC分类号： C08L77/00 ,  C08J3/247 ,  C08L89/06 ,  D06M10/001 ,  D06M13/127 ,  D06M13/507 ,  D06M15/15 ,  C08J2389/06 ,  C08L2205/16 ,  C08L2205/18 ,  C08L2312/00 ,  D06M2101/34 ,  D06M2400/01

摘要： A method of preparing a vinyl collagen microsphere polyamide fiber composite material includes the following steps: step 1: modifying a collagen with methacrylic anhydride to obtain a vinyl collagen, then emulsifying and cross-linking the vinyl collagen to obtain vinyl collagen microspheres; step 2: treating a polyamide fiber substrate with formaldehyde to obtain a hydroxylated polyamide fiber substrate, treating the hydroxylated polyamide fiber with (3-mercaptopropyl)trimethoxysilane (MPS) to obtain a sulfhydrylated polyamide fiber substrate; and step 3: modifying the sulfhydrylated polyamide fiber substrate with the vinyl collagen microspheres to obtain the vinyl collagen microsphere polyamide fiber composite material.

公开(公告)号：US20170233944A1

公开(公告)日：2017-08-17

申请号：US15433566

申请日：2017-02-15

申请人： MODERN MEADOW, INC.

发明人： Brendan Patrick PURCELL ,  David Thomas WILLIAMSON ,  Lixin DAI ,  Darryl Miles CASSINGHAM ,  Stephen M. SPINELLA ,  Amy CONGDON

IPC分类号： D06N3/00

CPC分类号： C08J3/24 ,  B32B1/08 ,  B32B3/266 ,  B32B5/022 ,  B32B5/024 ,  B32B5/026 ,  B32B5/26 ,  B32B7/12 ,  B32B9/025 ,  B32B15/02 ,  B32B15/14 ,  B32B23/10 ,  B32B27/12 ,  B32B29/02 ,  B32B2250/02 ,  B32B2250/03 ,  B32B2250/20 ,  B32B2250/40 ,  B32B2250/42 ,  B32B2255/02 ,  B32B2255/26 ,  B32B2262/0207 ,  B32B2262/0261 ,  B32B2262/0269 ,  B32B2262/0276 ,  B32B2262/0292 ,  B32B2262/04 ,  B32B2262/062 ,  B32B2262/065 ,  B32B2262/067 ,  B32B2262/08 ,  B32B2262/10 ,  B32B2262/101 ,  B32B2262/103 ,  B32B2262/106 ,  B32B2262/14 ,  B32B2264/105 ,  B32B2307/202 ,  B32B2307/208 ,  B32B2307/308 ,  B32B2307/4026 ,  B32B2307/422 ,  B32B2307/50 ,  B32B2307/51 ,  B32B2307/54 ,  B32B2307/5825 ,  B32B2307/708 ,  B32B2307/7265 ,  B32B2437/00 ,  B32B2437/02 ,  B32B2437/04 ,  B32B2439/46 ,  B32B2451/00 ,  B32B2457/00 ,  B32B2471/00 ,  B32B2479/00 ,  B32B2519/00 ,  B32B2571/00 ,  B32B2601/00 ,  B32B2605/003 ,  B32B2605/08 ,  B32B2605/12 ,  B32B2605/18 ,  C07K14/78 ,  C08J2389/06 ,  C14C9/00 ,  C14C9/02 ,  C14C13/00 ,  D01C3/00 ,  D01F4/00 ,  D04H1/00 ,  D04H1/4382 ,  D04H13/00 ,  D06M15/05 ,  D06M15/15 ,  D06M23/16 ,  D06M2101/06 ,  D06N3/00 ,  D06N3/0018 ,  D06N7/0097 ,  D06N2201/06 ,  D06N2203/02 ,  D06P3/32

摘要： A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).

公开(公告)号：US20170233836A1

公开(公告)日：2017-08-17

申请号：US15433225

申请日：2017-02-15

申请人： Karoly Robert JAKAB ,  Brendan Patrick PURCELL ,  David WILLIAMSON ,  Francoise Suzanne MARGA

发明人： Karoly Robert JAKAB ,  Brendan Patrick PURCELL ,  David WILLIAMSON ,  Francoise Suzanne MARGA

IPC分类号： C14C13/00 ,  D04H1/728 ,  C08J3/24 ,  D02J1/04 ,  C14C9/02 ,  D06P3/32

CPC分类号： C14C13/00 ,  C08H1/06 ,  C08J3/24 ,  C08J2389/06 ,  C08L89/06 ,  C14C9/02 ,  D01D5/003 ,  D01D5/0053 ,  D01F4/00 ,  D02J1/04 ,  D04H1/728 ,  D06B19/007 ,  D06M10/00 ,  D06N3/0018 ,  D06P3/32

摘要： Biofabricated leathers made by electrocompaction and/or electrospsinning. Described herein are biofabricated leather materials derived from electrospun or electrocompacted collagen networks. These electrospun or electrocompacted leathers may have leather-like properties following and are may be processed as native leather and used to form leather goods.

公开(公告)号：US09629939B2

公开(公告)日：2017-04-25

申请号：US14403396

申请日：2013-05-16

申请人： Queen's University at Kingston

发明人： Lauren E. Flynn ,  Claire Yu

IPC分类号： A61L27/24 ,  A61L27/26 ,  A61L27/38 ,  A61L27/56 ,  A61L27/54 ,  B32B5/32 ,  C08J9/228 ,  C08L89/06 ,  C08H1/06 ,  A61L27/36 ,  C08J9/28

CPC分类号： A61L27/24 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/64 ,  A61L2430/34 ,  B32B5/32 ,  C08H1/06 ,  C08J9/228 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2389/06 ,  C08L89/06

摘要： Provided is a foam material, comprising a plurality of substantially collagenous beads, wherein the foam material is a bead foam, and wherein adjacent collagenous beads are fused together by a network of collagen fibers. Also provided are methods for preparation of foam materials comprising a plurality of substantially collagenous beads. The foam materials may be used in applications such as bioscaffolds for wound healing, soft tissue regeneration and augmentation, for localized cell delivery, or as cell culture substrates for research. The foam materials include natural collagen fibrils that provide a stable scaffold and enhance integration of the implanted scaffold and regeneration of cells and tissue.

公开(公告)号：US20150272729A1

公开(公告)日：2015-10-01

申请号：US14438142

申请日：2013-10-25

申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES

发明人： William D. Wagner ,  Levi-Polyachenko Nicole ,  Rui Wang ,  Louis C. Argenta ,  Michael J. Morykwas

IPC分类号： A61F2/24 ,  C08L89/00 ,  C08L89/06 ,  A61F2/82 ,  C08J9/00

CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/82 ,  A61K9/70 ,  A61L27/26 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2430/20 ,  C08J9/0061 ,  C08J2389/00 ,  C08J2389/06 ,  C08J2467/02 ,  C08J2489/00 ,  C08J2489/06 ,  C08L89/00 ,  C08L89/06 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2203/12 ,  C08L2205/02 ,  C08L2205/03 ,  Y10T428/298 ,  C08L31/06

摘要： Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.

摘要翻译： 含有丝素蛋白用于伤口修复和组织置换的纳米纤维生物材料，更具体地说，是心脏瓣膜置换。

公开(公告)号：US20060135921A1

公开(公告)日：2006-06-22

申请号：US10552038

申请日：2004-04-05

申请人： Robert Wiercinski ,  Roy Pang ,  Dona Hevroni

发明人： Robert Wiercinski ,  Roy Pang ,  Dona Hevroni

IPC分类号： B32B3/26 ,  A61F13/15

CPC分类号： C08J3/12 ,  A61K8/0208 ,  A61K8/65 ,  A61L27/24 ,  A61L27/56 ,  A61Q19/00 ,  C08H1/06 ,  C08J2389/06 ,  C08L89/06 ,  C12N5/0068 ,  C12N5/0075 ,  C12N2533/54 ,  Y10T428/249953

摘要： The present invention relates to the development of new porous particulate collagen sponges, combining the desirable features of low toxicity, resorbability, and satisfactory porosity, particularly when wetted in an aqueous medium. Accordingly, the present invention is directed to new porous, particulate, dehydrothermally cross-linked, wetted sponges, as well as a process for making them.

摘要翻译： 本发明涉及新型多孔微粒胶原海绵的开发，结合​​低毒性，再吸收性和令人满意的孔隙率的理想特征，特别是在水性介质中润湿时。 因此，本发明涉及新的多孔，微粒，脱水热交联的湿润海绵，以及它们的制备方法。

公开(公告)号：US5457136A

公开(公告)日：1995-10-10

申请号：US288616

申请日：1994-08-10

申请人： G. Robert Hartranft ,  Ronald S. Lenox ,  Dean L. Putt ,  Joseph F. Remar ,  Donald M. Snyder

发明人： G. Robert Hartranft ,  Ronald S. Lenox ,  Dean L. Putt ,  Joseph F. Remar ,  Donald M. Snyder

IPC分类号： C08J9/00

CPC分类号： C08J9/0023 ,  C08J2389/06

摘要： Thermal insulation is prepared using gelatin foam. Embodiments of gelatin foam insulation which are described include gelatin foam having an anti-wicking agent which is an aromatic compound having as ring substituents: an --NH.sub.2 moiety and/or a hydroxyl moiety and also at least two sulfonate moieties. In another embodiment, the gelatin foam is combined with phyllosilicate mineral lamellae for void control and as a shrinkage deterrent. In yet another embodiment, crosslinked gelatin foam is described which has been crosslinked with a melamine/formaldehyde condensation product, a polyfunctional aziridine and/or an epichlorohydrin/polyamide condensation product.

摘要翻译： 使用明胶泡沫制备绝热。 描述的明胶泡沫绝缘体的实施方案包括具有抗毛细作用剂的明胶泡沫，其为具有环取代基的芳族化合物：-NH 2部分和/或羟基部分以及至少两个磺酸盐部分。 在另一个实施方案中，将明胶泡沫与页硅酸盐矿物薄片组合以进行空隙控制和抑制收缩。 在另一个实施方案中，描述了已经与三聚氰胺/甲醛缩合产物，多官能氮丙啶和/或表氯醇/聚酰胺缩合产物交联的交联明胶泡沫。

公开(公告)号：US5225536A

公开(公告)日：1993-07-06

申请号：US550893

申请日：1990-07-11

申请人： Sadao Nishibori

发明人： Sadao Nishibori

IPC分类号： C08J3/12 ,  C08J9/28 ,  C08L75/04 ,  C09D189/06 ,  C09H9/04 ,  D06M13/342 ,  D06M15/15 ,  D06M23/08

CPC分类号： C08J3/12 ,  C08J3/122 ,  C08J9/28 ,  C08L75/04 ,  C09D189/06 ,  C09H9/04 ,  D06M13/342 ,  D06M15/15 ,  D06M23/08 ,  C08J2375/04 ,  C08J2389/06

摘要： Fine particles of gelatin and amino acid used in the present invention are particularly suitable for use in combination with resins.Gelatin particles used in the present invention have the number-average molecular weight of 8,500 or less, and amino acid particles with the number-average molecular weight of 200 or less, so that efficient pulverization becomes possible and that gelatin and amino acid particles maintain their intrinsic properties as they are not subject to denaturation during pulverization. Resultant particles are neither too large nor too small but are uniform in size and are particularly suitable for use in combination with resins.

公开(公告)号：US5100707A

公开(公告)日：1992-03-31

申请号：US608689

申请日：1990-11-05

申请人： Sadao Nishibori

发明人： Sadao Nishibori

IPC分类号： C14B3/00 ,  C08J3/12 ,  C08L89/06

CPC分类号： C08J3/12 ,  C08J3/122 ,  C08L89/06 ,  C08J2389/06 ,  Y10S264/913 ,  Y10T428/2982 ,  Y10T428/4935

摘要： The present invention relates to methods, compositions, and articles manufactured from scrap treated skin and/or leather which has been finely pulverized and mixed with synthetic resin. It further includes a method for the manufacture of improved leather products made from animal skin and/or leather and/or animal gelatin including the products derived therefrom and the method of producing skin and/or leather powder by use of steam and pulverization for combining with a fluid plastic material or resin in which the powder is uniformally dispersed in the plastic resin material for molding, extruding or manufacture of sheet material or for incorporation into coatings, paint or other plastic resinous products.