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    Therapeutic application of Kazal-type serine protease inhibitors
    3.
    发明授权
    Therapeutic application of Kazal-type serine protease inhibitors 有权
    Kazal型丝氨酸蛋白酶抑制剂的治疗应用

    公开(公告)号：US08283319B2

    公开(公告)日：2012-10-09

    申请号：US12526758

    申请日：2008-02-11

    申请人： Stefan Schulte ,  Ulrich Kronthaler ,  Stefan Schmidbauer ,  Thomas Weimer ,  Kay Hofmann

    发明人： Stefan Schulte ,  Ulrich Kronthaler ,  Stefan Schmidbauer ,  Thomas Weimer ,  Kay Hofmann

    IPC分类号： A61K38/16 ,  C07K14/00

    CPC分类号： C07K14/8135 ,  A61K38/00 ,  A61K47/64 ,  A61K47/643

    摘要： The present invention relates to the therapeutic application of the Kazal-type serine protease inhibitor Infestin or domains thereof or modified Kazal-type serine protease inhibitors based on Infestin homologs, which prevent the formation and/or stabilization of three-dimensional arterial or venous thrombi by interfering with proteins involved in activation of the so-called intrinsic coagulation pathway. The present invention also relates to the use of Kazal-type serine protease inhibitors or fragments thereof or modified Kazal-type serine protease inhibitors in the treatment or prophylaxis of a condition or disorder related to arterial thrombus formation, i.e. stroke or myocardial infarction, inflammation, complement activation, fibrinolysis, angiogenesis and/or diseases linked to pathological kinin formation such as hypotonic shock, edema including hereditary angioedema, bacterial infections, arthritis, pancreatitis, or articular gout, Disseminated Intravasal Coagulation (DIC) and sepsis.

    摘要翻译： 本发明涉及基于Infestin同系物的Kazal型丝氨酸蛋白酶抑制剂Infestin或其结构域或修饰的Kazal型丝氨酸蛋白酶抑制剂的治疗应用，其防止三维动脉或静脉血栓的形成和/或稳定化 干扰参与所谓的内在凝血途径活化的蛋白质。 本发明还涉及Kazal型丝氨酸蛋白酶抑制剂或其片段或修饰的Kazal型丝氨酸蛋白酶抑制剂在治疗或预防与动脉血栓形成有关的病症或障碍的应用，即中风或心肌梗塞，炎症， 补体活化，纤维蛋白溶解，血管发生和/或与病理激肽形成相关的疾病，如低渗休克，水肿，包括遗传性血管性水肿，细菌感染，关节炎，胰腺炎或关节痛风，弥散性内皮内凝血（DIC）和败血症。

    Method for purifying enzymes from clostridium histolyticum using multi-stage chromatography
    4.
    发明授权
    Method for purifying enzymes from clostridium histolyticum using multi-stage chromatography 有权
    使用多级色谱法纯化溶组织梭菌的酶的方法

    公开(公告)号：US07083964B2

    公开(公告)日：2006-08-01

    申请号：US10478545

    申请日：2002-06-01

    申请人： Manfred Kurfürst ,  Stefan Schmidbauer

    发明人： Manfred Kurfürst ,  Stefan Schmidbauer

    IPC分类号： C12N9/48

    CPC分类号： C12N9/52 ,  C12Y304/22008

    摘要： The invention relates to a method for purifying at least one enzyme obtained in an excess fermentation of Clostridium histolyticum. It is provided for that the enzymes of the excess fermentation are separated by a multistage chromatography method by exclusively using chromatography materials on styrene/divinyl-benzene base and/or on base of in particular ceramic hydroxylapatite.

    摘要翻译： 本发明涉及一种纯化至少一种在溶组织梭菌过量发酵中获得的酶的方法。 提供了通过专门使用苯乙烯/二乙烯基 - 苯基和/或特别是陶瓷羟基磷灰石的基础上的色谱材料的多层色谱法分离过量发酵的酶。

    THERAPEUTIC APPLICATION OF KAZAL-TYPE SERINE PROTEASE INHIBITORS
    5.
    发明申请
    THERAPEUTIC APPLICATION OF KAZAL-TYPE SERINE PROTEASE INHIBITORS 有权
    卡氏型丝氨酸蛋白酶抑制剂的治疗应用

    公开(公告)号：US20100279923A1

    公开(公告)日：2010-11-04

    申请号：US12526758

    申请日：2008-02-11

    申请人： Stefan Schulte ,  Ulrich Kronthaler ,  Stefan Schmidbauer ,  Thomas Weimer ,  Kay Hofmann

    发明人： Stefan Schulte ,  Ulrich Kronthaler ,  Stefan Schmidbauer ,  Thomas Weimer ,  Kay Hofmann

    IPC分类号： A61K38/55 ,  C07K14/00 ,  C07K14/76 ,  C07K16/00 ,  A61P5/00 ,  A61P35/00 ,  A61P9/00 ,  A61P9/10 ,  C12P21/06

    CPC分类号： C07K14/8135 ,  A61K38/00 ,  A61K47/64 ,  A61K47/643

    摘要： The subject of the present invention is, in the most general aspect, the therapeutic application of the Kazal-type serine protease inhibitor Infestin or domains thereof or modified Kazal-type serine protease inhibitors based on Infestin homologs, which prevent the formation and/or stabilization of three-dimensional arterial or venous thrombi by interfering with proteins involved in activation of the so-called intrinsic coagulation pathway. In particular the present invention relates to the use of said Kazal-type serine protease inhibitors or fragments thereof or modified Kazal-type serine protease inhibitors, in the treatment or prophylaxis of a condition or disorder related to arterial thrombus formation, i. e. stroke or myocardial infarction, inflammation, complement activation, fibrinolysis, angiogenesis and/or diseases linked to pathological kinin formation such as hypotonic shock, edema including hereditary angioedema, bacterial infections, arthritis, pancreatitis, or articular gout, Disseminated Intravasal Coagulation (DIC) and sepsis.

    摘要翻译： 本发明的主题在最一般的方面是基于Infestin同系物的Kazal型丝氨酸蛋白酶抑制剂Infestin或其结构域或修饰的Kazal型丝氨酸蛋白酶抑制剂的治疗应用，其防止形成和/或稳定化 通过干扰参与所谓的内在凝血途径的激活的蛋白质的三维动脉或静脉血栓。 特别地，本发明涉及所述Kazal型丝氨酸蛋白酶抑制剂或其片段或修饰的Kazal型丝氨酸蛋白酶抑制剂在治疗或预防与动脉血栓形成相关的病症或障碍中的用途， e。 中风或心肌梗塞，炎症，补体激活，纤维蛋白溶解，血管生成和/或与病理激肽形成相关的疾病，例如低渗休克，包括遗传性血管性水肿，细菌感染，关节炎，胰腺炎或关节痛风的水肿，弥散性内皮内凝血（DIC）和 败血症