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    Pharmaceutical compounds
    1.
    发明授权
    Pharmaceutical compounds 失效
    药物化合物

    公开(公告)号：US5990165A

    公开(公告)日：1999-11-23

    申请号：US46445

    申请日：1998-03-24

    申请人： Concepcion Pedregal Tercero ,  Almudena Rubio Esteban

    发明人： Concepcion Pedregal Tercero ,  Almudena Rubio Esteban

    IPC分类号： A61K31/195 ,  A61K31/215 ,  A61P25/26 ,  C07C227/22 ,  C07C229/30 ,  C07C229/32 ,  C07C229/36 ,  C07C323/58

    CPC分类号： C07C229/30 ,  C07C2101/08 ,  C07C2101/14 ,  Y02P20/55

    摘要： A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R.sup.1 is --CO.sub.2 H, R.sup.2 is hydrogen or C.sub.1-4 alkyl andR.sup.3 is hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C.sub.1-4 alkyl, optionally substituted phenyl C.sub.2-10 alkenyl,(optionally substituted phenyl).sub.2 -C.sub.1-4 alkyl, optionally substituted C.sub.3-7 cycloalkyl, optionally substituted C.sub.3-7 cycloalkyl-C.sub.1-4 alkyl or optionally substituted C.sub.3-7 cycloalkyl-C.sub.2-10 alkenyl, orR.sup.2 and R.sup.3, together with the carbon atom to which they are attached, form an optionally substituted C.sub.4-7 cycloalkyl group;or a salt or ester thereof other than the compounds .gamma.-propylidene-L-glutamic acid, .gamma.-ethylidene-L-glutamic acid and .gamma.-methylidene-L-glutamic acid.

    摘要翻译： 下式的药物化合物：其中n为1或2，R 1为-CO 2 H，R 2为氢或C 1-4烷基，R 3为氢，C 1-10烷基，C 2-10烯基，任选取代的苯基，任选取代的苯基 -C 1-4烷基，任选取代的苯基C 2-10烯基，（任选取代的苯基）2 -C 1-4烷基，任选取代的C 3-7环烷基，任选取代的C 3-7环烷基-C 1-4烷基或任选取代的C 3-7 环烷基-C 2-10烯基，或者R 2和R 3与它们所连接的碳原子一起形成任选取代的C 4-7环烷基; 或其除了γ-亚丙基-L-谷氨酸，γ-亚乙基-L-谷氨酸和γ-亚甲基-L-谷氨酸的化合物的盐或酯。