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公开(公告)号:US07335660B2
公开(公告)日:2008-02-26
申请号:US10496535
申请日:2002-12-06
申请人: Javier Agejas-Chicharro , Graham Henry Timms , Andrew Caerwyn Williams , Nicholas Paul Camp , Jeremy Gilmore , Ana Belen Bueno Melendo , Carlos Lamas-Peteira
发明人: Javier Agejas-Chicharro , Graham Henry Timms , Andrew Caerwyn Williams , Nicholas Paul Camp , Jeremy Gilmore , Ana Belen Bueno Melendo , Carlos Lamas-Peteira
IPC分类号: A61K31/496 , C07D311/76 , C07D405/06 , C07D409/12 , C07D413/12 , C07D413/06 , C07D413/14 , C07D413/04 , C07D407/06 , C07D409/14 , C07D405/04 , C07D417/12 , C07D405/12
CPC分类号: C07D405/06 , C07D307/87 , C07D311/76 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要: This invention relates to compounds of formula (I) where R1 to R12, —W—V—, —X—Y—, p and n have the values defined in claim 1, their preparation and use as pharmaceuticals for the treatment of central nervous system disorders, such as depression, bipolar disorder, and anxiety.
摘要翻译: 本发明涉及其中R 1至R 12,-WV-,-XY-,p和n具有权利要求1中定义的值的式(I)化合物, 其制备和用作药物用于治疗中枢神经系统疾病,例如抑郁症,双相性精神障碍和焦虑症。
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公开(公告)号:US07354920B2
公开(公告)日:2008-04-08
申请号:US10524921
申请日:2003-08-18
申请人: Manuel Javier Cases-Thomas , Helen Louise Haughton , Robin George Simmonds , Hélène Catherine Eugénie Rudyk , Magnus Wilhelm Walter , Sivi Ouwerkerk-Mahadevan , John Joseph Masters , Carlos Lamas-Peteira
发明人: Manuel Javier Cases-Thomas , Helen Louise Haughton , Robin George Simmonds , Hélène Catherine Eugénie Rudyk , Magnus Wilhelm Walter , Sivi Ouwerkerk-Mahadevan , John Joseph Masters , Carlos Lamas-Peteira
IPC分类号: A61K31/5375 , C07D265/30
CPC分类号: C07D265/30 , C07D413/10
摘要: Compounds of formula (I) wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C1-C4 alkyl; and Ar1 and Ar2 are optionally substituted phenyl or 5- or 6-membered heteroaryl rings are selective inhibitors of the reuptake of norepinephrine.
摘要翻译: 其中Rx是H的式(I)化合物; R y为H或C 1 -C 4烷基; 每个R z独立地为H或C 1 -C 4烷基; X表示O; Y表示OH或OR; R是C 1 -C 4烷基; 和Ar 1和Ar 2是任选取代的苯基或5-或6-元杂芳环是去甲肾上腺素再摄取的选择性抑制剂。
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公开(公告)号:US20070060585A1
公开(公告)日:2007-03-15
申请号:US10575469
申请日:2004-12-10
IPC分类号: A61K31/5377 , A61K31/5375 , C07D413/02
CPC分类号: C07D265/30 , C07D295/027 , C07D295/192 , C07D401/10
摘要: Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
摘要翻译: 通式(I)的化合物是去甲肾上腺素再摄取的抑制剂。 因此,它们可用于治疗中枢和/或周围神经系统的病症。
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公开(公告)号:US5861408A
公开(公告)日:1999-01-19
申请号:US835452
申请日:1997-04-08
申请人: James E. Audia , Stephen Richard Baker , Jesus Ezquerra Carrera , Carlos Lamas Peteira , Concepcion Pedregal Tercero
发明人: James E. Audia , Stephen Richard Baker , Jesus Ezquerra Carrera , Carlos Lamas Peteira , Concepcion Pedregal Tercero
IPC分类号: C07D471/04 , A61K31/44 , C07D471/10
CPC分类号: C07D471/04
摘要: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.
摘要翻译: 本发明提供具有有用的中枢神经系统活性的新颖的四氢-β-咔啉化合物。 此外,提供了四氢-β-咔啉相关化合物,其是有用的中间体并具有有益的中枢神经系统活性。 本发明提供了使用新型四氢-β-咔啉及相关化合物的配方和方法。 这些化合物特别可用于5-HT 2B受体的调节。
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5.
公开(公告)号:US08778946B2
公开(公告)日:2014-07-15
申请号:US13882765
申请日:2011-11-17
IPC分类号: C07D471/04 , A61K31/496 , C07D487/04
CPC分类号: C07D487/04 , C07D471/04
摘要: The invention provides certain 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds, particularly compounds of formula I and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat Parkinsons disease Formula (I).
摘要翻译: 本发明提供某些3-取代-6-(吡啶基甲氧基) - 吡咯并吡啶化合物,特别是式I化合物及其药物组合物。 本发明进一步提供使用式I化合物治疗帕金森病公式(I)的方法。
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6.
公开(公告)号:US20130225602A1
公开(公告)日:2013-08-29
申请号:US13882765
申请日:2011-11-17
IPC分类号: C07D487/04
CPC分类号: C07D487/04 , C07D471/04
摘要: The invention provides certain 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds, particularly compounds of formula I and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat Parkinsons disease Formula (I).
摘要翻译: 本发明提供某些3-取代-6-(吡啶基甲氧基) - 吡咯并吡啶化合物,特别是式I化合物及其药物组合物。 本发明进一步提供使用式I化合物治疗帕金森病公式(I)的方法。
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公开(公告)号:US07595315B2
公开(公告)日:2009-09-29
申请号:US10575469
申请日:2004-12-10
IPC分类号: A61K31/5375 , C07D265/30
CPC分类号: C07D265/30 , C07D295/027 , C07D295/192 , C07D401/10
摘要: Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
摘要翻译: 通式(I)的化合物是去甲肾上腺素再摄取的抑制剂。 因此,它们可用于治疗中枢和/或周围神经系统的病症。
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公开(公告)号:US5861409A
公开(公告)日:1999-01-19
申请号:US835774
申请日:1997-04-08
申请人: James E. Audia , Stephen Richard Baker , Jesus Ezquerra Carrera , Carlos Lamas Peteira , Concepcion Pedregal Tercero
发明人: James E. Audia , Stephen Richard Baker , Jesus Ezquerra Carrera , Carlos Lamas Peteira , Concepcion Pedregal Tercero
IPC分类号: C07D471/04 , A61K31/44
CPC分类号: C07D471/04
摘要: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.
摘要翻译: 本发明提供具有有用的中枢神经系统活性的新颖的四氢-β-咔啉化合物。 此外,提供了四氢-β-咔啉相关化合物,其是有用的中间体并具有有益的中枢神经系统活性。 本发明提供了使用新型四氢-β-咔啉及相关化合物的配方和方法。 这些化合物特别可用于5-HT 2B受体的调节。
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公开(公告)号:US06846830B2
公开(公告)日:2005-01-25
申请号:US10221822
申请日:2001-03-19
IPC分类号: A61K31/095 , A61K31/235 , A61K31/277 , A61K31/424 , A61K31/426 , A61K31/44 , A61K31/4409 , A61K31/505 , A61P25/08 , A61P43/00 , C07D213/06 , C07D213/127 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/32 , C07D213/57 , C07D213/61 , C07D213/68 , C07D239/26 , C07D277/24 , C07D213/02 , A61K31/445
CPC分类号: A61K31/095 , A61K31/235 , A61K31/277 , A61K31/426 , A61K31/44 , A61K31/4409 , A61K31/505 , C07D213/06 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/32 , C07D213/57 , C07D213/61 , C07D213/68 , C07D239/26 , C07D277/24
摘要: Use of compounds of the formula (I) where A, E, R1, R2, p and q have the meanings given in the specification are GluR6 antagonists useful for the treatment of disorders of the central nervous system.
摘要翻译: 其中A,E,R 1,R 2,p和q具有本说明书中给出的含义的式(I)化合物的用途是可用于治疗中枢神经系统疾病的GluR6拮抗剂。
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公开(公告)号:US5663178A
公开(公告)日:1997-09-02
申请号:US380565
申请日:1995-02-06
申请人: James E. Audia , Stephen Richard Baker , Jesus Ezquerra Carrera , Carlos Lamas Peteira , Concepcion Pedregal Tercero
发明人: James E. Audia , Stephen Richard Baker , Jesus Ezquerra Carrera , Carlos Lamas Peteira , Concepcion Pedregal Tercero
IPC分类号: A61K31/40 , A61K31/42 , A61K31/44 , A61K31/475 , A61K31/48 , A61K31/495 , A61K31/55 , C07D471/04
CPC分类号: C07D471/04 , A61K31/40 , A61K31/42 , A61K31/44 , A61K31/475 , A61K31/48 , A61K31/495 , A61K31/55
摘要: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.
摘要翻译: 本发明提供具有有用的中枢神经系统活性的新颖的四氢-β-咔啉化合物。 此外,提供了四氢-β-咔啉相关化合物,其是有用的中间体并具有有益的中枢神经系统活性。 本发明提供了使用新型四氢-β-咔啉及相关化合物的配方和方法。 这些化合物特别可用于5-HT 2B受体的调节。
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