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公开(公告)号：US20190100484A1
公开(公告)日：2019-04-04
申请号：US16055407
申请日：2018-08-06
IPC分类号： C07C59/115 , C07C69/708 , C07C69/675 , A61K45/06 , C07C69/67 , C07C59/01 , A61K31/19 , C07B59/00 , C07C59/125 , A61K31/225 , A61K31/22
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
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公开(公告)号：US10040748B2
公开(公告)日：2018-08-07
申请号：US15095545
申请日：2016-04-11
发明人： Roger D. Tung , Adam J. Morgan
IPC分类号： A61K31/19 , C07C59/01 , C07C59/115 , C07B59/00 , C07C69/67 , A61K31/22 , A61K31/225 , A61K45/06 , C07C59/125 , C07C69/675 , C07C69/708
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
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公开(公告)号：US09309182B2
公开(公告)日：2016-04-12
申请号：US14255331
申请日：2014-04-17
发明人： Roger D. Tung , Adam J. Morgan
IPC分类号： A61K31/19 , C07C59/01 , C07C59/125 , C07B59/00 , C07C69/67 , A61K31/22 , A61K31/225 , A61K45/06 , C07C69/675 , C07C69/708
CPC分类号： C07C59/115 , A61K31/19 , A61K31/22 , A61K31/225 , A61K45/06 , C07B59/001 , C07B2200/05 , C07C59/01 , C07C59/125 , C07C69/67 , C07C69/675 , C07C69/708
摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
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公开(公告)号：US09181192B2
公开(公告)日：2015-11-10
申请号：US14490787
申请日：2014-09-19
发明人： Adam J. Morgan
IPC分类号： A61K31/47 , C07D215/00 , C07D215/56
CPC分类号： C07D215/56 , C07B59/002 , C07B2200/05
摘要： This invention relates to compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a CFTR potentiator.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物以及这些组合物在治疗通过施用CFTR增效剂有益治疗的疾病和病症的方法中的用途。
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公开(公告)号：US20190225605A1
公开(公告)日：2019-07-25
申请号：US16189304
申请日：2018-11-13
发明人： Adam J. Morgan
IPC分类号： C07D471/04 , A61P35/00 , C07F9/06 , A61K31/519 , A61K31/675 , A61K45/06
摘要： This invention relates to novel pyrido[2,3-d]pyrimidinones of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a CDK-4 and/or CDK-6 inhibitor.
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公开(公告)号：US20170137383A1
公开(公告)日：2017-05-18
申请号：US15358407
申请日：2016-11-22
发明人： Adam J. Morgan
IPC分类号： C07D215/56 , C07B59/00
CPC分类号： C07D215/56 , C07B59/002 , C07B2200/05
摘要： This invention relates to compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a CFTR potentiator.
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公开(公告)号：US20170015670A1
公开(公告)日：2017-01-19
申请号：US15220642
申请日：2016-07-27
发明人： Roger D. Tung , Adam J. Morgan
IPC分类号： C07D487/04 , C07B59/00
CPC分类号： C07D487/04 , C07B59/002 , C07B2200/05
摘要： The present invention in one embodiment provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the specification.
摘要翻译： 或其药学上可接受的盐，其中式I所示的变量如说明书中所定义。
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公开(公告)号：US09422295B2
公开(公告)日：2016-08-23
申请号：US14418831
申请日：2013-07-30
发明人： Roger D. Tung , Adam J. Morgan
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07B59/00
CPC分类号： C07D487/04 , C07B59/002 , C07B2200/05
摘要： The present invention in one embodiment provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula (I) are as defined in the specification.
摘要翻译： 本发明在一个实施方案中提供式（I）的化合物; 或其药学上可接受的盐，其中式（I）所示的变量如说明书中所定义。
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公开(公告)号：US20150197525A1
公开(公告)日：2015-07-16
申请号：US14570954
申请日：2014-12-15
IPC分类号： C07D487/04 , A61K45/06 , A61K31/519
CPC分类号： A61K31/519 , A61K31/4045 , A61K31/454 , A61K31/5685 , A61K31/7068 , A61K45/06 , C07B2200/05 , C07D487/04 , A61K2300/00
摘要： The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.
摘要翻译： 本发明在一个实施方案中提供式A化合物或其药学上可接受的盐; 包含该化合物的药物组合物; 以及治疗本文公开的适应症的方法。
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公开(公告)号：US20220306636A1
公开(公告)日：2022-09-29
申请号：US17428850
申请日：2020-02-06
发明人： Robert S. Lewis , Mahender Reddy Karla , Kathryn E. Kavouris , Yong Dong , Adam J. Morgan , Cameron J. Cowden
IPC分类号： C07D487/04 , C07D403/04 , C07C309/65 , C07B59/00
摘要： Improved processes and intermediates for preparing ruxolitinib and deuterated analogs of ruxolitinib are disclosed.
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