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69 条记录 (耗时 0.035 秒)

    Substituted xanthine derivatives
    4.
    发明授权
    Substituted xanthine derivatives 有权

    公开(公告)号：US09918987B2

    公开(公告)日：2018-03-20

    申请号：US15291764

    申请日：2016-10-12

    申请人： Concert Pharmaceuticals, Inc.

    发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

    IPC分类号： A61K31/522 ,  C07D473/06

    CPC分类号： A61K31/522 ,  C07D473/06

    摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

    Morphinan Compounds
    6.
    发明申请
    Morphinan Compounds 有权
    吗啡化合物

    公开(公告)号：US20170037449A1

    公开(公告)日：2017-02-09

    申请号：US15068404

    申请日：2016-03-11

    申请人： Concert Pharmaceuticals, Inc.

    发明人： Roger D. Tung

    IPC分类号： C12Q1/28 ,  G01N33/49 ,  C07D221/28 ,  G01N33/493

    CPC分类号： C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/002 ,  C07D221/28 ,  C07D471/08 ,  G01N33/491 ,  G01N33/493

    摘要： This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.

    摘要翻译： 本公开涉及新的吗啡喃化合物及其衍生物，其药学上可接受的盐，溶剂合物和水合物。 本公开还提供了包含本公开的化合物的组合物以及该组合物在治疗通过施用还具有NMDA拮抗剂活性的σ1受体激动剂有益治疗的疾病和病症的方法中的用途。

    SUBSTITUTED XANTHINE DERIVATIVES
    7.
    发明申请
    SUBSTITUTED XANTHINE DERIVATIVES 有权
    取代的XANTHINE衍生物

    公开(公告)号：US20170027946A1

    公开(公告)日：2017-02-02

    申请号：US15291764

    申请日：2016-10-12

    申请人： Concert Pharmaceuticals, Inc.

    发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

    IPC分类号： A61K31/522

    CPC分类号： A61K31/522 ,  C07D473/06

    摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

    摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如，本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。

    Inhibitors of cholesterol ester transfer protein
    10.
    发明授权
    Inhibitors of cholesterol ester transfer protein 有权
    胆固醇酯转运蛋白抑制剂

    公开(公告)号：US09233938B2

    公开(公告)日：2016-01-12

    申请号：US14271114

    申请日：2014-05-06

    申请人： Concert Pharmaceuticals, Inc.

    发明人： Roger D. Tung

    IPC分类号： A61K31/421 ,  C07D263/04 ,  C07D263/20 ,  A61K31/40

    CPC分类号： C07D263/20 ,  A61K31/40 ,  A61K31/421 ,  C07B2200/05

    摘要： The invention relates to novel oxazolidinones their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering cholesterol ester transfer protein inhibitors.

    摘要翻译： 本发明涉及新型恶唑烷酮衍生物，其药学上可接受的盐，溶剂化物和水合物。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用胆固醇酯转移蛋白抑制剂有益治疗的疾病和病症的方法中的用途。